Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Marie G. Roger"'
Autor:
Sara Crespillo, Francisco Conejero-Lara, Pedro L. Mateo, Bertrand Morel, Salvador Casares, Raphaelle El-Habib, Nicolas Mouz, Frank Notka, Marie G. Roger, Fadia Manssour-Triedo
Publikováno v:
Biophysical journal. 111(4)
The HIV gp41 ectodomain (e-gp41) is an attractive target for the development of vaccines and drugs against HIV because of its crucial role in viral fusion to the host cell. However, because of the high insolubility of e-gp41, most biophysical and str
Autor:
Gilles Devillier, Lucia Lopalco, Mario Amacker, Daniela Tudor, L. Diomede, Qiang Wei, Gui Bo Yang, Rinaldo Zurbriggen, Sylvain Fleury, Yonatan Ganor, Nicolas Mouz, Zhe Cong, Anick Chalifour, Anne Sophie Drillet, Hong Gao, Marie G. Roger, Annette Alfsen, Chuan Qin, Morgane Bomsel
Publikováno v:
Immunity; Vol 34
SummaryHuman immunodeficiency virus (HIV)-1 is mainly transmitted mucosally during sexual intercourse. We therefore evaluated the protective efficacy of a vaccine active at mucosal sites. Macaca mulatta monkeys were immunized via both the intramuscul
Autor:
Ana Cámara-Artigas, Francisco Conejero-Lara, Bin Su, Bertrand Morel, Raphaelle El Habib, Marie G. Roger, Christophe Martin, Eva S. Cobos, Salvador Casares, Pedro L. Mateo, Nicolas Mouz, Christiane Moog, Sara Crespillo
Publikováno v:
'Proceedings of the National Academy of Sciences of the USA ', vol: 111, pages: 18207-18212 (2014)
During HIV-1 fusion to the host cell membrane, the N-terminal heptad repeat (NHR) and the C-terminal heptad repeat (CHR) of the envelope subunit gp41 become transiently exposed and accessible to fusion inhibitors or Abs. In this process, the NHR regi
Autor:
Christophe Martin, S Mourao, Alethea Cope, R El Habib, Robin J. Shattock, Nicolas Mouz, R Le Grand, Irene Luque, David J. M. Lewis, D Katinger, Christiane Moog, Karl Malcolm, Marie G. Roger, F Notka, Nathalie Bosquet, Francisco Conejero-Lara, Sara Crespillo, A. Farsang, Andreas Wagner
Publikováno v:
Retrovirology, Vol 9, Iss Suppl 2, p P354 (2012)
Retrovirology
Retrovirology
Background Gp41 of the HIV envelope, especially the MPER, contains highly conserved epitopes recognized by neutralizing monoclonal antibodies such as D5, 2F5 and 4E10. The correct presentation of the antigens is considered to be key for eliciting neu
Autor:
Marie G. Roger, Sylvain Fleury, Morgane Bomsel, Rinaldo Zurbriggen, A Drillet, Mario Amacker, Lucia Lopalco, Nicolas Mouz, G Devillers
Publikováno v:
Retrovirology, Vol 6, Iss Suppl 3, p P322 (2009)
Retrovirology
Retrovirology
Methods We have developed a mucosal vaccine candidate based on two complementary conserved gp41 subunit antigensa trimeric recombinant gp41 deleted in known immunodominant regions (rGp41) and the 35 amino acid peptide P1, this later adopting the 3D c