mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells

Autor: Abdullah Mayati, Amélie Moreau, Elodie Jouan, Marie Febvre-James, Claire Denizot, Yannick Parmentier, Olivier Fardel

Publikováno v: Pharmaceutics, Vol 10, Iss 4, p 246 (2018)

The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional expression of nucleoside transporters remains poorly characterized in HepaRG cells, although these t

Externí odkaz: https://doaj.org/article/a331245c50974f2b832089b411af91e9

The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes

Autor: Olivier Fardel, Marc Le Vee, Marie Febvre-James, Arnaud Bruyère

Publikováno v: Drug Metabolism and Disposition
Drug Metabolism and Disposition, 2018, 46 (2), pp.131-140. ⟨10.1124/dmd.117.078048⟩
Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2018, 46 (2), pp.131-140. ⟨10.1124/dmd.117.078048⟩

International audience; The inflammatory cytokine interleukin (IL)-6, which basically activates the Janus kinase (JAK)/ signal transducer and activator of transcription (STAT) signaling pathway, is well known to repress expression of hepatic cytochro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92863b4ccb41e11791bb7b9d7e2da95e
https://doi.org/10.1124/dmd.117.078048