Výsledky vyhledávání - "Marie E. Fraser"

Structural and functional insights into iron acquisition from lactoferrin and transferrin in Gram-negative bacterial pathogens

Autor: Clement Chan, Dixon Ng, Marie E. Fraser, Anthony B. Schryvers

Publikováno v: BioMetals. 36:683-702

Iron is an essential element for various lifeforms but is largely insoluble due to the oxygenation of Earth’s atmosphere and oceans during the Proterozoic era. Metazoans evolved iron transport glycoproteins, like transferrin (Tf) and lactoferrin (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bce991adf0bc9fb4ae0a860ef8ea38bd
https://doi.org/10.1007/s10534-022-00466-6

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The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase

Autor: Ji Huang, Marie E. Fraser

Publikováno v: Acta Crystallographica Section F Structural Biology Communications. 78:363-370

Succinyl-CoA synthetase (SCS) catalyzes a three-step reaction in the citric acid cycle with succinyl-phosphate proposed as a catalytic intermediate. However, there are no structural data to show the binding of succinyl-phosphate to SCS. Recently, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fc59604d3393e6b5b4f089f1fdbb05
https://doi.org/10.1107/s2053230x22008810

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Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase

Autor: Marie E. Fraser, Ji Huang

Publikováno v: Acta Crystallogr D Struct Biol

Succinyl-CoA synthetase (SCS) catalyzes a reversible reaction that is the only substrate-level phosphorylation in the citric acid cycle. One of the essential steps for the transfer of the phosphoryl group involves the movement of the phosphohistidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9e2aae7b9aabdcdf5f743ee11819c
https://doi.org/10.1107/s2059798321000334

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Tartryl-CoA inhibits succinyl-CoA synthetase

Autor: Ji Huang, Marie E. Fraser

Publikováno v: Acta Crystallogr F Struct Biol Commun

Succinyl-CoA synthetase (SCS) catalyzes the only substrate-level phosphorylation step in the tricarboxylic acid cycle. Human GTP-specific SCS (GTPSCS), an αβ-heterodimer, was produced inEscherichia coli. The purified protein crystallized from a sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d21ef50eea6ee1aece4864eecdb3c8
https://doi.org/10.1107/s2053230x20008201

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Akademický článek

Structural variation and uniformity among tetraloop-receptor interactions and other loop-helix interactions in RNA crystal structures.

Autor: Li Wu, Dinggeng Chai, Marie E Fraser, Steven Zimmerly

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49225 (2012)

Tetraloop-receptor interactions are prevalent structural units in RNAs, and include the GAAA/11-nt and GNRA-minor groove interactions. In this study, we have compiled a set of 78 nonredundant loop-helix interactions from X-ray crystal structures, and

Externí odkaz: https://doaj.org/article/16a9c9179b044fc6a30f1f85e5309429

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Binding of hydroxycitrate to human ATP-citrate lyase

Autor: Aruna Komakula, Marie E. Fraser, Jinhong Hu

Publikováno v: Acta Crystallographica Section D Structural Biology. 73:660-671

Hydroxycitrate from the fruit ofGarcinia cambogia[i.e.(2S,3S)-2-hydroxycitrate] is the best-known inhibitor of ATP-citrate lyase. Well diffracting crystals showing how the inhibitor binds to human ATP-citrate lyase were grown by modifying the protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33d375cdc25628218a3de4daa1310b5
https://doi.org/10.1107/s2059798317009871

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Identification of the active site residues in ATP-citrate lyase's carboxy-terminal portion

Autor: Vinh H Nguyen, Ana Medina, Marie E. Fraser, Isabel Usón, Noreen Singh

Publikováno v: Protein Sci
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ATP‐citrate lyase (ACLY) catalyzes production of acetyl‐CoA and oxaloacetate from CoA and citrate using ATP. In humans, this cytoplasmic enzyme connects energy metabolism from carbohydrates to the production of lipids. In certain bacteria, ACLY i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086b67bbbf873d6995338b5fdb6ae251
https://pubmed.ncbi.nlm.nih.gov/31411782

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ATP-specificity of succinyl-CoA synthetase from Blastocystis hominis

Autor: Ji Huang, Vinh H. Nguyen, Karleigh A. Hamblin, Robin Maytum, Mark van der Giezen, Marie E. Fraser

Publikováno v: Acta crystallographica. Section D, Structural biology. 75(Pt 7)

Succinyl-CoA synthetase (SCS) catalyzes the only step of the tricarboxylic acid cycle that leads to substrate-level phosphorylation. Some forms of SCS are specific for ADP/ATP or for GDP/GTP, while others can bind all of these nucleotides, generally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add7cc065602a0b4b628aa466ee8090e
https://pubmed.ncbi.nlm.nih.gov/31282474

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