Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration

Autor: Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Michel Paques, Torben Lykke Sørensen, Olaf Strauss, Xavier Guillonneau, Cécile Delarasse, Florian Sennlaub

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)

Abstract Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial cells but also of monocyte-deriv

Externí odkaz: https://doaj.org/article/15a2fe8398d24307833b4ae362a8cd9b

Tracking distinct microglia subpopulations with photoconvertible Dendra2 in vivo

Autor: Eric B. Miller, Sarah J. Karlen, Kaitryn E. Ronning, Marie E. Burns

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)

Key points New mouse for tracking microglia and all mononuclear phagocytes both ex and in vivo within the CNS over time. Dendra2 protein is stable enough to survive tissue processing for immunohistochemistry and flow cytometry quantification. Simulta

Externí odkaz: https://doaj.org/article/ba5ba7855c2848cb9a765f5ba2b37e0d

Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration

Autor: Sarah J. Karlen, Eric B. Miller, Xinlei Wang, Emily S. Levine, Robert J. Zawadzki, Marie E. Burns

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)

Abstract Background Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the central nervous syst

Externí odkaz: https://doaj.org/article/de2aceab721e4c049d0bad1d94745bd6

In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium

Autor: Sarah J. Karlen, Marie E. Burns, Kaitryn E. Ronning, Robert J. Zawadzki, Edward N. Pugh, Ratheesh Kumar Meleppat

Publikováno v: Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Melanosomes, lipofuscin, and melanolipofuscin are the three principal types of pigmented granules found in retinal pigment epithelium (RPE) cells. Changes in the density of melanosomes and lipofuscin in RPE cells are considered hallmarks of various r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147ce10f79aefc356b8bdb29ade6162
https://escholarship.org/uc/item/9qs636f5

In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury

Autor: Eric B. Miller, Pengfei Zhang, Edward N. Pugh, Marie E. Burns, Karli Ching

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 33
Proceedings of the National Academy of Sciences of the United States of America

Significance Microglia, the resident macrophages of the central nervous system, are critical for synaptic pruning and maintenance and for mitigating injury and neurodegeneration. Determining whether microglia–neuron interactions are beneficial in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4bec1e732cce01aacb86f2df1d7d3d
https://doi.org/10.1073/pnas.1903336116