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of 36
pro vyhledávání: '"Marie E. Beckner"'
Autor:
Marie E. Beckner
Publikováno v:
Cancer Research. 81:2319-2319
Potassium, the major intracellular cation, is released by neurons as they fire action potentials. Glial cells take up released K+ ions and later return them. Faulty glial K+ buffering contributes to seizures. Previously, in brain tumor patients treat
Autor:
Marie E. Beckner
Publikováno v:
Cancer Research. 80:3726-3726
Background: Glia in the CNS buffer potassium ions released by neurons as they fire action potentials. Glial activity occurs at synapses, along axons, and possibly throughout the glial network. Faulty glial potassium buffering can contribute to seizur
Autor:
Marie E. Beckner
Publikováno v:
Neurochemistry International. 136:104727
Glia use multiple mechanisms to mediate potassium fluxes that support neuronal function. In addition to changes in potassium levels within synapses, these ions are dynamically dispersed through the interstitial parenchyma, perivascular spaces, leptom
Autor:
Christian Weber, Marc A.M.J. Zandvoort, Rainer Hoffmann, Felix Vogt, Nicole Krott, Anja-Katrin Bosserhoff, Malte Kelm, Alma Zernecke, Marie E. Beckner, Thomas Jahnke, Rüdiger Blindt
Publikováno v:
Journal of the American College of Cardiology. 52:302-311
Objectives The aim of this study was to elucidate the role of angio-associated migratory cell protein (AAMP) for the migration of vascular smooth muscle cells (SMCs) and for the development of neointimal hyperplasia after vascular injury. Background
Autor:
Naomi R. Agostino, Esther P. Jane, Brian T. Jankowitz, Marie E. Beckner, Kevin A. Walter, Ronald L. Hamilton, Ian F. Pollack
Publikováno v:
Cancer Letters. 255:135-144
Studies of primary cells from malignant brain tumors such as glioblastomas are limited by the small size of surgically resected specimens. However, glioblastomas are also frequently debulked via ultrasonic aspiration. In this study, we examined the f
Publikováno v:
The FASEB Journal. 29
Relationships between amplified oncogenes and glycolysis were studied in glioblastomas (GBs) using ENO1 to define supraphysiologic metabolic gene expressions. Copy numbers (CN) of 78 oncogenes were...
Publikováno v:
Laboratory Investigation. 86:1103-1114
It is well accepted that dysfunction in the blood brain barrier (BBB) allows permeation of albumin from the bloodstream into astrocytic brain tumors, especially glioblastomas, the most aggressive astrocytomas. In vitro, bovine serum albumin (BSA) aid
Autor:
Fatima Burovic, Naomi R. Agostino, Roger Abounader, Glenn T. Gobbel, Ian F. Pollack, Marie E. Beckner, John Laterra
Publikováno v:
Laboratory Investigation. 85:1457-1470
Increased glycolysis is characteristic of malignancy. Previously, with a mitochondrial inhibitor, we demonstrated that glycolytic ATP production was sufficient to support migration of melanoma cells. Recently, we found that glycolytic enzymes were ab
Autor:
Ronald L. Hamilton, Eizaburo Sasatomi, Ian F. Pollack, Marie E. Beckner, Sydney D. Finkelstein, Patricia A. Swalsky
Publikováno v:
Human Pathology. 35:1105-1111
Hemangioblastomas (HBs) are low-grade (World Health Organization grade I/IV) central nervous system (CNS) tumors that frequently contain VHL (3p26) mutations. They occur sporadically and in von Hippel Lindau (VHL) disease. Encoded pVHL aids degradati
Publikováno v:
Surgical Neurology. 61:274-277
Background Giant cell tumors are benign lesions that typically occur at the epiphyses of long bones that typically present with pain or swelling. Most data on giant cell tumors in the skull consist of case reports, and many large series of giant cell