Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Marie Dominique Filippi"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Hematopoietic stem cells (HSCs) have the properties to self-renew and/or differentiate into any blood cell lineages. In order to balance the maintenance of the stem cell pool with supporting mature blood cell production, the fate decisions to self-re
Externí odkaz:
https://doaj.org/article/1e1bf575f4de4eeabd6e850300928b27
Autor:
Waseem Nasr, Marie-Dominique Filippi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The disorders known as bone marrow failure syndromes (BMFS) are life-threatening disorders characterized by absence of one or more hematopoietic lineages in the peripheral blood. Myelodysplastic syndromes (MDS) are now considered BMF disorders with a
Externí odkaz:
https://doaj.org/article/6dde32942e554c40acf0fdbe3c527a6f
Autor:
Chanchal Sur Chowdhury, Elizabeth Wareham, Juying Xu, Sachin Kumar, Matthew Kofron, Sribalaji Lakshmikanthan, Magdalena Chrzanowska, Marie-Dominique Filippi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionNeutrophils are critical for host immune defense; yet, aberrant neutrophil tissue infiltration triggers tissue damage. Neutrophils are heterogeneous functionally, and adopt ‘normal’ or ‘pathogenic’ effector function responses. Und
Externí odkaz:
https://doaj.org/article/c534e99458ed422c9ee9dbae3177c31c
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Bone marrow failure syndromes are characterized by ineffective hematopoiesis due to impaired fitness of hematopoietic stem cells. They can be acquired during bone marrow stress or innate and are associated with driver genetic mutations. Patients with
Externí odkaz:
https://doaj.org/article/014ec646c013428286b42f4c37ca2278
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil granulocytes represent the first line of defense against invading pathogens. In addition to the production of Reactive Oxygen Species, degranulation, and phagocytosis, these specialized cells are able to extrude Neutrophil Extracellular Tr
Externí odkaz:
https://doaj.org/article/a39f35a2147e42da8d8dba328e0c0c12
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Neutrophil granulocytes are key components of the innate immune system. As the first responders to inflammatory cues, they rapidly migrate toward the site of infection or inflammation and fulfill diverse effector functions. Since these effector funct
Externí odkaz:
https://doaj.org/article/bb97a0484bc44dac8632e9a885c8d444
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
Autor:
Ping Hu, Angel R. Nebreda, Helmut Hanenberg, Garrett H. Kinnebrew, Mircea Ivan, Mervin C. Yoder, Marie-Dominique Filippi, Hal E. Broxmeyer, Reuben Kapur
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and th
Externí odkaz:
https://doaj.org/article/83c7d281d7c544558201dc263cf809c2
Autor:
Ashwini Hinge, Juying Xu, Jose Javier, Eucabeth Mose, Sachin Kumar, Reuben Kapur, Edward F. Srour, Punam Malik, Bruce J. Aronow, Marie-Dominique Filippi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances s
Externí odkaz:
https://doaj.org/article/aa4e1e51138e4312ba30120be3566b6b
Autor:
Lindsey-Romick Rosendale, Marie Dominique Filippi, Miki Watanabe-Chailland, Serena Liu, Kenjiro Shima, Brenna Carey, Rajesh K Kasam, Paritha Arumugam, M. Wessendarp, Claudia Chalk, Traci E. Stankiewicz, Y. Ma
Publikováno v:
Mitochondrion
Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on macrophages and is required for self-renewal but the mechanisms responsible are unknown. Using mouse models with disrupted GM-CSF signaling, we show GM-CSF is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d330846ded0cf079c33baed828cc90
https://doi.org/10.1016/j.mito.2021.10.009
https://doi.org/10.1016/j.mito.2021.10.009
Autor:
Ashley E. Culver-Cochran, Marie-Dominique Filippi, Joshua R. Bennett, Kathleen Hueneman, Emily Stepanchick, James Bartram, Mark Wunderlich, John P. Perentesis, Daniel T. Starczynowski, Timothy M. Chlon, Lyndsey Bolanos, Madeline Niederkorn, Emma Uible, Kwangmin Choi, Chiharu Ishikawa
Publikováno v:
Leukemia
Ubiquitin-specific peptidase 15 (USP15) is a deubiquitinating enzyme implicated in critical cellular and oncogenic processes. We report that USP15 mRNA and protein are overexpressed in human acute myeloid leukemia (AML) as compared to normal hematopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e7d2bb59628468f7859a7a88e84f6d
https://doi.org/10.1038/s41375-021-01394-z
https://doi.org/10.1038/s41375-021-01394-z