Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marie Daval"'
Publikováno v:
Diabetes, vol 60, iss 4
Diabetes
Diabetes
OBJECTIVE Cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 has recently been linked to type 2 diabetes by genome-wide association studies. While CDK5 and its regulatory protein p35 are both expressed and display enzymat
Autor:
Chang Jiang Huang, Aleksey V. Matveyenko, Tatyana Gurlo, Marie Daval, Safia Costes, Peter C. Butler, Alexandra E. Butler, Robert A. Rizza
Publikováno v:
Diabetes
Diabetes, vol 60, iss 1
Diabetes, vol 60, iss 1
OBJECTIVE The islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP). Toxic oligomers of IAPP form intracellularly in β-cells in
Publikováno v:
Diabetes
OBJECTIVE Obesity is a known risk factor for type 2 diabetes. However, most obese individuals do not develop diabetes because they adapt to insulin resistance by increasing β-cell mass and insulin secretion. Islet pathology in type 2 diabetes is cha
Publikováno v:
The Journal of Physiology. 574:55-62
AMP-activated protein kinase (AMPK) is involved in cellular energy homeostasis. Its functions have been extensively studied in muscles and liver. AMPK stimulates pathways which increase energy production (glucose transport, fatty acid oxidation) and
Publikováno v:
Journal de la Société de Biologie. 200:99-105
Le maintien de la balance energetique est un processus fondamental pour l'organisme. Un desequilibre entre les apports et la depense energetique peut avoir de graves consequences, comme en temoigne aujourd'hui l'augmentation de la prevalence de l'obe
Autor:
Sahar Bedrood, Peter C. Butler, Ralf Langen, Marie Daval, Tatyana Gurlo, Chang-jiang Huang, Safia Costes
Publikováno v:
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 17(3-4)
Type 2 diabetes involves aberrant misfolding of human islet amyloid polypeptide (h-IAPP) and resultant pancreatic amyloid deposits. Curcumin, a biphenolic small molecule, has offered potential benefits in other protein misfolding diseases, such as Al
Autor:
Chang-jiang Huang, Jacqueline F. Rivera, Safia Costes, Tatyana Gurlo, Peter C. Butler, Marie Daval, Aleksey V. Matveyenko
In type II diabetes (T2DM), there is a deficit in β-cells, increased β-cell apoptosis and formation of intracellular membrane-permeant oligomers of islet amyloid polypeptide (IAPP). Human-IAPP (h-IAPP) is an amyloidogenic protein co-expressed with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf882114ac41619c4eb371e2698b96b
https://europepmc.org/articles/PMC3132000/
https://europepmc.org/articles/PMC3132000/
Autor:
Jean François Gautier, J. M. Servant, Fabienne Foufelle, Isabelle Hainault, Olivier Bourron, Pascal Ferré, Marie Daval, Eric Hajduch
Publikováno v:
Diabetologia
Diabetologia, 2010, 53 (4), pp.768-778. ⟨10.1007/s00125-009-1639-6⟩
Diabetologia, Springer Verlag, 2010, 53 (4), pp.768-778. ⟨10.1007/s00125-009-1639-6⟩
Diabetologia, 2010, 53 (4), pp.768-778. ⟨10.1007/s00125-009-1639-6⟩
Diabetologia, Springer Verlag, 2010, 53 (4), pp.768-778. ⟨10.1007/s00125-009-1639-6⟩
In rodent adipocytes, activated AMP-activated protein kinase reduces the lipolytic rate. As the hypoglycaemic drugs metformin and thiazolidinediones activate this enzyme in rodents, we tested the hypothesis that in addition to their known actions the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f506009ca00c12d546497a44ea132c
https://hal.science/hal-02450943
https://hal.science/hal-02450943
Autor:
Tatyana Gurlo, Sergey Ryazantsev, Chang-jiang Huang, Marie Daval, Xiuji Wu, Safia Costes, Peter C. Butler, Alexandra E. Butler, Leena Haataja
Publikováno v:
The Journal of biological chemistry. 285(1)
The islet in type 2 diabetes (T2DM) and the brain in neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (IAPP) in T2DM). Excessiv
Publikováno v:
Journal de la Societe de biologie. 200(1)
Impairment in the regulation of energy homeostasis and imbalance between energy intake and energy expenditure lead to many metabolic disorders and diseases such as obesity and type 2 diabetes. AMP-activated protein kinase (AMPK) is considered as a "f