Výsledky vyhledávání - "Marie Croisier"

Akademický článek

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

Autor: Nathan Riguet, Anne-Laure Mahul-Mellier, Niran Maharjan, Johannes Burtscher, Marie Croisier, Graham Knott, Janna Hastings, Alice Patin, Veronika Reiterer, Hesso Farhan, Sergey Nasarov, Hilal A. Lashuel

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-27 (2021)

The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal

Externí odkaz: https://doaj.org/article/81663cd6def2472ea737c63e01d4fdd8

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Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics

Autor: Sofia Zaganelli, Evangelia Vartholomaiou, Emilie Cuillery, Jean-Claude Martinou, Suliana Manley, Marie Croisier, Timo Rey

Publikováno v: Nature cell biology
Nature Cell Biology

Phase separation concentrates mitochondrial RNA granules. Here Rey et al., show that mitochondrial RNA granules (MRGs) behaviour is consistent with liquid-liquid phase separation (LLPS) and their fusion coincides with mitochondrial remodelling. Mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0857708b259a09443ffb6f355617b9
https://doi.org/10.1038/s41556-020-00584-8

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The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Autor: Anne-Laure Mahul-Mellier, Niran Maharjan, Marie Croisier, Laura Weerens, Johannes Burtscher, Marion Leleu, Graham Knott, Fabien Kuttler, Hilal A. Lashuel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Although converging evidence point to α-synuclein aggregation and Lewy body (LB) formation as central events in Parkinson’s disease, the molecular mechanisms that regulate these processes and their role in disease pathogenesis remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa574e43210856d0b0e48f4334ed57de
https://doi.org/10.1073/pnas.1913904117

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Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

Autor: Hesso Farhan, Nathan Riguet, Graham Knott, Alice Patin, Veronika Reiterer, Niran Maharjan, Anne-Laure Mahul-Mellier, Sergey Nasarov, Janna Hastings, Marie Croisier, Hilal A. Lashuel, Johannes Burtscher

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-27 (2021)
Nature Communications

Despite the strong evidence linking the aggregation of the Huntingtin protein (Htt) to the pathogenesis of Huntington’s disease (HD), the mechanisms underlying Htt aggregation and neurodegeneration remain poorly understood. Herein, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beb61f696ae4c4981d1f362b39dd69f
https://doi.org/10.1101/2020.07.29.226977

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The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathies

Autor: Johannes Burtscher, Graham Knott, Weerens L, Hilal A. Lashuel, Mahul-Mellier A, Marion Leleu, Fabien Kuttler, Maharjan N, Marie Croisier

Parkinson’s disease (PD) is characterized by the accumulation of misfolded alpha-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LB). Although it is widely believed that α-syn plays a central role in the pathogenesis of PD and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f04d4263c179c25bbe27627b4d1285

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The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions

Although converging evidence point to alpha-synuclein (a-syn) aggregation and Lewy body (LB) formation as central events in Parkinson's disease (PD), the molecular mechanisms that regulate these processes and their role in disease pathogenesis remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4517976da85ea71889fb8ca1c00979c9
https://doi.org/10.1101/500058

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NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

Autor: Marie Croisier, Graham Knott, Anders Meibom, Curt A. Davey, Kai Johnsson, Ronald F. S. Lee, Stéphane Escrig, Paul J. Dyson, Stéphanie Clerc-Rosset

Publikováno v: Chemical communications (Cambridge, England). 51(92)

The in vitro inter- and intra-cellular distribution of an isotopically labelled ruthenium(II)-arene (RAPTA) anti-metastatic compound in human ovarian cancer cells was imaged using nano-scale secondary ion mass spectrometry (NanoSIMS). Ultra-high reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3725d23a2cc74f3eae4b0cff51864d31
https://pubmed.ncbi.nlm.nih.gov/26507472

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Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(ii) drug to probe its distribution and state in vitro

Autor: Stéphanie Clerc-Rosset, Curt A. Davey, Graham Knott, Marie Croisier, Paul J. Dyson, Stéphane Escrig, Ronald F. S. Lee, Kai Johnsson, Anders Meibom

Publikováno v: Chemical Communications. 51:16577-16577

Correction for ‘NanoSIMS analysis of an isotopically labelled organometallic ruthenium(ii) drug to probe its distribution and state in vitro’ by Ronald F. S. Lee et al., Chem. Commun., 2015, DOI: 10.1039/c5cc06983a.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::589de229932841a53a72f04c3822be88
https://doi.org/10.1039/c5cc90487k

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