Delayed Cardiomyopathy in Dystrophin Deficient mdx Mice Relies on Intrinsic Glutathione Resource

Autor: Marie-Claude Bourin, Magali Perier, Christophe Meune, Françoise Pecker, Karim Wahbi, Catherine Pavoine, Lara Khouzami, Thibaud Damy, Christo Christov, Brigitte Escoubet, Philippe Caramelle

Publikováno v: The American Journal of Pathology. 177:1356-1364

Oxidative stress contributes to the pathogenesis of Duchenne muscular dystrophy (DMD). Although they have been a model for DMD, mdx mice exhibit slowly developing cardiomyopathy. We hypothesized that disease process was delayed owing to the developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e46b12f1664f53559c1947f100e7252
https://doi.org/10.2353/ajpath.2010.090479

Decreased type VI adenylyl cyclase mRNA concentration and Mg2+-dependent adenylyl cyclase activities and unchanged type V adenylyl cyclase mRNA concentration and Mn2+-dependent adenylyl cyclase activities in the left ventricle of rats with myocardial infarction and longstanding heart failure

Autor: Jean-Jacques Mercadier, Isabelle Espinasse, Jean-Baptiste Michel, Jean-François Giudicelli, Christine Richer, Françoise Samson, Michèle Heimburger, Marie-Claude Bourin, Nicole Defer, Jacques Hanoune, Vadim Iourgenko, Eric Pussard

Publikováno v: Cardiovascular Research. 42:87-98

Objective: To address the effect of longstanding left ventricular (LV) hypertrophy and failure on LV adenylyl cyclase (AC) gene expression, mRNA concentrations of the main cardiac AC isoforms were measured in the non-infarcted area of LV from rats wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abe3ad0f581ab3e91987e981172c54e
https://doi.org/10.1016/s0008-6363(98)00283-1

The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts

Autor: Xavier Norel, Dan Longrois, Laurent Boyer, Pierre Validire, Sophie Hue, Jean-Luc Dubois-Randé, Sandra Chrusciel, Jorge Boczkowski, Corinne Duprez, Jean-Marie Gagliolo, Marie-Claude Bourin, Philippe Caramelle, Sabine Le Gouvello, Maylis Dagouassat, Serge Adnot, Jean-Baptiste Stern

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2013, 187 (7), pp.703-714. ⟨10.1164/rccm.201208-1361OC⟩

International audience; Rationale: Chronic obstructive pulmonary disease (COPD) is associated with lung fibroblast senescence, a process characterized by the irreversible loss of replicative capacity associated with the secretion of inflammatory medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801e00d397819195f49406d28196e60b
https://pubmed.ncbi.nlm.nih.gov/23328527

Mesoglycan and Sulodexide Act as Stabilizers and Protectors of Fibroblast Growth Factors (FGFs)

Autor: Denis Barritault, Pascal Barbier, Pascal Desgranges, Michele Tardieu, Marie-Claude Bourin, Jean-Pierre Caruelle

Publikováno v: Growth Factors. 11:291-300

Heparin and heparan sulfate proteoglycans (HSPGs) stabilize FGFs which belong to heparin-binding growth factors (HBGFs) on active conformation. They also strongly potentiate their mitogenic activity on many cell types, and protect them against therma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4181c34e2da65afddbff719e131721
https://doi.org/10.3109/08977199409011002

The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy

Autor: Andreas Zimmer, Brigitte Escoubet, Françoise Pecker, Jinghong Wan, Nicole Defer, Catherine Pavoine, Richard Souktani, Marie-Claude Bourin, Sophie Lotersztajn, Magali Perier, Vanessa Deveaux, Sylvie Manin, Philippe Caramelle

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(7)

Post-myocardial infarction (MI) heart failure is a major public health problem in Western countries and results from ischemia/reperfusion (IR)-induced cell death, remodeling, and contractile dysfunction. Ex vivo studies have demonstrated the cardiopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161f334729bbe2c8a5b1fed19dcc1563
https://pubmed.ncbi.nlm.nih.gov/19246487