Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Marie Charbaut"'
Autor:
Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:28-33
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03145f782eb525e093f927857c7919cd
https://doi.org/10.1016/j.bmcl.2007.11.019
https://doi.org/10.1016/j.bmcl.2007.11.019
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs
Autor:
N. Paul King, Stefan Senger, Matthew Campbell, Henry Anderson Kelly, Máire A. Convery, David W. Brown, Shah Gita Punjabhai, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Marie Charbaut, Alan D. Borthwick, Ivan Leo Pinto, Weston Helen Elisabeth, John R. Toomey, Chuen Chan, Chun-wa Chung, Robert J. Young, Nigel S. Watson, Derek Pollard, Andrew M. Mason, Anthony J. Pateman
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(1)
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15050912d1dc4249e4e1cc6903a7abeb
https://pubmed.ncbi.nlm.nih.gov/18054228
https://pubmed.ncbi.nlm.nih.gov/18054228