Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Autor: Ellis Chika Onwordi, Els F. Halff, Thomas Whitehurst, Ayla Mansur, Marie-Caroline Cotel, Lisa Wells, Hannah Creeney, David Bonsall, Maria Rogdaki, Ekaterina Shatalina, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Sridhar Natesan, Anthony C. Vernon, Oliver D. Howes

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected

Externí odkaz: https://doaj.org/article/d2e6a5e593d0405db0ad2d55f3b35447

Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex

Autor: Els F. Halff, R McQuade, Marie Caroline Cotel, Deepak P Srivastiva, Oliver D. Howes, Anthony C. Vernon, Sridhar Natesan, Chris J. Ottley

The pathophysiology of the majority of neuropsychiatric disorders, including schizophrenia and mood disorders, involves synaptic dysfunction and/or loss, manifesting as lower levels of several presynaptic and postsynaptic marker proteins. Whether chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5da0f5ae3890baf0004407ef81e354b

Effects of chronic antipsychotic drug exposure on the expression of Translocator Protein and inflammatory markers in rat adipose tissue

Autor: Anthony C. Vernon, Valeria Mondelli, Sridhar Natesan, Marie-Caroline Cotel, Mike Modo, Anita Calevro

Publikováno v: Calevro, A, Cotel, M-C, Natesan, S, Modo, M, Vernon, A C & Mondelli, V 2018, ' Effects of chronic antipsychotic drug exposure on the expression of Translocator Protein and inflammatory markers in rat adipose tissue ', Psychoneuroendocrinology . https://doi.org/10.1016/j.psyneuen.2018.05.021

The precise effect of antipsychotic drugs on either central or peripheral inflammation remains unclear. An important issue in this debate is to what extent the known peripheral metabolic effects of antipsychotics, including increased adiposity, may c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ea7aa433616f49b4e091d3db7d105f
https://doi.org/10.1016/j.psyneuen.2018.05.021

O11.3. SYNAPTIC MARKER PROTEIN SV2A IS REDUCED IN SCHIZOPHRENIA IN VIVO AND UNAFFECTED BY ANTIPSYCHOTICS IN RATS

Autor: Lisa Wells, Hannah Creeney, Oliver D. Howes, Sridhar Natesan, Maria Rogdaki, Thomas Whitehurst, Ekaterina Shatalina, Tiago Reis Marques, Anthony C. Vernon, Ellis Chika Onwordi, Els F. Halff, Ayla Mansur, Marie-Caroline Cotel, David R. Bonsall, Roger N. Gunn, Eugenii A. Rabiner

Publikováno v: Schizophrenia Bulletin

Background The synaptic dysfunction hypothesis of schizophrenia is supported by multiple lines of evidence. However, in vivo evidence is lacking. Moreover, it is not known if antipsychotics alter synaptic protein levels. We addressed this in a combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146c641727ad9c1ee976a80f09c41bb3
https://doi.org/10.1093/schbul/sbaa028.063

Psychiatric risk geneNT5C2regulates protein translation in human neural progenitor cells

Autor: Sang Hyuck Lee, Robin M. Murray, Marie-Caroline Cotel, Ioannis Eleftherianos, Nicholas John Bray, Rodrigo R.R. Duarte, Deepak Srivastava, Gerome Breen, Nathaniel D. Bachtel, Gary A. Hovsepian, Douglas F. Nixon, Claire Troakes, Anthony C. Vernon, Timothy R. Powell, Iain A. Watson, Sashika Selvackadunco

Genome-wide significant variants associated with combined risk for major psychiatric disorders on chromosome 10q24 affect the expression of the cytosolic 5’-nucleotidase II (NT5C2, cN-II) in population controls, implicating it as a psychiatric susc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e843cbe3fd579d0376ba75054c8e1dd4
https://doi.org/10.1101/468546