A case study of the MAC (masked acyl cyanide) oxyhomologation of N,N-dibenzyl-l-phenylalaninal with anti diastereoselectivity: preparation of (2S,3S)-allophenylnorstatin esters

Autor: Xuefeng He, Marie Buchotte, Régis Guillot, Sandrine Deloisy, David J. Aitken

Publikováno v: Organic & Biomolecular Chemistry. 20:1769-1781

The three-component reaction proceeds with unhindered alcohols in good yield and high anti diastereoselectivity to give protected ester derivatives of (2S,3S)-allophenylnorstatin and provides an expedient access to the amino acid itself.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8980e21b7c7fddbee7e8d4c0a5f51c90
https://doi.org/10.1039/d1ob02411f

Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate

Autor: Vivien Herrscher, Clea Witjaksono, Marie Buchotte, Claire Ferret, Fabien Massicot, Jean‐Luc Vasse, Franck Borel, Jean‐Bernard Behr, Myriam Seemann

Publikováno v: Chemistry – A European Journal. 28

IspG (also called GcpE) is an oxygen-sensitive [4Fe-4S] enzyme catalyzing the penultimate step of the methylerythritol phosphate (MEP) pathway, a validated target for drug development. It converts 2-C-methyl-d-erythritol-2,4-cyclo-diphosphate (MEcPP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b69fde953aaa631bc96201ee2e149
https://doi.org/10.1002/chem.202200241

Reversal of Diastereoselectivity in a Masked Acyl Cyanide (MAC) Reaction: Synthesis of Protected erythro-β-Hydroxyaspartate Derivatives

Autor: Marie Buchotte, Sandrine Deloisy, David J. Aitken, Mathieu Esgulian, Régis Guillot

Publikováno v: Organic Letters. 21:2378-2382

Using Garner's aldehyde as a substrate, one-pot MAC hydroxyhomologation reactions proceeded in good yields and with anti selectivity for the first time (dr up to 9:1). The products were used to prepare a panel of protected derivatives of erythro-β-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1063e7bd79e84df6f873ca18dc14a10
https://doi.org/10.1021/acs.orglett.9b00664

Study of the conformational behaviour of trehalose mycolates by FT-IR spectroscopy

Autor: Jean-Marie Beau, Nicolas Bayan, Federica Migliardo, Marie Buchotte, Yann Bourdreux, Gilles Doisneau

Publikováno v: Chemistry and Physics of Lipids
Chemistry and Physics of Lipids, Elsevier, 2019, pp.104789. ⟨10.1016/j.chemphyslip.2019.104789⟩
Chemistry and Physics of Lipids, 2019, pp.104789. ⟨10.1016/j.chemphyslip.2019.104789⟩

Mycolic acids are fundamental cell wall components, found in the outer membrane barrier (mycomembrane) of Mycobacterium related genera, that have shown antigenic, murine innate immunity inducting and inflammatory activity triggering action. The mycol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bff9705ebf33cca57ad83cd92cc4aa0
https://pubmed.ncbi.nlm.nih.gov/31254497

Optimization of microwave plasma treatment conditions on polydimethylsiloxane films for further surface functionalization

Autor: Hanène Salmi-Mani, Diana Dragoe, Caroline Aymes-Chodur, Nadine Aubry-Barroca, Marie Buchotte, Philippe Roger

Publikováno v: European Polymer Journal. 150:110416

Polydimethylsiloxane (PDMS) was surface functionalized by a 3-steps process. Firstly, the PDMS surface was activated by means of a microwave Ar/O2 plasma treatment, that was optimized in this paper. Secondly, the activated surface reacted with mercap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc08f786124b8ed9d9e8fce19874f8d4
https://doi.org/10.1016/j.eurpolymj.2021.110416