Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marie Boutant"'
Autor:
Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, José L. Sanchez-Garcia, Maria P. Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S. Kulkarni, Sofia Moco, Carles Canto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts. Here the authors provide insight into th
Externí odkaz:
https://doaj.org/article/d868646ab078447ea44fb258c12312d5
Autor:
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide
Externí odkaz:
https://doaj.org/article/bed4a8bce0a947e6b296d8080b0074aa
Autor:
Marie Boutant, Sameer S. Kulkarni, Magali Joffraud, Frédéric Raymond, Sylviane Métairon, Patrick Descombes, Carles Cantó
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2068-2075 (2016)
Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD+-dependent deacetylase enzyme, has been suggested to mediate the adaptive responses
Externí odkaz:
https://doaj.org/article/646dca569ff44c9b95ebcbfa75c3fae7
Autor:
Marie Boutant, Oscar Henrique Pereira Ramos, Cécile Tourrel-Cuzin, Jamileh Movassat, Anissa Ilias, David Vallois, Julien Planchais, Jean-Paul Pégorier, Frans Schuit, Patrice X Petit, Pascale Bossard, Kathrin Maedler, Anne Grapin-Botton, Mireille Vasseur-Cognet
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30847 (2012)
BackgroundThe control of the functional pancreatic β-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the normal range. It is not fully understood though how β-cell mass is determined.Met
Externí odkaz:
https://doaj.org/article/1f6708c21d4c4516b38f716804624284
Autor:
Marie Boutant, Oscar Henrique Pereira Ramos, Cécile Lecoeur, Emmanuel Vaillant, Julien Philippe, Pili Zhang, Anaïs Perilhou, Beatriz Valcarcel, Sylvain Sebert, Mario-Ritta Jarvelin, Beverley Balkau, Donald Scott, Philippe Froguel, Martine Vaxillaire, Mireille Vasseur-Cognet
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35810 (2012)
The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory re
Externí odkaz:
https://doaj.org/article/bdc908c6a0ef46f38c8b8cd7b37a064f
Autor:
Carles Cantó, Angelique Cercillieux, Joanna Ratajczak, Armand Valsesia, Judith Giroud-Gerbetant, Jose L. Sanchez-Garcia, Sofia Moco, Magali Joffraud, Miriam Valera-Alberni, Sameer S. Kulkarni, Marie Boutant, Maria Pilar Giner, Audrey Sambeat
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Supplementation with the NAD+ precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously
Autor:
Antonio Zorzano, Joanna Ratajczak, Carles Cantó, Riekelt H. Houtkooper, Sameer S. Kulkarni, Sylviane Metairon, Patrick Descombes, María Isabel Hernández-Alvarez, Magali Joffraud, Catherine Maclachlan, Arwen W. Gao, Frederic Raymond, Marie Boutant
Publikováno v:
Diabetes, 65(12), 3552-3560. American Diabetes Association Inc.
Mitochondrial function can be influenced by mitochondrial shape and connectivity with other cellular organelles through fusion and fission processes. Disturbances in mitochondrial architecture and mitochondrial fusion-related genes are observed in si
Autor:
Frederic Raymond, Carles Cantó, Marie Boutant, Sameer S. Kulkarni, Magali Joffraud, Sylviane Metairon, Patrick Descombes
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2068-2075 (2016)
SummaryCaloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD+-dependent deacetylase enzyme, has been suggested to mediate the adaptive re
Autor:
Cyril Besson, Carles Cantó, Elvis A. Carnero, Nicholas T. Broskey, Chiara Greggio, Sylviane Lagarrigue, Sonia Conde Alonso, Francesca Amati, Yoan Arribat, Marie Boutant, Sameer S. Kulkarni
Publikováno v:
Acta physiologica, vol. 225, no. 2, pp. e13179
Healthy ageing interventions encompass regular exercise to prevent mitochondrial dysfunction, key player in sarcopenia pathogenesis. Mitochondrial biogenesis has been well documented, but mitochondrial remodelling in response to exercise training is
Autor:
Francesca Amati, Carles Cantó, Leopold Schlueter, Didier Hans, Andreas Boss, Chris Boesch, Roland Kreis, Gérald Gremion, Nicholas T. Broskey, Chiara Greggio, Andrew A. Dwyer, Marie Boutant
Publikováno v:
Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 5, pp. 1852-1861
The Journal of clinical endocrinology and metabolism
Broskey, Nicholas T.; Greggio, Chiara; Boss, Andreas; Boutant, Marie; Dwyer, Andrew; Schlueter, Leopold; Hans, Didier; Gremion, Gerald; Kreis, Roland; Boesch, Chris; Canto, Carles; Amati, Francesca (2014). Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. The Journal of clinical endocrinology and metabolism, 99(5), pp. 1852-1861. The Endocrine Society 10.1210/jc.2013-3983
The Journal of clinical endocrinology and metabolism
Broskey, Nicholas T.; Greggio, Chiara; Boss, Andreas; Boutant, Marie; Dwyer, Andrew; Schlueter, Leopold; Hans, Didier; Gremion, Gerald; Kreis, Roland; Boesch, Chris; Canto, Carles; Amati, Francesca (2014). Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. The Journal of clinical endocrinology and metabolism, 99(5), pp. 1852-1861. The Endocrine Society 10.1210/jc.2013-3983
CONTEXT: Sarcopenia is thought to be associated with mitochondrial (Mito) loss. It is unclear whether the decrease in Mito content is consequent to aging per se or to decreased physical activity. OBJECTIVES: The objective of the study was to examine