Výsledky vyhledávání - "Marie Björnholm"

Akademický článek

Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

Autor: Wataru Aoi, Ryo Inoue, Katsura Mizushima, Akira Honda, Marie Björnholm, Tomohisa Takagi, Yuji Naito

Publikováno v: iScience, Vol 26, Iss 3, Pp 106251- (2023)

Summary: Habitual exercise alters the intestinal microbiota composition, which may mediate its systemic benefits. We examined whether transplanting fecal microbiota from trained mice improved skeletal muscle metabolism in high-fat diet (HFD)-fed mice

Externí odkaz: https://doaj.org/article/046ce76fdfa9477893f7bc2fd28db891

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Akademický článek

Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet

Autor: Emmani B.M. Nascimento, Louise Mannerås-Holm, Alexander V. Chibalin, Marie Björnholm, Juleen R. Zierath

Publikováno v: Journal of Lipid Research, Vol 59, Iss 2, Pp 273-282 (2018)

Conversion of diacylglycerol to phosphatidic acid is mediated by diacylglycerol kinases (DGKs), with DGKα specifically linked to adaptive immune responses. We determined the role of DGKα in obesity and inflammatory responses to a high-fat diet (HFD

Externí odkaz: https://doaj.org/article/af6160f27775468b9fc3787c521c2c23

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Akademický článek

DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism

Autor: Boubacar Benziane, Melissa L. Borg, Robby Z. Tom, Isabelle Riedl, Julie Massart, Marie Björnholm, Marc Gilbert, Alexander V. Chibalin, Juleen R. Zierath

Publikováno v: Journal of Lipid Research, Vol 58, Iss 12, Pp 2324-2333 (2017)

Diacylglycerol kinases (DGKs) regulate the balance between diacylglycerol (DAG) and phosphatidic acid. DGKζ is highly abundant in skeletal muscle and induces fiber hypertrophy. We hypothesized that DGKζ influences functional and metabolic adaptatio

Externí odkaz: https://doaj.org/article/a575ec213d4c468c8904d8f011c9405b

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Akademický článek

Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice[S]

Autor: Louise Mannerås-Holm, Milena Schönke, Joseph T. Brozinick, Laurène Vetterli, Hai-Hoang Bui, Philip Sanders, Emmani B.M. Nascimento, Marie Björnholm, Alexander V. Chibalin, Juleen R. Zierath

Publikováno v: Journal of Lipid Research, Vol 58, Iss 5, Pp 907-915 (2017)

Diacylglycerol kinases (DGKs) catalyze the phosphorylation and conversion of diacylglycerol (DAG) into phosphatidic acid. DGK isozymes have unique primary structures, expression patterns, subcellular localizations, regulatory mechanisms, and DAG pref

Externí odkaz: https://doaj.org/article/2bf3b5d7e0a349b4bf872fc42ccb5f83

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Akademický článek

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

Autor: Jorge C. Correia, Julie Massart, Jan Freark de Boer, Margareta Porsmyr-Palmertz, Vicente Martínez-Redondo, Leandro Z. Agudelo, Indranil Sinha, David Meierhofer, Vera Ribeiro, Marie Björnholm, Sascha Sauer, Karin Dahlman-Wright, Juleen R. Zierath, Albert K. Groen, Jorge L. Ruas

Publikováno v: Molecular Metabolism, Vol 4, Iss 12, Pp 891-902 (2015)

Objective: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. Methods: We expressed ea

Externí odkaz: https://doaj.org/article/8ebda816bd19486b9e767bdbd21f6a38

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Akademický článek

Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

Autor: Tingqing Guo, Patricia Marmol, Annalena Moliner, Marie Björnholm, Chao Zhang, Kevan M Shokat, Carlos F Ibanez

Publikováno v: eLife, Vol 3 (2014)

Obesity is associated with blunted β-adrenoreceptor (β-AR)-mediated lipolysis and lipid oxidation in adipose tissue, but the mechanisms linking nutrient overload to catecholamine resistance are poorly understood. We report that targeted disruption

Externí odkaz: https://doaj.org/article/909ce91d0b794f94bf6e2419ec4a5b1a

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Akademický článek

TXNIP regulates peripheral glucose metabolism in humans.

Publikováno v: PLoS Medicine, Vol 4, Iss 5, p e158 (2007)

BackgroundType 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mecha

Externí odkaz: https://doaj.org/article/98dbd792b47649e2b7e84b11f8d7654b

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Discovery of thymosin β4 as a human exerkine and growth factor

Autor: Marie Björnholm, Jonas T. Treebak, Atul S. Deshmukh, Niklas Rye Jørgensen, Christoffer Clemmensen, Anna Krook, Alba Gonzalez-Franquesa, Juleen R. Zierath, Emilie Dalbram, Håkan Karlsson, Stanislava Pankratova, Ben Stocks, Morten Hostrup, Sevda Gheibi, Alexander V. Chibalin, Ankita Agrawal, Thomas Nielsen, Melissa L. Borg, Michael S. Kuefner

Publikováno v: Gonzalez-Franquesa, A, Stocks, B, Borg, M L, Kuefner, M, Dalbram, E, Nielsen, T S, Agrawal, A, Pankratova, S, Chibalin, A V, Karlsson, H K R, Gheibi, S, Björnholm, M, Jørgensen, N R, Clemmensen, C, Treebak, J T, Hostrup, M, Krook, A, Zierath, J R & Deshmukh, A S 2021, ' Discovery of thymosin β4 as a human exerkine and growth factor ', American Journal of Physiology: Cell Physiology, vol. 321, no. 5, pp. C770-C778 . https://doi.org/10.1152/ajpcell.00263.2021

Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in interorgan cross talk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin β4 (TMSB4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31fd3fee8e53e53d49591be8655c1af
https://doi.org/10.1152/ajpcell.00263.2021

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