Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Autor: Benoît Souchet, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, Yuchen Gu, Gaelle Dufayet-Chaffaud, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau, Sandro Alves, Laurent Meijer, Nathalie Janel, Jérôme Braudeau, Nathalie Cartier

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer’s disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus witho

Externí odkaz: https://doaj.org/article/78eb540db4c7476bab36dc4843c783a9

Neural Androgen Receptor Deletion Impairs the Temporal Processing of Objects and Hippocampal CA1-Dependent Mechanisms.

Autor: Marie Picot, Jean-Marie Billard, Carlos Dombret, Christelle Albac, Nida Karameh, Stéphanie Daumas, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148328 (2016)

We studied the role of testosterone, mediated by the androgen receptor (AR), in modulating temporal order memory for visual objects. For this purpose, we used male mice lacking AR specifically in the nervous system. Control and mutant males were gona

Externí odkaz: https://doaj.org/article/bc26a2aabf214b059cf623b2ce71d509

Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse

Autor: Glenn Dallérac, Caroline Perronnet, Carine Chagneau, Pascale Leblanc-Veyrac, Nathalie Samson-Desvignes, Elise Peltekian, Olivier Danos, Luis Garcia, Serge Laroche, Jean-Marie Billard, Cyrille Vaillend

Publikováno v: Neurobiology of Disease, Vol 43, Iss 3, Pp 635-641 (2011)

Duchenne muscular dystrophy (DMD) is caused by the absence of dystrophin, a protein that fulfills important functions in both muscle and brain. The mdx mouse model of DMD, which also lacks dystrophin, shows a marked reduction in γ-aminobutyric acid

Externí odkaz: https://doaj.org/article/ad0169baae5b421f99d7a1086b84a657

The NMDA receptor activation by d -serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle

Autor: Marialaura Marchetti, Hazem Safory, Shai Kellner, Simone Engelender, Shai Berlin, Inna Radzishevsky, Veronika N. Foltyn, Samah Neame, Francesco Marchesani, Ayelet Touitou, Jean-Marie Billard, Herman Wolosker

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (41), pp.20736-20742. ⟨10.1073/pnas.1909458116⟩

Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of l-serine from glucose. Astrocytic l-serine was proposed to regulate NMDAR activity by shuttling to neurons to sustain d-serine production, but this h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907772d4c795daf274edd8133a3fc20f
https://doi.org/10.1073/pnas.1909458116

Interplay between 5-HT4 Receptors and GABAergic System within CA1 Hippocampal Synaptic Plasticity

Autor: Elie Brunet, Thomas Freret, Candice M Roux, Pierre Lecouflet, Jean-Marie Billard, Brigitte Potier, Marianne Leger, Pascale Schumann-Bard

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2020, 31 (1), pp.694-701. ⟨10.1093/cercor/bhaa253⟩
Cerebral Cortex, Oxford University Press (OUP), 2021, 31 (1), pp.694-701. ⟨10.1093/cercor/bhaa253⟩
Cerebral Cortex, Oxford University Press (OUP), 2020, ⟨10.1093/cercor/bhaa253⟩
Cerebral Cortex, 2021, 31 (1), pp.694-701. ⟨10.1093/cercor/bhaa253⟩
Cerebral Cortex, 2020, 31 (1), pp.694-701. ⟨10.1093/cercor/bhaa253⟩

The type 4 serotonin receptor (5-HT4R) is highly involved in cognitive processes such as learning and memory. Behavioral studies have shown a beneficial effect of its activation and conversely reported memory impairments by its blockade. However, how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7faaa72e807e1b7a922958a2190ea3cc
https://hal.archives-ouvertes.fr/hal-03040826