Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Marie Arsenian, Henriksson"'
Autor:
Dilraj Lama, Thibault Vosselman, Cagla Sahin, Judit Liaño-Pons, Carmine P. Cerrato, Lennart Nilsson, Kaare Teilum, David P. Lane, Michael Landreh, Marie Arsenian Henriksson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The c-MYC oncogene is activated in over 70% of all human cancers. The intrinsic disorder of the c-MYC transcription factor facilitates molecular interactions that regulate numerous biological pathways, but severely limits efforts to target i
Externí odkaz:
https://doaj.org/article/dc5827f1d64e4af7bed720320a85059d
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c0c030dc1c54c61a794787a99cca008
Autor:
Vittoria Graziani, Aida Rodriguez Garcia, Lourdes Sainero Alcolado, Adrien Le Guennec, Marie Arsenian Henriksson, Maria R. Conte
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Medulloblastoma (MB) is the most common malignant brain tumour in children. High-risk MB patients harbouring MYC amplification or overexpression exhibit a very poor prognosis. Aberrant activation of MYC markedly reprograms cell metabolism to
Externí odkaz:
https://doaj.org/article/cc236716093846ce878ffd2ec238d06c
Autor:
Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina, Marie Arsenian-Henriksson
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-25 (2022)
Abstract Background Neuroblastoma (NB), a childhood tumor derived from the sympathetic nervous system, presents with heterogeneous clinical behavior. While some tumors regress spontaneously without medical intervention, others are resistant to therap
Externí odkaz:
https://doaj.org/article/10125a747c9a43e1aefa23bdaff01c7f
Autor:
Ye Yuan, Mohammad Alzrigat, Aida Rodriguez-Garcia, Xueyao Wang, Tomas Sjöberg Bexelius, John Inge Johnsen, Marie Arsenian-Henriksson, Judit Liaño-Pons, Oscar C. Bedoya-Reina
Publikováno v:
Cancers, Vol 15, Iss 18, p 4599 (2023)
Deregulation of the MYC family of transcription factors c-MYC (encoded by MYC), MYCN, and MYCL is prevalent in most human cancers, with an impact on tumor initiation and progression, as well as response to therapy. In neuroblastoma (NB), amplificatio
Externí odkaz:
https://doaj.org/article/677d2217a9474508b0c2ce4bf4eb4593
Publikováno v:
Communications Physics, Vol 4, Iss 1, Pp 1-9 (2021)
Mechanical ventilation of living animals is routinely used to achieve high-resolution pulmonary imaging, but this can damage the subject. Here, an alternative, free-breathing method enables X-ray tomography with 30 μm resolution.
Externí odkaz:
https://doaj.org/article/e0080e53361543609c9b1e3c2faeb147
Autor:
Luana Naia, Catarina M. Pinho, Giacomo Dentoni, Jianping Liu, Nuno Santos Leal, Duarte M. S. Ferreira, Bernadette Schreiner, Riccardo Filadi, Lígia Fão, Niamh M. C. Connolly, Pontus Forsell, Gunnar Nordvall, Makoto Shimozawa, Elisa Greotti, Emy Basso, Pierre Theurey, Anna Gioran, Alvin Joselin, Marie Arsenian-Henriksson, Per Nilsson, A. Cristina Rego, Jorge L. Ruas, David Park, Daniele Bano, Paola Pizzo, Jochen H. M. Prehn, Maria Ankarcrona
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-s
Externí odkaz:
https://doaj.org/article/4aff891322844c2cbd9f607edd6e7c04
Autor:
Elin Almstedt, Ramy Elgendy, Neda Hekmati, Emil Rosén, Caroline Wärn, Thale Kristin Olsen, Cecilia Dyberg, Milena Doroszko, Ida Larsson, Anders Sundström, Marie Arsenian Henriksson, Sven Påhlman, Daniel Bexell, Michael Vanlandewijck, Per Kogner, Rebecka Jörnsten, Cecilia Krona, Sven Nelander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
We lack effective treatment for half of children with high-risk neuroblastoma. Here, the authors introduce an algorithm that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and id
Externí odkaz:
https://doaj.org/article/9eefbf3ff5bb4e6b9e9c8aacbd9a935c
Autor:
Ganna Oliynyk, María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Johanna Dzieran, Hanna Zirath, Héctor Gallart-Ayala, Craig E. Wheelock, Henrik J. Johansson, Roland Nilsson, Janne Lehtiö, Marie Arsenian-Henriksson
Publikováno v:
iScience, Vol 21, Iss , Pp 188-204 (2019)
Summary: In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients. Identifying the metabolic adaptations crucial for tumor progression may be a promising strategy to di
Externí odkaz:
https://doaj.org/article/30c5f535984240819ada19e400058301
Autor:
Juan Zhang, Graciela Terán, Mihaela Popa, Harsha Madapura, Marcus James Graeme Watson Ladds, Danai Lianoudaki, Jacob Grünler, Marie Arsenian-Henriksson, Emmet McCormack, Martin Enrique Rottenberg, Sergiu-Bogdan Catrina, Sonia Laín, Suhas Darekar
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102494- (2021)
Summary: Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infection
Externí odkaz:
https://doaj.org/article/86552e3185cc4c6e9a16d7f89f5632d2