Hyperpolarized [1‐ 13 C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model

Autor: Hans Stødkilde-Jørgensen, Hans Erik Bøtker, Per Mose Nielsen, Thomas Stokholm Nørlinger, Emmeli Mikkelsen, Marie A. Schroeder, Esben Søvsø Szocska Hansen, Henrik Wiggers, Jakob Lindhardt, Won Yong Kim, Christoffer Laustsen, Lotte Bonde Bertelsen, Rasmus Stilling Tougaard

Publikováno v: Tougaard, R S, Szocska Hansen, E S, Laustsen, C, Nørlinger, T S, Mikkelsen, E, Lindhardt, J, Nielsen, P M, Bertelsen, L B, Schroeder, M, Bøtker, H E, Kim, W Y, Wiggers, H & Stødkilde-Jørgensen, H 2019, ' Hyperpolarized [1-13 C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model ', Magnetic Resonance in Medicine, vol. 81, no. 4, pp. 2655-2665 . https://doi.org/10.1002/mrm.27560

Purpose: Owing to its noninvasive nature, hyperpolarized MRI may improve delineation of myocardial metabolic derangement in heart disease. However, consistency may depend on the changeable nature of cardiac metabolism in relation to whole-body metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66379499359990f02811320d04347fe7
https://doi.org/10.1002/mrm.27560

Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats

Autor: Marie A. Schroeder, Haiyun Qi, Christoffer Laustsen, Per Mose Nielsen, Fredrik Palm, Lotte Bonde Bertelsen

Publikováno v: Qi, H, Nielsen, P M, Schroeder, M, Bertelsen, L B, Palm, F & Laustsen, C 2018, ' Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats ', Diabetologia, vol. 61, no. 2, pp. 445-454 . https://doi.org/10.1007/s00125-017-4445-6

AIMS/HYPOTHESIS: Metformin inhibits hepatic mitochondrial glycerol phosphate dehydrogenase, thereby increasing cytosolic lactate and suppressing gluconeogenesis flux in the liver. This inhibition alters cytosolic and mitochondrial reduction-oxidation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b2a96fb8a9ecedf8d2f378fd605d2e
https://doi.org/10.1007/s00125-017-4445-6

In Vivo Simulation of Magnesium Degradability Using a New Fluid Dynamic Bench Testing Approach

Autor: Frank Walther, Marie-Luise Schroeder, Alexander Kopp, Ole Jung, Frank Feyerabend, Nils Wegner, Dario Porchetta, Mike Barbeck, Martin Klein

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4859 (2019)
Jung, O.; Porchetta, D.; Schroeder, M.-L.; Klein, M.; Wegner, N.; Walther, F.; Feyerabend, F.; Barbeck, M.; Kopp, A.: In vivo simulation of magnesium degradability using a new fluid dynamic bench testing approach. In: International Journal of Molecular Sciences. Vol. 20 (2019) 19, 4859. (DOI: /10.3390/ijms20194859)

The degradation rate of magnesium (Mg) alloys is a key parameter to develop Mg-based biomaterials and ensure in vivo-mechanical stability as well as to minimize hydrogen gas production, which otherwise can lead to adverse effects in clinical applicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c5e8270038292179e7243dd98f3114

Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature

Autor: Rikke Nørregaard, Christian Østergaard Mariager, Haiyun Qi, Marie A. Schroeder, Jakob Lindhardt, Christoffer Laustsen, Janet D. Klein, Per Mose Nielsen, Jeff M. Sands

Publikováno v: Qi, H, Mariager, C Ø, Nielsen, P M, Schroeder, M, Lindhardt, J, Nørregaard, R, Klein, J D, Sands, J M & Laustsen, C 2018, ' Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature ', NMR in Biomedicine, pp. e4028 . https://doi.org/10.1002/nbm.4028

Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694353550dadf9b59e8b19572a8876e3
https://pure.au.dk/portal/da/publications/glucagon-infusion-alters-the-hyperpolarized-13-curea-renal-hemodynamic-signature(d9181c5f-6970-4021-bba2-776f3f9b21ee).html

Determination of the renal concentration capacity following intravenous administration of dDAVP in healthy humans

Autor: Marie K. Schroeder, Birgitte Mahler, Jane H. Christensen, Søren Rittig, Mia Faerch, Konstantinos Kamperis

Publikováno v: Faerch, M, Schroeder, M K, Mahler, B T, Christensen, J H, Kamperis, K & Rittig, S 2018, ' Determination of the renal concentration capacity following intravenous administration of dDAVP in healthy humans ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 78, no. 1-2, pp. 114-119 . https://doi.org/10.1080/00365513.2017.1420215

The synthetic AVP analogue 1-desamino-8-d-arginine-vasopressin (dDAVP) is used for treatment of polyuric disorders. Lack of commercially available assays limits the usefulness of dDAVP as a diagnostic tool in the assessment of renal concentrating cap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7526b7e00d92820f20729db688a444
https://pubmed.ncbi.nlm.nih.gov/29361858