Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Marie‐Pierre Hardy"'
Autor:
Leslie Hesnard, Catherine Thériault, Maxime Cahuzac, Chantal Durette, Krystel Vincent, Marie-Pierre Hardy, Joël Lanoix, Gabriel Ouellet Lavallée, Juliette Humeau, Pierre Thibault, Claude Perreault
Publikováno v:
Current Oncology, Vol 31, Iss 6, Pp 3099-3121 (2024)
Epithelial ovarian cancer (EOC) has not significantly benefited from advances in immunotherapy, mainly because of the lack of well-defined actionable antigen targets. Using proteogenomic analyses of primary EOC tumors, we previously identified 91 abe
Externí odkaz:
https://doaj.org/article/12eb4b94c81d4840bf379764f030a99c
Autor:
Maria Virginia Ruiz Cuevas, Marie-Pierre Hardy, Jean-David Larouche, Anca Apavaloaei, Eralda Kina, Krystel Vincent, Patrick Gendron, Jean-Philippe Laverdure, Chantal Durette, Pierre Thibault, Sébastien Lemieux, Claude Perreault, Grégory Ehx
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-33 (2023)
Abstract MHC-I-associated peptides deriving from non-coding genomic regions and mutations can generate tumor-specific antigens, including neoantigens. Quantifying tumor-specific antigens’ RNA expression in malignant and benign tissues is critical f
Externí odkaz:
https://doaj.org/article/23d904d29bc341d1bcfd3983798d9305
Autor:
Maria Virginia Ruiz Cuevas, Marie-Pierre Hardy, Jaroslav Hollý, Éric Bonneil, Chantal Durette, Mathieu Courcelles, Joël Lanoix, Caroline Côté, Louis M. Staudt, Sébastien Lemieux, Pierre Thibault, Claude Perreault, Jonathan W. Yewdell
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108815- (2021)
Summary: Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the contribution of non-canonical translation to the proteome and major histocompatibility complex (MHC) class I immunopeptidome. Remarkably, of 14,498 protein
Externí odkaz:
https://doaj.org/article/8429cc69806348e1a2f6b013296bbb36
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Intensive fundamental and clinical research in cancer immunotherapy has led to the emergence and evolution of two parallel universes with surprisingly little interactions: the realm of hematologic malignancies and that of solid tumors. Treatment of h
Externí odkaz:
https://doaj.org/article/bf9296f70b2e47b0aaa48ab57da66834
Autor:
Charles St-Pierre, Erwan Morgand, Mohamed Benhammadi, Alexandre Rouette, Marie-Pierre Hardy, Louis Gaboury, Claude Perreault
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2558-2570 (2017)
The sole nonredundant role of the thymic medulla is to induce central tolerance, a vital process that depends on promiscuous gene expression (pGE), a unique feature of medullary thymic epithelial cells (mTECs). Although pGE enhances transcription of
Externí odkaz:
https://doaj.org/article/e10ab17c6b104fe185e19c9ced3d1310
Autor:
Céline M. Laumont, Tariq Daouda, Jean-Philippe Laverdure, Éric Bonneil, Olivier Caron-Lizotte, Marie-Pierre Hardy, Diana P. Granados, Chantal Durette, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC clas
Externí odkaz:
https://doaj.org/article/8e030826a1744d55a142f5a4d3124d1e
Autor:
Etienne Caron, Krystel Vincent, Marie‐Hélène Fortier, Jean‐Philippe Laverdure, Alexandre Bramoullé, Marie‐Pierre Hardy, Grégory Voisin, Philippe P Roux, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-15 (2011)
Abstract Self/non‐self discrimination is a fundamental requirement of life. Endogenous peptides presented by major histocompatibility complex class I (MHC I) molecules represent the essence of self for CD8 T lymphocytes. These MHC I peptides (MIPs)
Externí odkaz:
https://doaj.org/article/889e668107404cfea89f398b2def6704
Autor:
Mélanie Bilodeau, Tara MacRae, Louis Gaboury, Jean-Philippe Laverdure, Marie-Pierre Hardy, Nadine Mayotte, Véronique Paradis, Sébastien Harton, Claude Perreault, Guy Sauvageau
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7500 (2009)
The cystatin protein superfamily is characterized by the presence of conserved sequences that display cysteine protease inhibitory activity (e.g., towards cathepsins). Type 1 and 2 cystatins are encoded by 25 genes of which 23 are grouped in 2 cluste
Externí odkaz:
https://doaj.org/article/88d8c170cbea486a96b875f5750e5aee
Autor:
Noé Guilloy, Marie A. Brunet, Sébastien Leblanc, Jean-François Jacques, Marie-Pierre Hardy, Grégory Ehx, Joël Lanoix, Pierre Thibault, Claude Perreault, Xavier Roucou
Publikováno v:
Journal of Proteome Research. 22:1492-1500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625830f9208c895c16173a087a79aaa6
https://doi.org/10.1021/acs.jproteome.3c00054
https://doi.org/10.1021/acs.jproteome.3c00054
Autor:
Eralda Kina, Jean-Philippe Laverdure, Chantal Durette, Joël Lanoix, Mathieu Courcelles, Qingchuan Zhao, Anca Apavaloaei, Jean-David Larouche, Marie-Pierre Hardy, Krystel Vincent, Patrick Gendron, Leslie Hesnard, Maria Virginia Ruiz Cuevas, Gregory Ehx, Pierre Thibault, Claude Perreault
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ce0c87ddfaa9a36d77aed928c68302
https://doi.org/10.1136/jitc-2022-sitc2022.1411
https://doi.org/10.1136/jitc-2022-sitc2022.1411