Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Marie, Wennerberg"'
Autor:
Anders Hogner, Daniel Lindén, Marlene Fredenwall, Madeleine Antonsson, Anna Pettersen, Peter Brodin, Joachim Persson, Christian Löfberg, Marie Wennerberg, Anders Johansson, Lanna Li, Rolf Bergman, Martin A. Hayes, Karolina Ploj, Robert Judkins, Unge Sverker Von, Peter Gennemark, Lambertus Benthem
Publikováno v:
Journal of Medicinal Chemistry. 59:2497-2511
A novel series of melanin concentrating hormone receptor 1 (MCHr1) antagonists were the starting point for a drug discovery program that culminated in the discovery of 103 (AZD1979). The lead optimization program was conducted with a focus on reducin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c630bda86daddf2212ebabf887061293
https://doi.org/10.1021/acs.jmedchem.5b01654
https://doi.org/10.1021/acs.jmedchem.5b01654
Autor:
Leifeng Cheng, Georges Vauquelin, John C. Clapham, Marie Wennerberg, Stephan Hjorth, Anudharan Balendran
Publikováno v:
Fundamental & Clinical Pharmacology. 25:200-210
The implication of the cannabinoid receptor 1 (CB(1) receptor) in several pathophysiological states has sparked the development of selective antagonists. Here we compare binding of the antagonists [(3) H]-AZ12491187, [(3) H]-taranabant and [(3) H]-ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cf2cd06b8396a8523ece81a4854b5fe
https://doi.org/10.1111/j.1472-8206.2010.00843.x
https://doi.org/10.1111/j.1472-8206.2010.00843.x
Publikováno v:
British Journal of Pharmacology. 161:1311-1328
BACKGROUND AND PURPOSE Because the in vivo effectiveness of ligands may also be determined by the rate by which they dissociate from their target receptors, drug candidates are being increasingly screened for this kinetic property. The dissociation r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a8ad4e722c915e8d82b225d6f2448ea
https://doi.org/10.1111/j.1476-5381.2010.00931.x
https://doi.org/10.1111/j.1476-5381.2010.00931.x
Autor:
Marie Wennerberg, Lars Farde, Maria Sandberg-Ställ, Markus Fridén, Madeleine Antonsson, Magnus Schou
Publikováno v:
EJNMMI Research
Background Development of tracers for imaging with positron emission tomography (PET) is often a time-consuming process associated with considerable attrition. In an effort to simplify this process, we herein propose a mechanistically integrated appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee3180029b677676cbd7c4f0d83a3b4
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260170
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260170
Autor:
Marie, Wennerberg, Leifeng, Cheng, Stephan, Hjorth, John C, Clapham, Anudharan, Balendran, Georges, Vauquelin
Publikováno v:
Fundamentalclinical pharmacology. 25(2)
The implication of the cannabinoid receptor 1 (CB(1) receptor) in several pathophysiological states has sparked the development of selective antagonists. Here we compare binding of the antagonists [(3) H]-AZ12491187, [(3) H]-taranabant and [(3) H]-ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be1a35cc444c2a96d9b23c916b62f757
https://pubmed.ncbi.nlm.nih.gov/20608998
https://pubmed.ncbi.nlm.nih.gov/20608998
Publikováno v:
Fundamental & Clinical Pharmacology.
The dissociation profile of the antagonist [(3)H]-rimonabant from recombinant CB(1) cannabinoid receptors expressed in plated HEK293 cells followed a complex pattern when measured in medium only. After a rapid decline, the specific binding levelled o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb0afd022cb18d1c37c104c57b56d6b
https://doi.org/10.1111/j.1472-8206.2009.00756.x
https://doi.org/10.1111/j.1472-8206.2009.00756.x
Publikováno v:
British journal of pharmacology. 158(1)
Background: β2-adrenoceptor agonists are effective bronchodilators. In vitro studies demonstrated long-lasting airway smooth muscle relaxation by salmeterol after washout, the quick disappearance of this effect in presence of antagonists and its rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea2adb6695f52b2641ce7352fe252bf
https://pubmed.ncbi.nlm.nih.gov/19719780
https://pubmed.ncbi.nlm.nih.gov/19719780
Publikováno v:
Water Research. 8:61-65
The chemical sedimentation of E. coli bacteria has been studied in the presence of polymeric impurities such as occur in domestic waste-water (proteins, lipids, saccharides). Chemical sedimentation was carried out at pH 7 using aluminium sulphate and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87dbfa81b92ee54b28eb0de6dad011e
https://doi.org/10.1016/0043-1354(74)90009-8
https://doi.org/10.1016/0043-1354(74)90009-8