Synthesis and Structural Study of ribo-Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides (ribo-α,β-D-CNA)

Autor: Jean-Marc Escudier, Nathalie Saffon, Dan-Andrei Catana, Pierre Lavedan, Marie Maturano, Corinne Payrastre, Nathalie Tarrat

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2012, pp.721-730. ⟨10.1002/ejoc.201101353⟩
European Journal of Organic Chemistry, 2012, 4, pp.721-730. ⟨10.1002/ejoc.201101353⟩

With increasing interest in the control of the conformations of nucleic acids to define active riboswitch or siRNA, we present herein our efforts towards the stereocontrolled synthesis and conformational analysis of ribodinucleotides in which a and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9ef894199c0c8b68c541f910104474
https://doi.org/10.1002/ejoc.201101353

A chemical model for the enzymatic mono de-alkylation of (methyl and ethyl) parathion by glutathione-S-transferase

Autor: Marie Maturano, Véronique Bongibault, Alain Klaebe, Didier Fournier, Michèle Willson

Publikováno v: Tetrahedron. 53:17241-17246

The NMR study of the reaction of methylparathion with thiol (glutathione) and a tertiary amine shows unambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The reaction stops after a single demethylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9150d608e94cff146af6b9e0e5299cb
https://doi.org/10.1016/s0040-4020(97)10176-4

Synthesis of Phostone-Constrained Nucleic Acid (P-CNA) Dinucleotides Through Intramolecular Arbuzov's Reaction

Autor: Jean-Marc Escudier, Dan-Andrei Catana, Marie Maturano, Nathalie Tarrat, Corinne Payrastre, Pierre Lavedan

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, 2011 (34), pp.6857-6863. ⟨10.1002/ejoc.201101061⟩
European Journal of Organic Chemistry, 2011, 2011 (34), pp.6857-6863. ⟨10.1002/ejoc.201101061⟩

International audience; P‐CNAs are dinucleotide building blocks in which the torsional angles α and β of the sugar/phosphate backbone are constrained to non‐canonical values within a cyclic phosphonate structure (phostone) synthesised by diaste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247104488fb5171ed42ced74f5df2ffd
https://hal.archives-ouvertes.fr/hal-01755334

New potent bisubstrate inhibitors of histone acetyltransferase p300: design, synthesis and biological evaluation

Autor: Franciane Ho A, Kwie, Martine, Briet, David, Soupaya, Pascal, Hoffmann, Marie, Maturano, Frédéric, Rodriguez, Casimir, Blonski, Christian, Lherbet, Cécile, Baudoin-Dehoux

Publikováno v: Chemical biologydrug design. 77(1)

Bisubstrate-type compound Lys-CoA has been shown to inhibit the p300 histone acetyl transferase activity efficiently and may constitute a lead compound for a novel class of anticancer therapeutics. Based on this strategy, we synthesized a series of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0758ccf334a408d7f80ba9cd4d30f043
https://pubmed.ncbi.nlm.nih.gov/21118378

Superoxide-induced bleaching of streptocyanine dyes: Application to assay the enzymatic activity of superoxide dismutases

Autor: Corinne Payrastre, Virginie Vinatier, Pascal Hoffmann, Yves Madaule, Marie Maturano, Valérie Guieu

Publikováno v: Analytical biochemistry. 405(2)

With the aim of developing a novel superoxide dismutase (SOD) activity assay, a series of polymethinium salts (streptocyanines) were prepared and studied for their ability to be reduced by superoxide radical anion generated either from the pyrogallol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23c527056a033b9b8cfd70b59036738
https://pubmed.ncbi.nlm.nih.gov/20570646