Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Maricel Torrent"'
Autor:
Michael Cunningham, Danielle Pins, Zoltán Dezső, Maricel Torrent, Aparna Vasanthakumar, Abhishek Pandey
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract The identification of human proteins that are amenable to pharmacologic modulation without significant off-target effects remains an important unsolved challenge. Computational methods have been devised to identify features which distinguish
Externí odkaz:
https://doaj.org/article/7c390b00d7f64e94b26921de4ddbecdc
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
AR-dependent prostate cancer cell lines are dependent on BET.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f111a5f29806b02929fb08eb34526e
https://doi.org/10.1158/1541-7786.22517328.v1
https://doi.org/10.1158/1541-7786.22517328.v1
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
ABBV-075 inhibits AR-dependent transcription and growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f5225c66061ad6a602a30d2ce0e49c
https://doi.org/10.1158/1541-7786.22517340
https://doi.org/10.1158/1541-7786.22517340
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
ABBV-075 inhibits ETS family member ETV1 target gene transcription.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdc471e8708b7aca8511845326baa08
https://doi.org/10.1158/1541-7786.22517337.v1
https://doi.org/10.1158/1541-7786.22517337.v1
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
Characterization of MDV_R cell line with acquired resistance to Enzalutamide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a571fe9d1ba82a784a6b8f2d6c966c
https://doi.org/10.1158/1541-7786.22517325.v1
https://doi.org/10.1158/1541-7786.22517325.v1
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
Dose-dependent induction of G1 arrest and senescence by ABBV-075.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507223a4db8ebe95d3828b976b255416
https://doi.org/10.1158/1541-7786.22517331.v1
https://doi.org/10.1158/1541-7786.22517331.v1
Autor:
Yu Shen, Warren Kati, Keith McDaniel, Daniel H. Albert, Tamar Uziel, Wei He, Maricel Torrent, Paul Hessler, Xiaoyu Lin, Denise Wilcox, Emily J. Faivre
AR-dependent recruitment of BRD4 to ARE-enhancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e40ae1cb69408a6d15583e5c543f4e
https://doi.org/10.1158/1541-7786.22517334.v1
https://doi.org/10.1158/1541-7786.22517334.v1
Autor:
Daniel H. Albert, Wei Qiu, Chang H. Park, Steven D. Fidanze, Lisa A. Hasvold, Maricel Torrent, Ganesh Rajaraman, Xiaoli Huang, Peter Kovar, Keith F. McDaniel, Xiaoyu Lin, George S. Sheppard, Le Wang, John K. Pratt, Lu Zhang, Mai Bui, Yu Shen, Kenton L. Longenecker, Warren M. Kati, Dachun Liu, Denise Wilcox, Terrance J. Magoc, Emily J. Faivre
Publikováno v:
Journal of Medicinal Chemistry. 63:5585-5623
The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under clinical development for on...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13664ab18da232a44d2b0a2ef1e6c65
https://doi.org/10.1021/acs.jmedchem.0c00628
https://doi.org/10.1021/acs.jmedchem.0c00628
Autor:
Denise Wilcox, Vasudha Sehgal, Daniel H. Albert, John K. Pratt, Keith F. McDaniel, Xin Lu, Chaohong Sun, Dachun Liu, Joshua P. Plotnik, Srinivasa R. Mantena, Emily J. Faivre, Lisa A. Hasvold, George S. Sheppard, Xiaoli Huang, Le Wang, Lance J Bigelow, Stacey Fossey, Steve D. Fidanze, Lloyd T. Lam, Chang H. Park, Sanjay C. Panchal, Warren M. Kati, John J. Nicolette, Richard J. Bellin, Gaurav Mehta, Xiaoyu Lin, Mai H. Bui, Lu Zhang, Paul Hessler, Maricel Torrent, Tamar Uziel, Saul H. Rosenberg, Yu Shen, Kenton L. Longenecker
Publikováno v:
Nature. 578:306-310
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8040bf69aa34810391b9a59139a83026
https://doi.org/10.1038/s41586-020-1930-8
https://doi.org/10.1038/s41586-020-1930-8
Autor:
Velitchka Bontcheva, Maricel Torrent, David Maag, Anthony Mastracchio, Fritz G. Buchanan, Loren M. Lasko, Debra Ferguson, Thomas D. Penning, Alexander R. Shoemaker, Kenneth D. Bromberg, Chunqiu Lai, Eric F. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1481-1486
In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88689f8c707bd9998bf87e5d6b9366a1
https://doi.org/10.1016/j.bmcl.2019.04.017
https://doi.org/10.1016/j.bmcl.2019.04.017