Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Maribel G. Vallespi"'
Publikováno v:
Br J Pharmacol
Peptide‐based cancer therapy has been of great interest due to the unique advantages of peptides, such as their low MW, the ability to specifically target tumour cells, easily available and low toxicity in normal tissues. Therefore, identifying and
Autor:
Maribel G, Vallespi, Braulio, Mestre, Maria A, Marrero, Rolando, Uranga, Diana, Rey, Martha, Lugiollo, Mircea, Betancourt, Kirenia, Silva, Danay, Corrales, Yanet, Lamadrid, Yamilka, Rodriguez, Anaelys, Maceo, Pedro P, Chaviano, Gilda, Lemos, Ania, Cabrales, Freya M, Freyre, Hector, Santana, Hilda E, Garay, Brizaida, Oliva, Julio R, Fernandez
Publikováno v:
International journal of cancerREFERENCES. 149(6)
CIGB-552 is a synthetic peptide that interacts with COMMD1 and upregulates its protein levels. The objectives of this phase I study were safety, pharmacokinetic profile, evaluation of the lymphocytes CD4+ and CD8+ and preliminary activity in patients
Autor:
Lilibet Calaña Seoane, Patricia Alvarez, Osvaldo Reyes, Juan C. Rodriguez, Ibrahim Acosta Cabrera, Maribel G. Vallespi, Hector Santana, Joan Torres Espinosa, Hilda Garay
Publikováno v:
Research in Veterinary Science. 114:502-510
The absence of an effective therapy against human solid tumors has fostered the development of promising antineoplastic therapeutic candidates, as the CIGB-552 peptide. This synthetic peptide has shown to be effective in reducing tumor size and incre
Autor:
Exequiel Barrera, Soledad Astrada, Yolanda Gomez, Gonzalo Obal, Maribel G. Vallespi, Sergio Pantano, Mariela Bollati-Fogolín, Otto Pritsch
Publikováno v:
Journal of Peptide Science. 22:711-722
Because of resistance development by cancer cells against current anticancer drugs, there is a considerable interest in developing novel antitumor agents. We have previously demonstrated that CIGB-552, a novel cell-penetrating synthetic peptide, was
Publikováno v:
Journal of biotechnology. 301
Nuclear Factor kappa B (NF-κB) is a conserved transcription factor involved in the expression of genes that are critical to inflammation and cell survival. Exposure to particular signals results in phosphorylation of NF-κB inhibitor proteins, which
Autor:
Arielis Rodríguez-Ulloa, Osmany Guirola-Cruz, Julio Raúl Fernández Massó, Vladimir Besada Perez, Luis Javier González, Maribel G. Vallespi, Inés Tiscornia, Sabina Victoria, Yassel Ramos Gómez, Teresa Núñez de Villavicencio-Díaz, Mariela Bollati-Fogolín, Brizaida Oliva Arguelles, Yiliam Cruz García, Yasset Perez-Riverol
Publikováno v:
Journal of Proteomics. 126:163-171
The second generation peptide CIGB-552 has a pro-apoptotic effect on H460 non-small cell lung cancer cells and displays a potent cytotoxic effect in HT-29 colon adenocarcinoma cells though its action mechanism is ill defined. Here, we present the fir
Autor:
Osvaldo Reyes, Brizaida Oliva, Iraida Sanchez, Julio Garza, Hilda Garay, Juan C. Rodriguez, Gilmara Pimentel, Osmani Mendoza, Iduna Fichtner, Maria Rivera Markelova, Tais Basaco, Mariela Bollati-Fogolín, Yolanda Gomez, Ania Cabrales-Rico, Carlos F Calderón, Maribel G. Vallespi, Soledad Astrada
Publikováno v:
Journal of Peptide Science. 20:850-859
Accumulation of the COMMD1 protein as a druggable pharmacology event to target cancer cells has not been evaluated so far in cancer animal models. We have previously demonstrated that a second-generation peptide, with cell-penetrating capacity, terme
Autor:
Livan Delgado-Roche, Maribel G. Vallespi, Hilda Garay, Brizaida Oliva Arguelles, Mariela Bollati-Fogolín, Yelaine Tejeda, Julio Raúl Fernández Massó, Osvaldo Reyes, Soledad Astrada
Publikováno v:
Journal of Amino Acids
Journal of Amino Acids, 2013, 2013, pp.251398. ⟨10.1155/2013/251398⟩
Journal of Amino Acids, 2013, 2013, pp.251398. ⟨10.1155/2013/251398⟩
We have demonstrated that the peptide L-2 designed from an alanine scanning of the Limulus-derived LALF32-51 region is a potential candidate for the anticancer therapy and its cell-penetrating capacity is an associated useful property. By the modific
Publikováno v:
Molecules, Vol 23, Iss 4, p 801 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 23; Issue 4; Pages: 801
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 23; Issue 4; Pages: 801
CIGB-552 is a twenty-amino-acid novel synthetic peptide that has proven to be effective in reducing tumor size and increasing lifespan in tumor-bearing mice. Such capability is conferred by its cell-penetrating peptide character, which allows it to e
Autor:
Osmani Mendoza, Hilda Garay, Julio R. Fernández, Boris Acevedo, Gerardo Guillén, Viviana Falcón, Isbel García, Milaid Granadillo, Raimundo Ubieta, Isis Torrens, Maribel G. Vallespi, Osvaldo Reyes
Publikováno v:
Journal of Peptide Science. 16:40-47
Novel therapeutic peptides are increasingly making their way into clinical application. The cationic and amphipathic properties of certain peptides allow them to cross biological membranes in a non-disruptive way without apparent toxicity increasing