Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Maribel Bruno"'
Autor:
Yue Ge, Maribel Bruno, Maliha S Nash, Najwa Haykal Coates, Brian N Chorley, Matthew C Cave, Juliane I Beier
Publikováno v:
Toxicol Sci
Alterations in physiological processes in pancreas have been associated with various metabolic dysfunctions and can result from environmental exposures, such as chemicals and diet. It was reported that environmental vinyl chloride (VC) exposure, a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1223457d42be8d543a3aecd3a8a8b1fd
https://doi.org/10.1093/toxsci/kfad024
https://doi.org/10.1093/toxsci/kfad024
Autor:
Yue Ge, Maribel Bruno, Najwa Haykal-Coates, Kathleen Wallace, Debora Andrews, Adam Swank, Witold Winnik, Jeffrey A Ross
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162522 (2016)
Understanding the mechanisms underlying toxicity initiated by nickel, a ubiquitous environmental contaminant and known human carcinogen is necessary for proper assessment of its risks to human and environment. Among a variety of toxic mechanisms, dis
Externí odkaz:
https://doaj.org/article/abfdfa4f3bc94798884d43bbb0d83cfa
Toxicity pathways have been defined as normal cellular pathways that, when sufficiently perturbed as a consequence of chemical exposure, lead to an adverse outcome. If an exposure alters one or more normal biological pathways to an extent that leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faac2594aac27710e3b1802190f8ef59
https://europepmc.org/articles/PMC6192268/
https://europepmc.org/articles/PMC6192268/
Publikováno v:
Toxicology letters. 264
Hexavalent chromium (Cr (VI)) is an environmental human carcinogen which primarily targets lungs. Among a variety of toxic mechanisms, disruption of biological pathways via translational and post-translational modifications represents a key mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd2fc0b93d45d7e1473689904f8044c
https://pubmed.ncbi.nlm.nih.gov/27592090
https://pubmed.ncbi.nlm.nih.gov/27592090
Autor:
Stephen Nesnow, Rachel D. Grindstaff, Charles E. Wood, Pei-Jen Chen, Lynea Murphy, Yue Ge, Maribel Bruno, Guy R. Lambert, William T. Padgett
Publikováno v:
Chemico-Biological Interactions. 194:79-89
Propiconazole induces hepatocellular carcinomas and hepatocellular adenomas in mice and promotes liver tumors in rats. Transcriptional, proteomic, metabolomic and biochemical studies of hepatic tissues from mice treated with propiconazole under the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7db0c56fb49a6d7b6c5b5d9e2c9eac6
https://doi.org/10.1016/j.cbi.2011.08.002
https://doi.org/10.1016/j.cbi.2011.08.002
Publikováno v:
PROTEOMICS. 11:2406-2422
Oxidative stress is known to play important roles in engineered nanomaterial-induced cellular toxicity. However, the proteins and signaling pathways associated with the engineered nanomaterial-mediated oxidative stress and toxicity are largely unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a35989a02ac6dc7e9d5da981b447d3
https://doi.org/10.1002/pmic.201000741
https://doi.org/10.1002/pmic.201000741
Autor:
Maribel Bruno, Darrell W. Winsett, Aimen K. Farraj, Allen D. Ledbetter, Andy Ghio, Christina M. Lamb, Yue Ge, Daniel L. Costa, Alex P. Carll, Mehdi S. Hazari, Najwa Haykal-Coates
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:185-196
Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347d182b4af22dcef76e5bfc078a713c
https://doi.org/10.1165/rcmb.2009-0456oc
https://doi.org/10.1165/rcmb.2009-0456oc
Publikováno v:
Journal of Proteome Research. 8:2070-2078
Propiconazole, a widely used fungicide, is hepatotoxic and hepatotumorigenic in mice. Previous genomic analysis of liver tissues from propiconazole-treated mice identified genes and pathways involved in oxidative stress, suggesting that oxidative str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0b75407304d499c6ffafc15fe22512
https://doi.org/10.1021/pr801061r
https://doi.org/10.1021/pr801061r
Autor:
Rick Irwin, Assunta-Susanna Sansone, Michael J. Waters, Michael L. Cunningham, Wenjun Bao, Weida Tong, Jennifer H. Madenspacher, Ann M. Richard, Atif Hasan, Danielle Choi, Norman Morrison, B. Alex Merrick, William Eastin, Roger Brown, Asif Rashid, Jennifer Fostel, Richard S. Paules, Pierre R. Bushel, Chihae Yang, Philippe Rocca-Serra, Thomas Papoian, Alex Garcia, James L. Stevens, Maribel Bruno, David J. Dix, Carlos Frade, Kenneth B. Tomer, Craig Zwickl, Alexandra N. Heinloth
Publikováno v:
Toxicological Sciences. 88:585-601
A critical component in the design of the Chemical Effects in Biological Systems (CEBS) Knowledgebase is a strategy to capture toxicogenomics study protocols and the toxicity endpoint data (clinical pathology and histopathology). A Study is generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c1cdc2602152f93066bff0b1ba96ef
https://doi.org/10.1093/toxsci/kfi315
https://doi.org/10.1093/toxsci/kfi315
Autor:
Maribel Bruno, Sandra M. Ward, Stella O. Sieber, J. Todd Auman, B. Alex Merrick, Richard S. Paules, Charles J. Tucker, Rick D. Fannin
Publikováno v:
Physiological Genomics. 21:92-104
Microarrays have been used to evaluate the expression of thousands of genes in various tissues. However, few studies have investigated the change in gene expression profiles in one of the most easily accessible tissues, whole blood. We utilized an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf0055a50f31321b7d4cfa8cabdbb66
https://doi.org/10.1152/physiolgenomics.00190.2004
https://doi.org/10.1152/physiolgenomics.00190.2004