Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Mariateresa Allocca"'
1
Akademický článek
Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease
Autor: Ryan C Vignogna, Mariateresa Allocca, Maria Monticelli, Joy W Norris, Richard Steet, Ethan O Perlstein, Giuseppina Andreotti, Gregory I Lang
Publikováno v: eLife, Vol 11 (2022)
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2, which affect protein N-linked glycosylation. The yeast gene SEC53 encodes a homolog of human PMM2. We evolved 384 population
Externí odkaz: https://doaj.org/article/12fb21d1e1c5435787fcfc54b0ca4d30
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2
Akademický článek
Bioinformatics tools for marine biotechnology: a practical tutorial with a metagenomic approach
Autor: Ludovica Liguori, Maria Monticelli, Mariateresa Allocca, Maria Vittoria Cubellis, Bruno Hay Mele
Publikováno v: BMC Bioinformatics, Vol 21, Iss S10, Pp 1-15 (2020)
Abstract Background Bioinformatics has pervaded all fields of biology and has become an indispensable tool for almost all research projects. Although teaching bioinformatics has been incorporated in all traditional life science curricula, practical h
Externí odkaz: https://doaj.org/article/a5117604beca41bcbd3524fe33bab113
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3
Akademický článek
Drosophila melanogaster: A Model Organism to Study Cancer
Autor: Zhasmine Mirzoyan, Manuela Sollazzo, Mariateresa Allocca, Alice Maria Valenza, Daniela Grifoni, Paola Bellosta
Publikováno v: Frontiers in Genetics, Vol 10 (2019)
Cancer is a multistep disease driven by the activation of specific oncogenic pathways concomitantly with the loss of function of tumor suppressor genes that act as sentinels to control physiological growth. The conservation of most of these signaling
Externí odkaz: https://doaj.org/article/88c7e93481ea432ca75822d852316b5c
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4
Akademický článek
Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4′-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors
Autor: Alessandro Dessì, Paola Peluso, Roberto Dallocchio, Robin Weiss, Giuseppina Andreotti, Mariateresa Allocca, Emmanuel Aubert, Patrick Pale, Victor Mamane, Sergio Cossu
Publikováno v: Molecules, Vol 25, Iss 9, p 2213 (2020)
The 3,3′,5,5′-tetrachloro-2-iodo-4,4′-bipyridine structure is proposed as a novel chemical scaffold for the design of new transthyretin (TTR) fibrillogenesis inhibitors. In the frame of a proof-of-principle exploration, four chiral 3,3′,5,5
Externí odkaz: https://doaj.org/article/3853a7b5636c475db178f56d6a65fd30
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5
A Community-Based Participatory Framework to Co-Develop Patient Education Materials (PEMs) for Rare Diseases: A Model Transferable across Diseases
Autor: Marta Falcão, Mariateresa Allocca, Ana Sofia Rodrigues, Pedro Granjo, Rita Francisco, Carlota Pascoal, Maria Grazia Rossi, Dorinda Marques-da-Silva, Salvador C. M. Magrinho, Jaak Jaeken, Larisa Aragon Castro, Cláudia de Freitas, Paula A. Videira, Luísa de Andrés-Aguayo, Vanessa dos Reis Ferreira
Publikováno v: International Journal of Environmental Research and Public Health; Volume 20; Issue 2; Pages: 968
At least 50% of chronic disease patients don't follow their care plans, leading to lower health outcomes and higher medical costs. Providing Patient Education Materials (PEMs) to individuals living with a disease can help to overcome these problems.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b8c3b4c4315c408392435a24de7c81
https://lirias.kuleuven.be/handle/20.500.12942/714764
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7
Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones
Autor: Maria Monticelli, Ludovica Liguori, Mariateresa Allocca, Andrea Bosso, Giuseppina Andreotti, Jan Lukas, Maria Chiara Monti, Elva Morretta, Maria Vittoria Cubellis, Bruno Hay Mele
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 5105
Fabry disease is caused by a deficiency of lysosomal alpha galactosidase and has a very large genotypic and phenotypic spectrum. Some patients who carry hypomorphic mutations can benefit from oral therapy with a pharmacological chaperone. The drug re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1746774812519fcd7a0dea701e925eaa
https://pubmed.ncbi.nlm.nih.gov/35563496
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8
Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase
Autor: Ryan C. Vignogna, Mariateresa Allocca, Maria Monticelli, Joy W. Norris, Richard Steet, Giuseppina Andreotti, Ethan O. Perlstein, Gregory I. Lang
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2, which affect protein N-linked glycosylation. The yeast gene SEC53 encodes a nearly-identical homolog of human PMM2. We evolv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aff7d2f4a29fe2c1d62f99eb50b8b028
https://doi.org/10.1101/2022.04.06.487342
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9
Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4′-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors
Autor: Paola Peluso, Roberto Dallocchio, Sergio Cossu, Mariateresa Allocca, Emmanuel Aubert, Giuseppina Andreotti, Alessandro Dessì, Victor Mamane, Robin Weiss, Patrick Pale
Publikováno v: Molecules, Vol 25, Iss 2213, p 2213 (2020)
Molecules
Volume 25
Issue 9
Molecules, MDPI, 2020, 25 (9), pp.2213. ⟨10.3390/molecules25092213⟩
Molecules (Basel, Online) 15 (2020): 2213. doi:10.3390/molecules25092213
info:cnr-pdr/source/autori:Alessandro Dessì, Paola Peluso, Roberto Dallocchio, Robin Weiss, Giuseppina Andreotti, Mariateresa Allocca, Emmanuel Aubert, Patrick Pale, Victor Mamane, Sergio Cossu/titolo:Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4'-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors/doi:10.3390%2Fmolecules25092213/rivista:Molecules (Basel, Online)/anno:2020/pagina_da:2213/pagina_a:/intervallo_pagine:2213/volume:15
The 3,3&prime
5,5&prime
tetrachloro-2-iodo-4,4&prime
bipyridine structure is proposed as a novel chemical scaffold for the design of new transthyretin (TTR) fibrillogenesis inhibitors. In the frame of a proof-of-principle exploration,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c067cd0e3e1f60eb6228b5829042b29d
https://www.mdpi.com/1420-3049/25/9/2213
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