Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Mariarosaria Bucci"'
Autor:
Silvia Marchianò, Michele Biagioli, Martina Bordoni, Elva Morretta, Cristina Di Giorgio, Valentina Vellecco, Rosalinda Roselli, Rachele Bellini, Carmen Massa, Luigi Cari, Ginevra Urbani, Patrizia Ricci, Maria Chiara Monti, Antonino Giordano, Vincenzo Brancaleone, Mariarosaria Bucci, Angela Zampella, Eleonora Distrutti, Enrico Cieri, Giuseppe Cirino, Stefano Fiorucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023)
Background Patients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. FXR and GPBAR1 are 2 bile acid–activated receptors exploited in the treatment of nonalcoholic fatty liver disease: w
Externí odkaz:
https://doaj.org/article/e9d3bf92020f42c1aa2371c79a9f989c
Autor:
Valentina Vellecco, Erika Esposito, Chiara Indolfi, Anella Saviano, Elisabetta Panza, Mariarosaria Bucci, Vincenzo Brancaleone, Giuseppe Cirino, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino, Emma Mitidieri
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115536- (2023)
This study investigates the inflammatory response to intra-plantar injection of L-cysteine in a murine model. L-cysteine induces a two-phase response: an early phase lasting 6 h and a late phase peaking at 24 h and declining by 192 h. The early phase
Externí odkaz:
https://doaj.org/article/d2cfae5a49554c949319249cac16d22c
Autor:
Rosangela Montanaro, Valentina Vellecco, Roberta Torregrossa, Gian Marco Casillo, Onorina Laura Manzo, Emma Mitidieri, Mariarosaria Bucci, Sigismondo Castaldo, Raffaella Sorrentino, Matthew Whiteman, Martina Smimmo, Flavia Carriero, Giuseppe Terrazzano, Giuseppe Cirino, Roberta d’Emmanuele di Villa Bianca, Vincenzo Brancaleone
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102657- (2023)
Diabetes is associated with severe vascular complications involving the impairment of endothelial nitric oxide synthase (eNOS) as well as cystathionine γ-lyase (CSE) activity. eNOS function is suppressed in hyperglycaemic conditions, resulting in re
Externí odkaz:
https://doaj.org/article/cfd68478f66f44dd8c2212be1e351e68
Autor:
Antonella Virgilio, Daniela Benigno, Carla Aliberti, Valentina Vellecco, Mariarosaria Bucci, Veronica Esposito, Aldo Galeone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15529 (2023)
Thrombin-binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers. By adopting its peculiar chair-like G4 structure, TBA can efficiently bind to thrombin, thus producing an anticoagulant effect. The major limit to its therape
Externí odkaz:
https://doaj.org/article/6a75b8c3905a41229b7d777978f38eb0
Autor:
Antonia Katsouda, Maria Markou, Paraskevas Zampas, Aimilia Varela, Constantinos H. Davos, Valentina Vellecco, Giuseppe Cirino, Mariarosaria Bucci, Andreas Papapetropoulos
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Hydrogen sulfide (H2S), a gasotransmitter with protective effects in the cardiovascular system, is endogenously generated by three main enzymatic pathways: cystathionine gamma lyase (CTH), cystathionine beta synthase (CBS) and 3-mercaptopyruvate sulf
Externí odkaz:
https://doaj.org/article/25e580091e414ea09b241eaa8d40a23f
Autor:
Elisabetta Panza, Ivana Bello, Martina Smimmo, Vincenzo Brancaleone, Emma Mitidieri, Mariarosaria Bucci, Giuseppe Cirino, Raffaella Sorrentino, Roberta d′Emmanuele di Villa Bianca
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 151, Iss , Pp 113137- (2022)
The role of H2S in urothelial carcinoma (UC) is still unclear. Here we have evaluated the expression of H2S producing enzymes as well as the effect of endogenous and exogenous H2S on human bladder UC cells. In human UC cells the expression of cystath
Externí odkaz:
https://doaj.org/article/37a33380f8c2437a99ac41d391b8922a
Autor:
Veronica Esposito, Daniela Benigno, Ivana Bello, Elisabetta Panza, Mariarosaria Bucci, Antonella Virgilio, Aldo Galeone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9524 (2023)
In this paper, we investigate the structural and biological features of G-quadruplex (G4) aptamers as promising antiproliferative compounds affecting the STAT3 signalling pathway. Targeting the STAT3 protein through high-affinity ligands to reduce it
Externí odkaz:
https://doaj.org/article/cd610a20688f45cfa2008c43a293de3f
Autor:
Ivana Bello, Martina Smimmo, Roberta d’Emmanuele di Villa Bianca, Mariarosaria Bucci, Giuseppe Cirino, Elisabetta Panza, Vincenzo Brancaleone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6764 (2023)
Breast cancer is the most frequent form of cancer occurring in women of any age. Among the different types, the triple-negative breast cancer (TNBC) subtype is recognized as the most severe form, being associated with the highest mortality rate. Curr
Externí odkaz:
https://doaj.org/article/7d39458c30cc4a509ea277c634b8e60a
Autor:
Valentina Vellecco, Elisabetta Panza, Sofia-Iris Bibli, Gian Marco Casillo, Federica Raucci, Onorina Laura Manzo, Martina Smimmo, Romolo Villani, Maria Rosaria Cavezza, Ingrid Fleming, Roberta d'Emmanuele di Villa Bianca, Francesco Maione, Giuseppe Cirino, Mariarosaria Bucci
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106108- (2022)
The increase in intracellular calcium is influenced by cyclic nucleotides (cAMP and cGMP) content, which rating is governed by phosphodiesterases (PDEs) activity.Despite it has been demonstrated a beneficial effect of PDEs inhibitors in different pat
Externí odkaz:
https://doaj.org/article/57c8ce1cd819431d804e29a15c9e82be
Autor:
Francesco Maione, Gian Marco Casillo, Federica Raucci, Cristian Salvatore, Giovanna Ambrosini, Luisa Costa, Raffaele Scarpa, Francesco Caso, Mariarosaria Bucci
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111980- (2021)
One of the hallmarks of COVID-19 is the cytokine storm that provokes primarily pneumonia followed by systemic inflammation. Emerging evidence has identified a potential link between elevated interleukin-17A (IL-17A) levels and disease severity and pr
Externí odkaz:
https://doaj.org/article/fab50d1071414697932343b6e8262b1f