Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Mariapia A. Degli-Esposti"'
Autor:
Harrison Sudholz, Iona S. Schuster, Momeneh Foroutan, Xavier Sng, Christopher E. Andoniou, Anh Doan, Tania Camilleri, Zihan Shen, Colby Zaph, Mariapia A. Degli-Esposti, Nicholas D. Huntington, Sebastian Scheer
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114333- (2024)
Summary: Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role in natural killer (NK) cell biology within the tumor microenvironment (TME) remains largely unknown. We demonstrate that the HMT DOT1L limits NK ce
Externí odkaz:
https://doaj.org/article/c8754c39626e43d7815160610c1f2491
Autor:
Wilford Goh, Sebastian Scheer, Jacob T. Jackson, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Iona S. Schuster, Christopher E. Andoniou, Jai Rautela, Mariapia A. Degli-Esposti, Melissa J. Davis, Matthew P. McCormack, Stephen L. Nutt, Nicholas D. Huntington
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108285- (2020)
Summary: Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cel
Externí odkaz:
https://doaj.org/article/2bef8f5daa1043aaa96cbe75ddc3a29d
Autor:
Sam Sheppard, Iona S. Schuster, Christopher E. Andoniou, Clement Cocita, Thomas Adejumo, Sam K.P. Kung, Joseph C. Sun, Mariapia A. Degli-Esposti, Nadia Guerra
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3385-3392 (2018)
Summary: TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK) cells, where it contributes to NK cell anti-tumor, anti-viral, and immunoregulatory fun
Externí odkaz:
https://doaj.org/article/070be39fed8543abb9f36404fb76216c
Autor:
Nicola Ferreira, Christopher E Andoniou, Kara L Perks, Judith A Ermer, Danielle L Rudler, Giulia Rossetti, Ambika Periyakaruppiah, Jamie K Y Wong, Oliver Rackham, Peter G Noakes, Mariapia A Degli-Esposti, Aleksandra Filipovska
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008604 (2020)
The influence of environmental insults on the onset and progression of mitochondrial diseases is unknown. To evaluate the effects of infection on mitochondrial disease we used a mouse model of Leigh Syndrome, where a missense mutation in the Taco1 ge
Externí odkaz:
https://doaj.org/article/4c2f6a2af5f1410aad89e487d9251e55
Autor:
Komi Gbedande, Samad A. Ibitokou, Monique L. Ong, Mariapia A. Degli-Esposti, Michael G. Brown, Robin Stephens
Publikováno v:
bioRxiv
Vaccines to persistent parasite infections have been challenging, and current iterations lack long-term protection. Cytomegalovirus(CMV) chronic vaccine vectors drive protection against SIV, tuberculosis and liver-stage malaria correlated with antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cdd4395e24ad046648bd01123f79cf
https://europepmc.org/articles/PMC10187235/
https://europepmc.org/articles/PMC10187235/
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
Supplementary Figure S1: GVHD survival of lethally-irradiated (day 0, 1000cGy split dose) B6.WT, B6.ASC-/- or B6.NLRP3-/- recipients transplanted with BALB/c BM (5x106) and T cells (5x106). The non-GVHD control group received TCD BM cells (5x106) onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c670406bdd6e90ec2d85cea9452ca1
https://doi.org/10.1158/2326-6066.22543108
https://doi.org/10.1158/2326-6066.22543108
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7145b9fd80a40cc0741b069c6d960d1
https://doi.org/10.1158/2326-6066.c.6550138.v1
https://doi.org/10.1158/2326-6066.c.6550138.v1
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
Supplementary Table S1 (related to Fig. 4A): (A) Ingenuity Pathway Analysis derived from the uncorrected dataset displaying top canonical signaling pathways involving differentially regulated genes in recipients as described in Fig.4A. (B) 10 selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b81f04af8f07416c8522368ebdbf6e4
https://doi.org/10.1158/2326-6066.22543105.v1
https://doi.org/10.1158/2326-6066.22543105.v1
Autor:
Mark J. Smyth, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Joel Linden, Nicola Waddell, Eric Vivier, Mariapia A. Degli-Esposti, Laurence Zitvogel, Kimberley A. Stannard, Jerome D. Coudert, Gene Lin, Meriem Messaoudene, Deborah S. Barkauskas, Ann-Marie Patch, Yulong Gao, Shin Foong Ngiow, Arabella Young
Figure S1. Liver ILC1s express high levels of adenosine-related molecules. Figure S2. A2AR-deficient NK cells display enhanced competitive proliferation. Figure S3. NK cell specific deletion of the A2AR provides improved proliferative capacity. Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa890eb6d437e408e7414fe1c7a71ec
https://doi.org/10.1158/0008-5472.22420202
https://doi.org/10.1158/0008-5472.22420202
Autor:
Geoffrey R. Hill, Steven W. Lane, Mariapia A. Degli-Esposti, Thomas Brocker, Gabrielle T. Belz, Raymond J. Steptoe, Mark J. Smyth, Motoko Koyama, Melody Cheong, Simone A. Minnie, Andrea S. Henden, J. Paulo Martins, Renee J. Robb, Kate H. Gartlan, Daniel J. Browne, Rachel D. Kuns, Kate A. Markey
Supplementary table 1: Supplementary Table 1: Gene expression measured in QIAGEN Apoptosis Array; Supplementary Table 2: Antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042dfc3f266b06f081aef1749f01cb6a
https://doi.org/10.1158/1078-0432.22464882.v1
https://doi.org/10.1158/1078-0432.22464882.v1