Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mariantonietta Forgione"'
Autor:
Chiara Fulci, Dante Rotili, Anastasia De Luca, Lorenzo Stella, Blasco Morozzo della Rocca, Mariantonietta Forgione, Veronica Di Paolo, Antonello Mai, Mattia Falconi, Luigi Quintieri, Anna M. Caccuri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 240-247 (2017)
Context: The nitrobezoxadiazole derivative NBDHEX is a potent inhibitor of glutathione transferase P1-1 (GSTP1-1) endowed with outstanding anticancer activity in different tumor models. Objective: To characterize by in vitro biochemical and in silico
Externí odkaz:
https://doaj.org/article/3789f8d2549b4ac8b31477f4b3596ba3
Autor:
Emmanuele Crespan, Giovanni Maga, Roberto Cirilli, Antonello Mai, Cristina Panella, Mariantonietta Forgione, Alessia Lucidi, Ivan A Kirillov, Rino Ragno, Eva Riveira-Muñoz, Alexandros Patsilinakos, Roger Badia, José A. Esté, M. B. Nawrozkij, Dante Rotili, Gebremedhin Solomon Hailu, Jorge I. Armijos Rivera, Daniela Tomaselli, Alexandre S. Yablokov
Conformational restriction applied to dihydrobenzylpyrimidin-4-(3 H)-ones (DABOs) by the intoduction of a methyl group at the α-benzylic position is known to massively improve the anti-HIV-1 activity of these compounds. Here, we report the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e062e9892982201c1b9fd3bc2ef101
http://hdl.handle.net/11573/1221842
http://hdl.handle.net/11573/1221842
Autor:
Dante Rotili, Simona Pilotto, Biagina Marrocco, Andrea Mattevi, Alessia Lucidi, Giuseppe Ciossani, Parinaz Mehdipour, Antonello Mai, Federico Forneris, Valentina Speranzini, Mariantonietta Forgione, Sameer Velankar
Publikováno v:
Science Advances
'Science Advances ', vol: 2, pages: e1601017-1-e1601017-8 (2016)
'Science Advances ', vol: 2, pages: e1601017-1-e1601017-8 (2016)
The binding mode of newly discovered histone demethylase inhibitors could have applications in the design and repurposing of drugs.
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylas
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5025aba3f2ce56af227b3d5f10b941ce
https://pubmed.ncbi.nlm.nih.gov/27626075
https://pubmed.ncbi.nlm.nih.gov/27626075
Autor:
Camilla Palumbo, Mariantonietta Forgione, Anastasia De Luca, Dante Rotili, Nicola Rosato, Anna Maria Caccuri
Publikováno v:
Journal of Translational Medicine
Background Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and ability to sequester TNF-recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62836e4c3584409f7c5c1c679c18d260
http://hdl.handle.net/2108/217466
http://hdl.handle.net/2108/217466
Autor:
Mariantonietta Forgione, Enrica Serretiello, Vincenzo Carafa, Dante Rotili, Gebremedhin Solomon Hailu, Lucia Altucci, Elina M. Jarho, Antonello Mai, Francesca Cuomo, Maija Lahtela-Kakkonen
Publikováno v:
Clinical epigenetics (Internet) 8 (2016): 8–61. doi:10.1186/s13148-016-0224-3
info:cnr-pdr/source/autori:Carafa V.; Rotili D.; Forgione M.; Cuomo F.; Serretiello E.; Hailu G.S.; Jarho E.; Lahtela-Kakkonen M.; Mai A.; Altucci L./titolo:Sirtuin functions and modulation: from chemistry to the clinic/doi:10.1186%2Fs13148-016-0224-3/rivista:Clinical epigenetics (Internet)/anno:2016/pagina_da:8/pagina_a:61/intervallo_pagine:8–61/volume:8
Clinical Epigenetics
info:cnr-pdr/source/autori:Carafa V.; Rotili D.; Forgione M.; Cuomo F.; Serretiello E.; Hailu G.S.; Jarho E.; Lahtela-Kakkonen M.; Mai A.; Altucci L./titolo:Sirtuin functions and modulation: from chemistry to the clinic/doi:10.1186%2Fs13148-016-0224-3/rivista:Clinical epigenetics (Internet)/anno:2016/pagina_da:8/pagina_a:61/intervallo_pagine:8–61/volume:8
Clinical Epigenetics
Article
Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair,
Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46e9ab35f919c245b55d507c96db762
https://erepo.uef.fi/handle/123456789/135
https://erepo.uef.fi/handle/123456789/135
Autor:
Anna Maria Caccuri, Antonello Mai, Silvia Pezzola, Domenico Tarantino, Blasco Morozzo della Rocca, Mattia Falconi, Dante Rotili, Mariantonietta Forgione, Anastasia De Luca
The 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX, 1), a "suicide inhibitor" of the glutathione-S-transferase GSTP1-1, showed pro-apoptotic properties in tumor cells, but in vivo studies were limited by poor bioavailability and hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1147546181833be54614eeec5938b44e
http://hdl.handle.net/2108/113691
http://hdl.handle.net/2108/113691