Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mariantonia Costanza"'
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam A. Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Fischer, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction
Externí odkaz:
https://doaj.org/article/89617bbfc2d9437a8c22b2474e5ec08c
Autor:
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−
Externí odkaz:
https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b
Autor:
Luca Mologni, Mariantonia Costanza, Geeta Geeta Sharma, Michela Viltadi, Luca Massimino, Stefania Citterio, Stefania Purgante, Hima Raman, Alessandra Pirola, Massimo Zucchetti, Rocco Piazza, Carlo Gambacorti-Passerini
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 467-477 (2018)
BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with
Externí odkaz:
https://doaj.org/article/587bd5dbf8d14faa9c7a97a42de419da
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Pfaus, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
SUMMARY PARAGRAPHDisease-causing mutations in genes encoding transcription factors (TFs) are a recurrent finding in hematopoietic malignancies and might involve key regulators of lineage adherence and cellular differentiation1–3. Such mutations can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd3316c398bb4961ae21419171bf62ab
https://doi.org/10.1101/2022.12.29.522203
https://doi.org/10.1101/2022.12.29.522203
Autor:
Stephan Kreher, Lukas Kenner, Kathrin D Wurster, Olaf Merkel, Nikolai Schleussner, Arjan Diepstra, Reiner Siebert, Bernd Gillissen, Ioannis Anagnostopoulos, Mariantonia Costanza, Selina Glaser, Björn Lamprecht, Arturo Molina, Karl Köchert, Harald Stein, Korinna Jöhrens, Michael Hummel, Martin Janz, Stephan Mathas
Publikováno v:
Cancers
Volume 13
Issue 19
Cancers, 13(19):5012. MDPI AG
Cancers, Vol 13, Iss 5012, p 5012 (2021)
Volume 13
Issue 19
Cancers, 13(19):5012. MDPI AG
Cancers, Vol 13, Iss 5012, p 5012 (2021)
In 50–60% of cases, systemic anaplastic large cell lymphoma (ALCL) is characterized by the t(2
5)(p23
q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events
5)(p23
q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events
Autor:
Geeta G. Sharma, Luca Massimino, Luca Mologni, Hima Raman, Mariantonia Costanza, Alessandra Pirola, Michela Viltadi, Stefania Citterio, Stefania Purgante, Rocco Piazza, Massimo Zucchetti, Carlo Gambacorti-Passerini
Publikováno v:
Neoplasia
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 467-477 (2018)
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 467-477 (2018)
BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with
Autor:
Mariantonia Costanza, Wilhelm Woessmann, Claus Scheidereit, Suzanne D. Turner, Michael Hummel, Stephan Mathas, Linda von Hoff, Georg Lenz, Michael Grau, Antonia Niedobitek, Christian Hinze, Henrike L Sczakiel, Chiara Romagnani, Christine Damm-Welk, Franziska Hummel, Bernd Dörken, Korinna Jöhrens, Olaf Merkel, Huan-Chang Liang, Patrick R. Griffin, Martin Janz, Bernd Gillissen, Roberto Piva, Ioannis Anagnostopoulos, Dagmar Stoiber, Eva Kaergel, Pawel Durek, Lukas Kenner, Nikolai Schleussner
Publikováno v:
Leukemia
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK(+) and ALK(–) anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind classical AP-1 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a31559cec1df4c83d4f1852b904093
https://www.repository.cam.ac.uk/handle/1810/274128
https://www.repository.cam.ac.uk/handle/1810/274128