Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Mariano Severgnini"'
Autor:
Tamara A. Sussman, Mariano Severgnini, Anita Giobbie-Hurder, Philip Friedlander, Scott J. Swanson, Michael Jaklitsch, Thomas Clancy, Laura A. Goguen, David Lautz, Richard Swanson, Heather Daley, Jerome Ritz, Glenn Dranoff, F. Stephen Hodi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundIn the era of immune checkpoint blockade, the role of cancer vaccines in immune priming has provided additional potential for therapeutic improvements. Prior studies have demonstrated delayed type hypersensitivity and anti-tumor immunity wi
Externí odkaz:
https://doaj.org/article/ba235126d5b84090b4b832fedad15dec
Autor:
Daniel J DeAngelo, Chia-Cheng Li, Amit Verma, Mariano Severgnini, David Nickle, Guillermo Garcia-Manero, Uwe Platzbecker, Reinhard von Roemeling, Klaus H Metzeler, Eric S Winer, Gaurav S Choudhary, Wanying Zhao, Maureen Lane, Alyssa Masciarelli, Dora Ferrari, Cole Gallagher, Samantha Carlisle
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/2e667ab0e236414281a1be5dcc4a281e
Autor:
Garrett S. Dunlap, Daniel DiToro, Joel Henderson, Sujal I. Shah, Mike Manos, Mariano Severgnini, Astrid Weins, Indira Guleria, Patrick A. Ott, Naoka Murakami, Deepak A. Rao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Immune checkpoint inhibitors (ICI) may have unanticipated side effects in transplant recipients who subsequently develop tumors. Here the authors used single-cell sequencing to identify and characterize allogeneic reactive T cells that developed afte
Externí odkaz:
https://doaj.org/article/e991277fef0d4954afa3894a6cef86f7
Autor:
Tanya E. Keenan, Jennifer L. Guerriero, Romualdo Barroso-Sousa, Tianyu Li, Tess O’Meara, Anita Giobbie-Hurder, Nabihah Tayob, Jiani Hu, Mariano Severgnini, Judith Agudo, Ines Vaz-Luis, Leilani Anderson, Victoria Attaya, Jihye Park, Jake Conway, Meng Xiao He, Brendan Reardon, Erin Shannon, Gerburg Wulf, Laura M. Spring, Rinath Jeselsohn, Ian Krop, Nancy U. Lin, Ann Partridge, Eric P. Winer, Elizabeth A. Mittendorf, David Liu, Eliezer M. Van Allen, Sara M. Tolaney
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
A randomized phase 2 clinical trial has recently shown no benefit of the combination eribulin and pembrolizumab over pembrolizumab alone in HR + metastatic breast cancer patients (NCT03051659). Here, the authors are reporting the final OS data and bi
Externí odkaz:
https://doaj.org/article/d25f24d7eb06482f96ec27595b0111bc
Autor:
Charlotte Abrecht, Margaret Hallisey, Jenna Dennis, Matthew Nazzaro, Martha Brainard, Emma Hathaway, Abigail N. Schork, F. Stephen Hodi, Mariano Severgnini, Joanna Baginska
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101362- (2022)
Summary: With the increasing use of mass cytometry in clinical research, a simplified and standardized protocol for immunophenotyping human peripheral blood mononuclear cells (PBMCs) in clinical trials is needed. We present a simplified in-plate stai
Externí odkaz:
https://doaj.org/article/71f8a2b5c4e5419b9c5012dd0f42c434
Autor:
Howard Streicher, Elad Sharon, Mariano Severgnini, Michael Manos, Anita Giobbie-Hurder, F Stephen Hodi, Andrew S Brohl, Philippe L Bedard, Kevin Tyan, Scott Rodig, Osama E Rahma, Daniel J Renouf, Emma Hathaway, Rachel Cunningham
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background The combination of antiangiogenic agents with immune checkpoint inhibitors could potentially overcome immune suppression driven by tumor angiogenesis. We report results from a phase IB study of ziv-aflibercept plus pembrolizumab in patient
Externí odkaz:
https://doaj.org/article/97b2590c6c9344189d1570b29cf64695
Autor:
Margaret Hallisey, Jenna Dennis, Charlotte Abrecht, Romanos Sklavenitis Pistofidis, Abigail N. Schork, Elizabeth D. Lightbody, Daniel Heilpern-Mallory, Mariano Severgnini, Irene M. Ghobrial, F. Stephen Hodi, Joanna Baginska
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101163- (2022)
Summary: This protocol details a staining technique optimized for immunophenotyping of human bone marrow immune populations using mass cytometry. The protocol accounts for the limitations of working with human bone marrow, such as reduced viability,
Externí odkaz:
https://doaj.org/article/742388b8e446429081c2e354f4ece9c6
Autor:
Mariano Severgnini, Rizwan Haq, Anita Giobbie-Hurder, Scott J Rodig, Patrick A Ott, Evisa Gjini, Ryan J Sullivan, Donald P Lawrence, Matthew Nazzaro, Kathleen L Pfaff, Jacquelyn O Wolff, Elizabeth I Buchbinder
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/209a1d9fbce1433f83f364f311d116e0
Autor:
Mark Awad, Mizuki Nishino, Mariano Severgnini, Biagio Ricciuti, Joao V Alessi, Gonzalo Recondo, Marissa Lawrence, Greg Jones, Tim Forshew, Christine Lydon, Michael Cheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Currently available biomarkers are imperfect in their ability to predict responses to the multiple first-line treatment options available for patients with advanced non-small cell lung cancer (NSCLC). Having an early pharmacodynamic marker
Externí odkaz:
https://doaj.org/article/e6145a4c40b5449aabb45da655be4ef6
Autor:
Mark Awad, Mizuki Nishino, Mariano Severgnini, Biagio Ricciuti, Joao V Alessi, Gonzalo Recondo, Marissa Lawrence, Greg Jones, Tim Forshew, Christine Lydon, Michael Cheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Externí odkaz:
https://doaj.org/article/66aac74d6715476bb41128518795d259