Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mariano Luis Schuman"'
Autor:
Fernando Juan Ingallina, Jorge E. Toblli, Ludmila S. Peres Diaz, Mariano Luis Schuman, Silvia I. García, María Silvina Landa, Maia Aisicovich
Publikováno v:
Journal of cardiac failure. 27(7)
Cardiac thyrotropin-releasing hormone (TRH) is a tripeptide with still unknown functions. We demonstrated that the left ventricle (LV) TRH system is hyperactivated in spontaneously hypertensive rats and its inhibition prevented cardiac hypertrophy an
Autor:
Mariano Luis Schuman, Maria Silvina Landa, Silvia I. García, Maia Aisicovich, Ludmila Soledad Peres Diaz, Carlos José Pirola
Thyrotropin-releasing hormone (TRH) plays several roles as a hormone/neuropeptide. Diencephalic TRH (dTRH) participates in the regulation of blood pressure in diverse animal models, independently of the thyroid status. The present study aimed to eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3ef96195b0a1188d2fb72ba48f8236
http://link.springer.com/10.1007/s13105-020-00765-x
http://link.springer.com/10.1007/s13105-020-00765-x
Autor:
Maia Aisicovich, María Silvina Landa, Silvia I. García, Jorge E. Toblli, Carlos José Pirola, Ludmila S. Peres Diaz, Mariano Luis Schuman
Doxorubicin is an antineoplastic in the anthracycline class widely used for the treatment of several solid tumors and blood cancers. Cardiotoxicity is the major dose-limiting adverse effect of the drug. Chronic and accumulated doxorubicin administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a74f39ed16d42d088c874a5484fd3a4
https://linkinghub.elsevier.com/retrieve/pii/S0024320520310985
https://linkinghub.elsevier.com/retrieve/pii/S0024320520310985
Autor:
María Silvina, Landa, Silvia Inés, García, Mariano Luis, Schuman, Ludmila Soledad, Peres Diaz, Maia, Aisicovich, Carlos José, Pirola
Publikováno v:
Journal of physiology and biochemistry. 76(4)
Thyrotropin-releasing hormone (TRH) plays several roles as a hormone/neuropeptide. Diencephalic TRH (dTRH) participates in the regulation of blood pressure in diverse animal models, independently of the thyroid status. The present study aimed to eval
Autor:
Mariano Luis Schuman, Jorge E. Toblli, Maria Silvina Landa, Silvia I. García, Ludmila Soledad Peres Diaz, Maia Aisicovich
Publikováno v:
Hypertension. 74
Cardiac TRH (cTRH) induces LVH and fibrosis. The adiponectin Leptin induces TRH in CNS. We hypothesized that in obesity, the increase of cTRH induced by hyperleptinemia is responsible for the LVH, mostly attributed to pressure load. We studied obese
Autor:
Maria Silvina Landa, Jorge E. Toblli, Carlos José Pirola, Silvia I. García, Mariano Luis Schuman, Ludmila Soledad Peres Diaz, Maia Aisicovich
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, the TRH increase induces fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a3733ff312b4daf66661c304f44126
https://www.sciencedirect.com/science/article/pii/S002228281830957X
https://www.sciencedirect.com/science/article/pii/S002228281830957X
Autor:
Ludmila S. Peres Diaz, Maria Silvina Landa, Azucena L. Alvarez, Carlos José Pirola, Jorge E. Toblli, Samuel Finkielman, Mariano Luis Schuman, Gabriel Cao, Silvia I. García
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H1667-H1674
Thyrotropin-releasing hormone (TRH) hyperactivity has been observed in the left ventricle of spontaneously hypertensive rats. Its long-term inhibition suppresses the development of hypertrophy, specifically preventing fibrosis. The presence of divers
Autor:
Mariano Luis Schuman, Ludmila S. Peres Diaz, Silvia I. García, Maria Silvina Landa, Maia Aisicovich
Publikováno v:
Hypertension. 68
We have demonstrated TRH hyperactivity in the hypertrophied Left ventricle (LV) of SHR. Its specific inhibition attenuates hypertrophy development in spite of the significant higher pressure observed (Schuman M, Hypertension 2011). LV-TRH over-expres
Deficiency of the antiaging gene Klotho (KL) induces renal damage and hypertension through unknown mechanisms. In this study, we assessed whether KL regulates expression of CYP11B2, a key rate-limiting enzyme in aldosterone synthesis, in adrenal glan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97222e05412c617b1e547a1d691fa3ee
https://europepmc.org/articles/PMC4884100/
https://europepmc.org/articles/PMC4884100/
Autor:
Ludmila S. Peres Diaz, Mariano Luis Schuman, Leonardo Paz, Jorge E. Toblli, Gabriel Cao, Samuel Finkielman, Azucena L. Alvarez, Maria Silvina Landa, Carlos José Pirola, Silvia I. García
Publikováno v:
Hypertension. 57:103-109
Local thyrotropin-releasing hormone (TRH) may be involved in cardiac pathophysiology, but its role in left ventricular hypertrophy (LVH) is still unknown. We studied whether local TRH is involved in LVH of spontaneously hypertensive rats (SHR) by inv