Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Mariano Carrión‐Vázquez"'
Autor:
Rubén Hervás, María del Carmen Fernández-Ramírez, Albert Galera-Prat, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Margarita Menéndez, Douglas V. Laurents, Mariano Carrión-Vázquez
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular interactions. While a
Externí odkaz:
https://doaj.org/article/424f921c44eb4d14bf0ae0e29dc08050
Autor:
María del Carmen Fernández‐Ramírez, Kevin Kan‐Shing Ng, Margarita Menéndez, Douglas V. Laurents, Rubén Hervás, Mariano Carrión‐Vázquez
Publikováno v:
Angewandte Chemie (International ed. in English).
11 pags., 5 figs.
Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well-characterized pathological deposits but its aggregation mechanism is still poorly understood. Using single-molecule
Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well-characterized pathological deposits but its aggregation mechanism is still poorly understood. Using single-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec41f38ddd764f706719f308e941755
https://pubmed.ncbi.nlm.nih.gov/36542681
https://pubmed.ncbi.nlm.nih.gov/36542681
Autor:
Rubén Hervás, Liying Li, Amitabha Majumdar, María Del Carmen Fernández-Ramírez, Jay R Unruh, Brian D Slaughter, Albert Galera-Prat, Elena Santana, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Sergio Casas-Tintó, Margarita Menéndez, Douglas V Laurents, Kausik Si, Mariano Carrión-Vázquez
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002361 (2016)
Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memo
Externí odkaz:
https://doaj.org/article/77f95cb5f9284cf6befdeef4b438bc58
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004541 (2015)
Deposits of misfolded proteins in the human brain are associated with the development of many neurodegenerative diseases. Recent studies show that these proteins have common traits even at the monomer level. Among them, a polyglutamine region that is
Externí odkaz:
https://doaj.org/article/583985de1c92475b888af7d4bbc24d07
Autor:
Mari Suzuki, Douglas V. Laurents, Albert Galera-Prat, Yoshitaka Nagai, Mariano Carrión-Vázquez, Marta Bruix, Margarita Menéndez, Rubén Hervás, María del Carmen Fernández-Ramírez
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
14 pags., 4 figs.
Background: Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular intera
Background: Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920c6b7a6e21dc19b043268434fc4ce3
http://hdl.handle.net/10261/248470
http://hdl.handle.net/10261/248470
Autor:
Margarita Menéndez, Douglas V. Laurents, María del Carmen Fernández-Ramírez, Mariano Carrión-Vázquez, Rubén Hervás
Knowledge on the molecular bases of early amyloid assembly is fundamental to understand its structure-dysfunction relationship during disease progression. Tauopathies, a well-defined set of neurodegenerative disorders that includes Alzheimer’s dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f80f99dc417e0a6482382f9b57def5
https://doi.org/10.1101/2020.06.18.158923
https://doi.org/10.1101/2020.06.18.158923
Autor:
Mariano Carrión-Vázquez, Douglas V. Laurents, Paula López-García, Daniel Ramírez de Mingo, Rubén Hervás
The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), is an RNA-binding protein which in its soluble state is localized in membraneless neuronal RNA granules keeping target mRNAs in a repressed state. The stimulus-dependent aggregation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e264ac3da62a28e034511d65d399acf2
https://doi.org/10.1101/2020.06.02.129783
https://doi.org/10.1101/2020.06.02.129783
Autor:
Mariano Carrión-Vázquez, David Pantoja-Uceda, Daniel Ramírez de Mingo, Douglas V. Laurents, Rubén Hervás
Amyloids play key pathological roles in a score of neurodegenerative diseases, but they are also essential to several physiological processes. Perhaps the most fascinating functional amyloid is formed by the Cytoplasmic Polyadenylation Element Bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cabc61122fbd67078ee01fd9243f9d7
https://doi.org/10.1101/2020.05.12.091587
https://doi.org/10.1101/2020.05.12.091587
An anti-amyloidogenic treatment to specifically block the consolidation of traumatic events in mouse
Autor:
Mariano Carrión-Vázquez, Daniel Ramírez de Mingo, Anna Pallé López, Helena Akiko Popiel, Paula López-García, José Luis Trejo, Kerry R. McGreevy, Yoshitaka Nagai, Andrea Santi
Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by the exposure to a traumatic event that manifests with anguish, intrusive memories and negative mood changes. So far, there is no efficient treatment for PTSD other than sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45273b2d1a5613ed553dc187277b239e
Autor:
Rubén Hervás, Javier Oroz, Albert Galera-Prat, Oscar Goñi, Alejandro Valbuena, Andrés M Vera, Angel Gómez-Sicilia, Fernando Losada-Urzáiz, Vladimir N Uversky, Margarita Menéndez, Douglas V Laurents, Marta Bruix, Mariano Carrión-Vázquez
Publikováno v:
PLoS Biology, Vol 10, Iss 5, p e1001335 (2012)
Amyloidogenic neurodegenerative diseases are incurable conditions with high social impact that are typically caused by specific, largely disordered proteins. However, the underlying molecular mechanism remains elusive to established techniques. A fav
Externí odkaz:
https://doaj.org/article/ace39d0bb3a74abdb135fcb523029e9a