Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Marianne de Villiers"'
Autor:
Tshifhiwa Muthelo, Vhahangwele Mulaudzi, Munei Netshishivhe, Tendamudzimu Harmfree Dongola, Michelle Kok, Stanley Makumire, Marianne de Villiers, Adélle Burger, Tawanda Zininga, Addmore Shonhai
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Plasmodium falciparum Hsp70-1 (PfHsp70-1; PF3D7_0818900) and PfHsp90 (PF3D7_0708400) are essential cytosol localized chaperones of the malaria parasite. The two chaperones form a functional complex via the adaptor protein, Hsp90-Hsp70 organizing prot
Externí odkaz:
https://doaj.org/article/e9b128e2dddd4c5da14c4ad1e0000847
Publikováno v:
Cells, Vol 10, Iss 11, p 2849 (2021)
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public health threat. The development of antimalarial drug resistance is reversing the gains made in attempts to control the disease. The parasite leads a comp
Externí odkaz:
https://doaj.org/article/89dad5f8e1934790a56c245e40e2c2b4
Autor:
Tshifhiwa, Muthelo, Vhahangwele, Mulaudzi, Munei, Netshishivhe, Tendamudzimu Harmfree, Dongola, Michelle, Kok, Stanley, Makumire, Marianne, de Villiers, Adélle, Burger, Tawanda, Zininga, Addmore, Shonhai
Publikováno v:
Frontiers in molecular biosciences. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5066a285b16698d64025f233e0ae315
https://pubmed.ncbi.nlm.nih.gov/36177352
https://pubmed.ncbi.nlm.nih.gov/36177352
Autor:
Darvina Mahesh, Christina Spry, Kevin J. Saliba, Leanne Barnard, Marianne de Villiers, Andrew Powell, Erick T. Tjhin, Michélle Kok, Erick Strauss
Publikováno v:
ACS Infectious Diseases. 6:1844-1854
Pantothenamides (PanAms) are potent antiplasmodials with low human toxicity currently being investigated as antimalarials with a novel mode of action. These structural analogues of pantothenate, th...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781c912733e7478732d0fa86d79af39a
https://doi.org/10.1021/acsinfecdis.0c00075
https://doi.org/10.1021/acsinfecdis.0c00075
Publikováno v:
Cells, Vol 10, Iss 2849, p 2849 (2021)
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public health threat. The development of antimalarial drug resistance is reversing the gains made in attempts to control the disease. The parasite leads a comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ae03cd7e8b5afbf9dc092eeb085791
https://www.mdpi.com/2073-4409/10/11/2849
https://www.mdpi.com/2073-4409/10/11/2849
Publikováno v:
Cells
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public health threat. The development of antimalarial drug resistance is reversing the gains made in attempts to control the disease. The parasite leads a comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85ccf9bfb2ac4f4b5c956acdaada9fa5
https://pubmed.ncbi.nlm.nih.gov/34831072
https://pubmed.ncbi.nlm.nih.gov/34831072
Autor:
Christina, Spry, Leanne, Barnard, Michélle, Kok, Andrew K, Powell, Darvina, Mahesh, Erick T, Tjhin, Kevin J, Saliba, Erick, Strauss, Marianne, de Villiers
Publikováno v:
ACS infectious diseases. 6(7)
Pantothenamides (PanAms) are potent antiplasmodials with low human toxicity currently being investigated as antimalarials with a novel mode of action. These structural analogues of pantothenate, the vitamin precursor of the essential cofactor coenzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71f1d8f8ce7989cfc76ddffd4ebaa8b4
https://pubmed.ncbi.nlm.nih.gov/32375471
https://pubmed.ncbi.nlm.nih.gov/32375471
Autor:
Kevin J. Saliba, Gordon Wells, Christina Spry, Erick Strauss, Marianne de Villiers, Leanne Barnard, Cristiano J. Macuamule
Publikováno v:
ACS Infectious Diseases. 3:527-541
N-Substituted pantothenamides (PanAms) are pantothenate analogues with up to nanomolar potency against blood-stage Plasmodium falciparum (the most virulent species responsible for malaria). Although these compounds are known to target coenzyme A (CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dbb639a30b792acd588e9adbddff69
https://doi.org/10.1021/acsinfecdis.7b00024
https://doi.org/10.1021/acsinfecdis.7b00024
Autor:
Erick Strauss, Marianne de Villiers
Publikováno v:
The Biochemist. 37:19-23
Humankind's struggle to find cures for infectious diseases is as old as humanity itself. During the last century, we have probably made the greatest advance in our battle against these diseases: the discovery of antibiotics. Importantly, the first an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8974b0545327cd653ea60a67e4f85535
https://doi.org/10.1042/bio03701019
https://doi.org/10.1042/bio03701019
Autor:
Emanuela Rizzetto, Marianne de Villiers, Alen Čusak, Marianne van der Zwaag, Jerca Pahor, Susan J. Hayflick, Balaji Srinivasan, Ody C. M. Sibon, Jeffrey Hamada, Nicola A. Grzeschik, Gregor Kosec, Cristina Colombelli, Valeria Tiranti, Pieter G. Tepper, Suh Young Jeong, Clara H Harrs, Randall L. Woltjer, Liza L. Lahaye, Rachel Fox, Theo de Boer, Ivano Di Meo, Branko Jenko
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, 7(1):11260. Nature Publishing Group
Scientific Reports
Scientific Reports, 7(1):11260. Nature Publishing Group
Scientific Reports
Coenzyme A is an essential metabolite known for its central role in over one hundred cellular metabolic reactions. In cells, Coenzyme A is synthesized de novo in five enzymatic steps with vitamin B5 as the starting metabolite, phosphorylated by panto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c812209d27519416763383219002e
https://doi.org/10.1038/s41598-017-11564-8
https://doi.org/10.1038/s41598-017-11564-8