Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Marianne Z. Metz"'
Autor:
Revathiswari Tirughana, Marianne Z. Metz, Zhongqi Li, Christine Hall, David Hsu, Jim Beltzer, Alexander J. Annala, Diana Oganesyan, Margarita Gutova, Karen S. Aboody
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 48-56 (2018)
Cell-based therapies hold great promise for a myriad of clinical applications. However, as these therapies move from phase I to phase II and III trials, there is a need to improve scale-up of adherent cells for the production of larger good manufactu
Externí odkaz:
https://doaj.org/article/c126929903314962a31a0427d61eb6d7
Autor:
Karen S. Aboody, Seung U. Kim, Carlotta A. Glackin, Margarita Gutova, Marianne Z. Metz, Elizabeth Garcia, Joseph Najbauer, Donghong Zhao
Supplementary Figure S1 from Neural Stem Cell Tropism to Glioma: Critical Role of Tumor Hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a536df81e0b0e060500ea302bcc079
https://doi.org/10.1158/1541-7786.22517203
https://doi.org/10.1158/1541-7786.22517203
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Purpose: Human neural stem cells (NSC) are inherently tumor tropic, making them attractive drug delivery vehicles. Toward this goal, we retrovirally transduced an immortalized, clonal NSC line to stably express cytosine deaminase (HB1.F3.CD.C21; CD-N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ab89cbd3f2f7dadf975717cb752040
https://doi.org/10.1158/1078-0432.c.6525081
https://doi.org/10.1158/1078-0432.c.6525081
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Supplementary Methods from Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3e80f6c51edebd28bad02354409adc
https://doi.org/10.1158/1078-0432.22462332
https://doi.org/10.1158/1078-0432.22462332
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Supplementary Table 1: A standard 3 + 3 dose escalation design (19) was used to investigate 3 dose levels of CD-NSCs and 5-FC. Supplementary Table 2: Characteristics of the 15 patients who received study treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd7ea59bc2c05c37981fd6fa58e9c64
https://doi.org/10.1158/1078-0432.22462329.v1
https://doi.org/10.1158/1078-0432.22462329.v1
Autor:
Behnam Badie, Revathiswari Tirughana, Marianne Z. Metz, Karen S. Aboody, M. Suzette Blanchard, Julie A. Ressler, Massimo D'Apuzzo, Julie Kilpatrick, Shu Mi, Vivi Tran, Timothy W. Synold, Jana Portnow
Publikováno v:
Cancer Gene Therapy. 28:294-306
Neural stem cells (NSCs) are tumor tropic and can be genetically modified to produce anti-cancer therapies locally in the brain. In a prior first-in-human study we demonstrated that a single dose of intracerebrally administered allogeneic NSCs, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3cf0573d7d3cefebf0fad6d813fc0
https://doi.org/10.1038/s41417-020-00219-y
https://doi.org/10.1038/s41417-020-00219-y
Autor:
Christine Hall, Alexander J. Annala, Karen S. Aboody, James P. Beltzer, Margarita Gutova, Zhongqi Li, Revathiswari Tirughana, Diana Oganesyan, David Hsu, Marianne Z. Metz
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 48-56 (2018)
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 48-56 (2018)
Cell-based therapies hold great promise for a myriad of clinical applications. However, as these therapies move from phase I to phase II and III trials, there is a need to improve scale-up of adherent cells for the production of larger good manufactu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0e93ece03b882ebaf1381e365b193c
http://europepmc.org/articles/PMC6037686
http://europepmc.org/articles/PMC6037686
Autor:
Margarita Gutova, Joseph Najbauer, Anna Gevorgyan, Marianne Z Metz, Yehua Weng, Chu-Chih Shih, Karen S Aboody
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e243 (2007)
BACKGROUND: The urokinase plasminogen activator (uPA) and its receptor (uPAR/CD87) are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR
Externí odkaz:
https://doaj.org/article/1e6057e471ff44b693536ad3a45dbd3f
Autor:
Karen S Aboody, Rebecca A Bush, Elizabeth Garcia, Marianne Z Metz, Joseph Najbauer, Kristine A Justus, Doris A Phelps, Joanna S Remack, Karina Jin Yoon, Shanna Gillespie, Seung U Kim, Carlotta A Glackin, Philip M Potter, Mary K Danks
Publikováno v:
PLoS ONE, Vol 1, p e23 (2006)
Patients diagnosed with metastatic cancer have almost uniformly poor prognoses. The treatments available for patients with disseminated disease are usually not curative and have side effects that limit the therapy that can be given. A treatment that
Externí odkaz:
https://doaj.org/article/fbdc182300744ae18ba3c46343dfa818
Autor:
Michael E. Barish, Siranush Argalian Herculian, Lucy Ghoda, Marianne Z. Metz, Leanne Goldstein, Christine E. Brown, Jennifer Gutierrez, Russell Rockne, Kelsey A. Herrmann, Alexander J. Annala, Karen S. Aboody, Margarita Gutova, Rex Moats, Revathiswari Tirughana, Soraya Aramburo, Yang Tang
Publikováno v:
Stem Cells Translational Medicine
Engineered neural stem cells (NSCs) intrinsically migrating to brain tumors offer a promising mechanism for local therapeutic delivery. However, difficulties in quantitative assessments of NSC migration and in estimates of tumor coverage by diffusibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3dd973e85818adcccb12d0adc7f3c1
https://doi.org/10.1002/sctm.16-0397
https://doi.org/10.1002/sctm.16-0397