Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Marianne Z Metz"'
Autor:
Joseph Najbauer, Peter C Huszthy, Michael E Barish, Elizabeth Garcia, Marianne Z Metz, Sarah M Myers, Margarita Gutova, Richard T Frank, Hrvoje Miletic, Stephen E Kendall, Carlotta A Glackin, Rolf Bjerkvig, Karen S Aboody
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35150 (2012)
BACKGROUND: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular composition of the tumor
Externí odkaz:
https://doaj.org/article/3189767300cc4139a0a12b54b1996e19
Autor:
Mya S Thu, Joseph Najbauer, Stephen E Kendall, Ira Harutyunyan, Nicole Sangalang, Margarita Gutova, Marianne Z Metz, Elizabeth Garcia, Richard T Frank, Seung U Kim, Rex A Moats, Karen S Aboody
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7218 (2009)
Treatment strategies for the highly invasive brain tumor, glioblastoma multiforme, require that cells which have invaded into the surrounding brain be specifically targeted. The inherent tumor-tropism of neural stem cells (NSCs) to primary and invasi
Externí odkaz:
https://doaj.org/article/6e9c6530b27f450e81d5afb3fe211ad2
Autor:
Richard T Frank, Marissa Edmiston, Stephen E Kendall, Joseph Najbauer, Chia-Wei Cheung, Thewodros Kassa, Marianne Z Metz, Seung U Kim, Carlotta A Glackin, Anna M Wu, Paul J Yazaki, Karen S Aboody
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8314 (2009)
BACKGROUND: Recombinant monoclonal antibodies have emerged as important tools for cancer therapy. Despite the promise shown by antibody-based therapies, the large molecular size of antibodies limits their ability to efficiently penetrate solid tumors
Externí odkaz:
https://doaj.org/article/3159f93b5aa04d759d7b2560ec324484
Autor:
Margarita Gutova, Joseph Najbauer, Anna Gevorgyan, Marianne Z Metz, Yehua Weng, Chu-Chih Shih, Karen S Aboody
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e243 (2007)
BACKGROUND: The urokinase plasminogen activator (uPA) and its receptor (uPAR/CD87) are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR
Externí odkaz:
https://doaj.org/article/1e6057e471ff44b693536ad3a45dbd3f
Autor:
Karen S Aboody, Rebecca A Bush, Elizabeth Garcia, Marianne Z Metz, Joseph Najbauer, Kristine A Justus, Doris A Phelps, Joanna S Remack, Karina Jin Yoon, Shanna Gillespie, Seung U Kim, Carlotta A Glackin, Philip M Potter, Mary K Danks
Publikováno v:
PLoS ONE, Vol 1, p e23 (2006)
Patients diagnosed with metastatic cancer have almost uniformly poor prognoses. The treatments available for patients with disseminated disease are usually not curative and have side effects that limit the therapy that can be given. A treatment that
Externí odkaz:
https://doaj.org/article/fbdc182300744ae18ba3c46343dfa818
Autor:
Karen S. Aboody, Seung U. Kim, Carlotta A. Glackin, Margarita Gutova, Marianne Z. Metz, Elizabeth Garcia, Joseph Najbauer, Donghong Zhao
Supplementary Figure S1 from Neural Stem Cell Tropism to Glioma: Critical Role of Tumor Hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a536df81e0b0e060500ea302bcc079
https://doi.org/10.1158/1541-7786.22517203
https://doi.org/10.1158/1541-7786.22517203
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Purpose: Human neural stem cells (NSC) are inherently tumor tropic, making them attractive drug delivery vehicles. Toward this goal, we retrovirally transduced an immortalized, clonal NSC line to stably express cytosine deaminase (HB1.F3.CD.C21; CD-N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ab89cbd3f2f7dadf975717cb752040
https://doi.org/10.1158/1078-0432.c.6525081
https://doi.org/10.1158/1078-0432.c.6525081
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Supplementary Methods from Neural Stem Cell–Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3e80f6c51edebd28bad02354409adc
https://doi.org/10.1158/1078-0432.22462332
https://doi.org/10.1158/1078-0432.22462332
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Supplementary Table 1: A standard 3 + 3 dose escalation design (19) was used to investigate 3 dose levels of CD-NSCs and 5-FC. Supplementary Table 2: Characteristics of the 15 patients who received study treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd7ea59bc2c05c37981fd6fa58e9c64
https://doi.org/10.1158/1078-0432.22462329.v1
https://doi.org/10.1158/1078-0432.22462329.v1
Autor:
Behnam Badie, Revathiswari Tirughana, Marianne Z. Metz, Karen S. Aboody, M. Suzette Blanchard, Julie A. Ressler, Massimo D'Apuzzo, Julie Kilpatrick, Shu Mi, Vivi Tran, Timothy W. Synold, Jana Portnow
Publikováno v:
Cancer Gene Therapy. 28:294-306
Neural stem cells (NSCs) are tumor tropic and can be genetically modified to produce anti-cancer therapies locally in the brain. In a prior first-in-human study we demonstrated that a single dose of intracerebrally administered allogeneic NSCs, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3cf0573d7d3cefebf0fad6d813fc0
https://doi.org/10.1038/s41417-020-00219-y
https://doi.org/10.1038/s41417-020-00219-y