Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Marianne V Chew"'
Autor:
Amanda J Lee, Emily Feng, Marianne V Chew, Elizabeth Balint, Sophie M Poznanski, Elizabeth Giles, Ali Zhang, Art Marzok, Spencer D Revill, Fatemeh Vahedi, Anisha Dubey, Ehab Ayaub, Rodrigo Jimenez-Saiz, Joshua J C McGrath, Tyrah M Ritchie, Manel Jordana, Danny D Jonigk, Maximilian Ackermann, Kjetil Ask, Matthew Miller, Carl D Richards, Ali A Ashkar
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010471 (2022)
The ability to treat severe viral infections is limited by our understanding of the mechanisms behind virus-induced immunopathology. While the role of type I interferons (IFNs) in early control of viral replication is clear, less is known about how I
Externí odkaz:
https://doaj.org/article/bac7c41243064cfda47eb006b0f0cc7c
Autor:
Sophie M Poznanski, Tyrah M Ritchie, Isabella Y Fan, Abdullah El-Sayes, Ana L Portillo, Ronny Ben-Avi, Eduardo A Rojas, Marianne V Chew, Yaron Shargall, Ali A Ashkar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Lung cancer remains the leading cause of cancer death worldwide despite the significant progress made by immune checkpoint inhibitors, including programmed death receptor-1 (PD1)/PD ligand 1 (PDL1)-blockade therapy. PD1/PDL1−blockade has achieved u
Externí odkaz:
https://doaj.org/article/5c2b468f76e44401addc26aa4764c247
IFN- signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity
Autor:
Yalda Karimi, Elizabeth C Giles, Fatemeh Vahedi, Marianne V Chew, Tina Nham, Dessi Loukov, Amanda J Lee, Dawn ME Bowdish, Ali A Ashkar
Publikováno v:
Innate Immunity, Vol 26 (2020)
Type I IFN holds a critical role in host defence, providing protection against pathogenic organisms through coordinating a pro-inflammatory response. Type I IFN provides additional protection through mitigating this inflammatory response, preventing
Externí odkaz:
https://doaj.org/article/010956b6f2b54f88b1769ebf27c59106
Autor:
Nicole G Barra, Rengasamy Palanivel, Emmanuel Denou, Marianne V Chew, Amy Gillgrass, Tina D Walker, Josh Kong, Carl D Richards, Manel Jordana, Stephen M Collins, Bernardo L Trigatti, Alison C Holloway, Sandeep Raha, Gregory R Steinberg, Ali A Ashkar
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114799 (2014)
Interleukin-15 (IL-15) is an immunomodulatory cytokine that affects body mass regulation independent of lymphocytes; however, the underlying mechanism(s) involved remains unknown. In an effort to investigate these mechanisms, we performed metabolic c
Externí odkaz:
https://doaj.org/article/3b4ba187aaf348a0922604e1373b3f92
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39553 (2012)
Obesity is a chronic inflammatory condition characterized by activation and infiltration of proinflammatory immune cells and a dysregulated production of proinflammatory cytokines. While known as a key regulator of immune natural killer (NK) cell fun
Externí odkaz:
https://doaj.org/article/5a13da0a3b7f4d1bb31f95a0418ab799
Autor:
Mohamed F Abdul-Careem, Amanda J Lee, Elishka A Pek, Navkiran Gill, Amy E Gillgrass, Marianne V Chew, Sarah Reid, Ali A Ashkar
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32821 (2012)
NK cells are known as innate immune cells that lack immunological memory. Recently, it has been shown that NK cells remember encounters with chemical haptens that induce contact hypersensitivity and cytomegalovirus infection. Here, we show the existe
Externí odkaz:
https://doaj.org/article/9de33a6e3fe247e1b5efa8089fdf0e0f
Autor:
Ali A. Ashkar, Hal W. Hirte, Dean A. Lee, Jonathan L. Bramson, Martin Butcher, Isabella Y. Fan, Joanne A. Hammill, Amanda J. Lee, Marianne V. Chew, Tina Nham, Sophie M. Poznanski
Natural killer (NK) cells are useful for cancer immunotherapy and have proven clinically effective against hematologic malignancies. However, immunotherapies for poor prognosis solid malignancies, including ovarian cancer, have not been as successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fde7221724f3dcb346f3da713a0077
https://doi.org/10.1158/2326-6066.c.6548206.v1
https://doi.org/10.1158/2326-6066.c.6548206.v1
Autor:
Ali A. Ashkar, Hal W. Hirte, Dean A. Lee, Jonathan L. Bramson, Martin Butcher, Isabella Y. Fan, Joanne A. Hammill, Amanda J. Lee, Marianne V. Chew, Tina Nham, Sophie M. Poznanski
Expression of NK cell activation and inhibitory ligands on resistant primary ovarian cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5246be899e0432b7c626a781070dc853
https://doi.org/10.1158/2326-6066.22536676.v1
https://doi.org/10.1158/2326-6066.22536676.v1
Autor:
Jonathan L. Bramson, Marianne V. Chew, Jeremy A. Hirota, Niamh J. Cashell, Mira M. Shenouda, Ali A. Ashkar, Sophie M. Poznanski, Richard Hogg, Tyrah M. Ritchie, Quynh T. Cao, Joanne A. Hammill, Sukhbinder Dhesy-Thind, Eduardo A. Rojas, Ana L. Portillo
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102619-(2021)
iScience
iScience
Summary Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against hematologic malignancies, severe off-tumor effects have constrained their use against solid tumors. Recently, CAR-engineered natural killer (NK) cells have emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc2c60ee64fecd6302b4282435a8c17
http://www.sciencedirect.com/science/article/pii/S2589004221005873
http://www.sciencedirect.com/science/article/pii/S2589004221005873
Autor:
Elizabeth C. Giles, Fatemeh Vahedi, Yalda Karimi, Tina Nham, Dawn M. E. Bowdish, Ali A. Ashkar, Amanda J. Lee, Marianne V. Chew, Dessi Loukov
Publikováno v:
Innate Immunity
Innate Immunity, Vol 26 (2020)
Innate Immunity, Vol 26 (2020)
Type I IFN holds a critical role in host defence, providing protection against pathogenic organisms through coordinating a pro-inflammatory response. Type I IFN provides additional protection through mitigating this inflammatory response, preventing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0509c18362458465158ba24ea54170d6
http://europepmc.org/articles/PMC7144030
http://europepmc.org/articles/PMC7144030