Expanded murine regulatory T cells: Analysis of phenotype and function in contact hypersensitivity reactions

Autor: Leah Pretsch, Marianne Thome, Karsten Mahnke, Alexander Enk, Sabine Ring

Publikováno v: Journal of Immunological Methods. 326:10-21

Regulatory T cells (Treg) exert suppressive functions in the periphery of the body for the maintenance of tolerance. The functional analysis of Treg is hampered by the fact that only small numbers (5%-10% among the CD4(+) T cells) of Treg exist in pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152c1dadfccb17bad11856278e5b1f11
https://doi.org/10.1016/j.jim.2007.06.007

BRAF mutations distinguish anorectal from cutaneous melanoma at the molecular level

Autor: Nikolaus Gassler, Herwart F. Otto, Marianne Thome, Burkhard Helmke, Wolfgang Wahl, Annemarie Poustka, Stefan Lyer, Jan Mollenhauer, Martin Deichmann, Axel Benner, Christel Herold-Mende

Publikováno v: Helmke, B M, Mollenhauer, J, Herold-Mende, C, Benner, A, Thome, M, Gassler, N, Wahl, W, Lyer, S, Poustka, A, Otto, H F & Deichmann, M 2004, ' BRAF mutations distinguish anorectal from cutaneous melanoma at the molecular level. ', Gastroenterology, vol. 127, no. 6, pp. 1815-20 .

Udgivelsesdato: 2004-Dec BACKGROUND & AIMS: Anorectal melanoma (AM) is a rare but highly malignant tumor, displaying histologic and immunohistochemical features very similar to cutaneous melanoma (CM). Because BRAF mutations were recently identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e693c1c1f81d749bde70df39c15f03f
https://doi.org/10.1053/j.gastro.2004.08.051

Analysis of Losses of Heterozygosity of the Candidate Tumour Suppressor Gene DMBT1 in Melanoma Resection Specimens

Autor: Marianne Thome, Helmut Näher, Martin Deichmann, J Mollenhauer, Wolfgang Hartschuh, A Poustka, Burkhard Helmke

Publikováno v: Oncology. 63:166-172

Deleted in malignant brain tumours 1 (DMBT1), a candidate tumour suppressor gene located on chromosome 10q25.3-q26.1, has recently been identified and found to be deleted in several different types of human tumours. In melanomas, the chromosomal regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d7ac6aa0bc9c8c6c6fcae5ce0f6a34c
https://doi.org/10.1159/000063802

The oncogenic B-raf V599E mutation occurs more frequently in melanomas at sun-protected body sites

Autor: Judith Hassanzadeh, Marianne Thome, Martin Deichmann, Kirsten Wüst, Dieter Krahl, Burkhard Helmke

Publikováno v: International journal of oncology. 29(1)

Downstream of Ras, the serine/threonine kinase, B-raf, has recently been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of the oncogenic V599E transition. As the risk of melanoma is e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29532b3b8da1d2cf00c4dce852bd696d
https://pubmed.ncbi.nlm.nih.gov/16773193

Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases

Autor: Axel Benner, Birgit Kahle, Christian Kleist, Myriam Polychronidis, Martin Deichmann, Burkhard Helmke, Marianne Thome

Publikováno v: International journal of oncology. 25(2)

Seeking to identify melanoma-associated genes by comparing gene expression in uncultured primary melanoma specimens with those in nevi, from which melanomas often are known to arise, we applied subtractive suppression hybridization. Generating a subt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12044fe3edb56d069867ae7a75fb3d91
https://pubmed.ncbi.nlm.nih.gov/15254721