Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Marianne Rooman"'
Autor:
Matsvei Tsishyn, Gabriel Cia, Pauline Hermans, Jean Kwasigroch, Marianne Rooman, Fabrizio Pucci
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-10 (2024)
Abstract Systematically predicting the effects of mutations on protein fitness is essential for the understanding of genetic diseases. Indeed, predictions complement experimental efforts in analyzing how variants lead to dysfunctional proteins that i
Externí odkaz:
https://doaj.org/article/4857b80b30d148b5b93c8d5dcbd7d1b8
Autor:
Yaqing Yang, Zhonghui Wei, Gabriel Cia, Xixi Song, Fabrizio Pucci, Marianne Rooman, Fuzhong Xue, Qingzhen Hou
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Major histocompatibility complex Class II (MHCII) proteins initiate and regulate immune responses by presentation of antigenic peptides to CD4+ T-cells and self-restriction. The interactions between MHCII and peptides determine the specificity of the
Externí odkaz:
https://doaj.org/article/b3e1da7d4a5945d2b7ba5241f41096db
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 434-442 (2022)
Over the past decade, metagenomic sequencing approaches have been providing an ever-increasing amount of protein sequence data at an astonishing rate. These constitute an invaluable source of information which has been exploited in various research f
Externí odkaz:
https://doaj.org/article/6700e180948347679c2002a61af2da12
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed this issue through the f
Externí odkaz:
https://doaj.org/article/4552f96fda1a42a38d805ce25d70a9c1
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Understanding the role of stability strengths and weaknesses in proteins is a key objective for rationalizing their dynamical and functional properties such as conformational changes, catalytic activity, and protein-protein and protein-ligand interac
Externí odkaz:
https://doaj.org/article/cc33f4ed640446bd910d23e1e1275813
Autor:
Fabrizio Pucci, Marianne Rooman
Publikováno v:
BMC Genomics, Vol 20, Iss S8, Pp 1-11 (2019)
Abstract Background It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progres
Externí odkaz:
https://doaj.org/article/aec67300d6f74573a6fb5395e2c81f7a
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The solubility of globular proteins is a basic biophysical property that is usually a prerequisite for their functioning. In this study, we probed the solubility of globular proteins with the help of the statistical potential formalism, in v
Externí odkaz:
https://doaj.org/article/3eac4e9330274cf091576e3224b564c9
Autor:
Fabrizio Pucci, Filippo Annoni, Robson Augusto Souza dos Santos, Fabio Silvio Taccone, Marianne Rooman
Publikováno v:
Cells, Vol 10, Iss 10, p 2755 (2021)
The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological processes, among which inflammation and blood pressure regulation. One of its key components, the angiotensin-converting enzyme 2, has been identified as the en
Externí odkaz:
https://doaj.org/article/3af76b9892334c41bffd949854cd41ef
Autor:
Fabrizio Pucci, Marianne Rooman
Publikováno v:
Viruses, Vol 13, Iss 5, p 935 (2021)
The understanding of the molecular mechanisms driving the fitness of the SARS-CoV-2 virus and its mutational evolution is still a critical issue. We built a simplified computational model, called SpikePro, to predict the SARS-CoV-2 fitness from the a
Externí odkaz:
https://doaj.org/article/53a7a4838fc94f0c8d00276cb1d01663
Publikováno v:
Viruses, Vol 12, Iss 12, p 1367 (2020)
SARS-CoV-2 infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundam
Externí odkaz:
https://doaj.org/article/a04ae6538a054b9f96e6843cc4a99f04