Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Marianne R. Spalinger"'
Autor:
Marlene Schwarzfischer, Tano S. Ruoss, Anna Niechcial, Sung Sik Lee, Marcin Wawrzyniak, Andrea Laimbacher, Kirstin Atrott, Roberto Manzini, Marijn Wilmink, Luise Linzmeier, Yasser Morsy, Silvia Lang, Gerhard Rogler, Ralf Kaegi, Michael Scharl, Marianne R. Spalinger
Publikováno v:
Nanomaterials, Vol 14, Iss 16, p 1350 (2024)
Background: The increasing presence of plastics in the human diet is raising public concern about the potential risks posed by nanoplastic (NP) particles, which can emerge from the degradation of plastic debris. NP ingestion poses particular risks to
Externí odkaz:
https://doaj.org/article/7a341b7c98c64d56b31dd3f8a2d9dd1c
Autor:
Marianna Carone, Marianne R. Spalinger, Robert A. Gaultney, Raffaele Mezzenga, Kristýna Hlavačková, Aart Mookhoek, Philippe Krebs, Gerhard Rogler, Paola Luciani, Simone Aleandri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ulcerative colitis is a chronic inflammatory bowel disease that strongly affects patient quality of life. Side effects of current therapies necessitate new treatment strategies that maximise the drug concentration at the site of inflammation
Externí odkaz:
https://doaj.org/article/2d75cfd0314f4f04b7c907fb1bf398fb
Autor:
Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 39-62 (2023)
Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage comm
Externí odkaz:
https://doaj.org/article/6312182efc1f47dca7056b2a59fb791d
Autor:
Janine Häfliger, Marlene Schwarzfischer, Kirstin Atrott, Claudia Stanzel, Yasser Morsy, Marcin Wawrzyniak, Silvia Lang, Tomas Valenta, Konrad Basler, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 717-739 (2023)
Background & Aims: Glycoprotein (GP)96 is an endoplasmic reticulum–resident master chaperone for cell surface receptors including the Wnt co-receptors low-density lipoprotein-receptor–related protein 5/6. Intestinal epithelial cell (IEC)-specific
Externí odkaz:
https://doaj.org/article/9a20e5b0ea1a40e19da95551ede99806
Autor:
Marianne R. Spalinger, Stephanie Kasper, Claudia Gottier, Silvia Lang, Kirstin Atrott, Stephan R. Vavricka, Sylvie Scharl, Petrus M. Gutte, Markus G. Grütter, Hans-Dietmar Beer, Emmanuel Contassot, Andrew C. Chan, Xuezhi Dai, David J. Rawlings, Florian Mair, Burkhard Becher, Werner Falk, Michael Fried, Gerhard Rogler, Michael Scharl
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/1a86c5abc8534e9cbf373703d4260d85
Autor:
Marianne R. Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli’sa Crawford, Alina N. Santos, Pritha Chatterjee, Jiang Li, Meera G. Nair, Declan F. McCole
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Macrophages intimately interact with intestinal epithelial cells, but the consequences of defective macrophage–epithelial cell interactions for protection against enteric pathogens are poorly understood. Here, we show that in mice with a deletion i
Externí odkaz:
https://doaj.org/article/4a7e0dcb82a94f50a7e8005e4bb6f94c
Autor:
Cheryl de Vallière, Katharina Bäbler, Philipp Busenhart, Marlene Schwarzfischer, Chiaki Maeyashiki, Cordelia Schuler, Kirstin Atrott, Silvia Lang, Marianne R. Spalinger, Michael Scharl, Pedro A. Ruiz-Castro, Martin Hausmann, Gerhard Rogler
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Background and Aims: Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory diseases, and inflammatory bowel disease (IBD). Several recent studies reported a link between IBD
Externí odkaz:
https://doaj.org/article/9b79683e8b92491caaad15387242bfbd
Autor:
Ali Shawki, Rocio Ramirez, Marianne R. Spalinger, Paul M. Ruegger, Anica Sayoc-Becerra, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, Jonathan D. Mitchell, John C. Macbeth, Casey M. Gries, Michel L. Tremblay, Ansel Hsiao, James Borneman, Declan F. McCole
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1547-1566 (2020)
Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene incr
Externí odkaz:
https://doaj.org/article/20562da928e4413393bb29a2492d7c9e
Autor:
Tina Raselli, Tom Hearn, Annika Wyss, Kirstin Atrott, Alain Peter, Isabelle Frey-Wagner, Marianne R. Spalinger, Ewerton M. Maggio, Andreas W. Sailer, Johannes Schmitt, Philipp Schreiner, Anja Moncsek, Joachim Mertens, Michael Scharl, William J. Griffiths, Marco Bueter, Andreas Geier, Gerhard Rogler, Yuqin Wang, Benjamin Misselwitz
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 7, Pp 1270-1283 (2019)
Nonalcoholic steatohepatitis (NASH), a primary cause of liver disease, leads to complications such as fibrosis, cirrhosis, and carcinoma, but the pathophysiology of NASH is incompletely understood. Epstein-Barr virus-induced G protein-coupled recepto
Externí odkaz:
https://doaj.org/article/71adacb59edc492490ef23699d5a4403
Autor:
Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Philipp Busenhart, Claudia Gottier, Dunja Mrdjen, Juliana Komuczki, Marcin Wawrzyniak, Silvia Lang, Kirstin Atrott, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Protein tyrosine phosphatase non-receptor type 2 (PTPN2) plays a pivotal role in immune homeostasis and has been associated with human autoimmune and chronic inflammatory diseases. Though PTPN2 is well-characterized in lymphocytes, little is known ab
Externí odkaz:
https://doaj.org/article/cbebd70e616b461caf11840570e37a9a