Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marianne R. Spada"'
Publikováno v:
Journal of Heterocyclic Chemistry. 26:1851-1857
The utility of certain 5-alkynyloxy-, 5-alkynylthio, and 5-alkynylsulfinyl-pyrimidines as precursors of 7-substituted furo[3,2-d]- and thieno[3,2-d]pyrimidines has been examined. When treated with sodium methoxide in warm methyl sulfoxide, 1,3-dimeth
Publikováno v:
Nucleosides and Nucleotides. 16:1983-1998
Two approaches to the synthesis of the title compounds are described. In the first route, a reactive 5-oxo-6-methylene pyrimidine intermediate that is generated by treating the bis-acetylated or bis-benzoylated nucleosides 10 and 11 with sodium hydro
Publikováno v:
ChemInform. 29
Autor:
Akira Matsuda, Linda A. Jelicks, Brian A. Otter, Marianne R. Spada, Robyn S. Klein, Yuichi Yoshimura, Shirish A. Patil
Publikováno v:
Nucleosides and Nucleotides. 11:615-635
The 5-oxo-6-methylene-pyrimidine-2,4-dione intermediate (6) that is formed when 5-acetoxy-6-acetoxymethyl-1-β-D-(5-O-acetyl-2,3-O-isopropylidene)-ribofuranosyluracil (5) is treated with sodium hydroxide undergoes cyclization at pH 14 to give 2′,3
Publikováno v:
European journal of pharmacology. 266(1)
The present study was undertaken to characterize [3H]ifenprodil binding in rat brain. [3H]Ifenprodil showed saturable, high-affinity binding at 4 degrees C. Specific binding, defined with 10 microM ifenprodil as a competitor, was inhibited biphasical
Publikováno v:
ChemInform. 21