Nonmammalian Models of Huntington's Disease

Autor: Anjalika, Chongtham, Brett, Barbaro, Tomas, Filip, Adeela, Syed, Weijian, Huang, Marianne R, Smith, J Lawrence, Marsh

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1780

Flies, worms, yeast and more recently zebra fish have all been engineered to express expanded polyglutamine repeat versions of Huntingtin with various resulting pathologies including early death, neurodegeneration, and loss of motor function. Each of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a942291d8a3f2958263a211401269f18
https://pubmed.ncbi.nlm.nih.gov/29856015

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Autor: Shane A. Worthge, Adeela Syed, Letizia Magnoni, Michela Camarri, Liliana B. Menalled, J. Lawrence Marsh, Andrea Caricasole, Marco Gianfriddo, Enrica Diodato, Tamas Lukacsovich, Ruth Luthi-Carter, Ozgun Gokce, Judy Purcell, Marianne R. Smith, Luisa Massai, Sylvie Ramboz, Stephen R. Wei, Davide Franceschini, Russell J. Thomas, Giuseppe Pollio, G Westerberg, Bernard Landwehrmeyer, Carla Scali, Brett A. Barbaro, Carol Murphy, Sarah J. Tabrizi

Publikováno v: Human molecular genetics, vol 23, iss 11
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212

Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945f412d35a8fd0b971b3108edc54b4
https://escholarship.org/uc/item/91m8n212

Morphometric analysis of Huntington's disease neurodegeneration in Drosophila

Autor: Wan, Song, Marianne R, Smith, Adeela, Syed, Tamas, Lukacsovich, Brett A, Barbaro, Judith, Purcell, Doug J, Bornemann, John, Burke, J Lawrence, Marsh

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1017

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The HD gene encodes the huntingtin protein (HTT) that contains polyglutamine tracts of variable length. Expansions of the CAG repeat near the amino terminus to encode 40 o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7adfaf1932550e6169d18e6cdb57b442
https://pubmed.ncbi.nlm.nih.gov/23719906

Transient Isotopic Labeling Studies under Steady-State Conditions in Partial Oxidation of Methane to Formaldehyde over MoO3 Catalysts

Autor: Umit S. Ozkan, Marianne R. Smith

Publikováno v: Journal of Catalysis. 142:226-236

The oxygen insertion pathway over MoO[sub 3] catalysts has been investigated for the partial oxidation of methane to formaldehyde using transient isotopic labeling under steady-state reaction conditions. Catalyst samples preferentially exposing basal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3496c1b78aeb4fc2c2cd82f74874574b
https://doi.org/10.1006/jcat.1993.1203

Effect of surface species on activity and selectivity of MoO3/SiO2 catalysts in partial oxidation of methane to formaldehyde

Autor: S. A. Driscoll, Marianne R. Smith, Umit S. Ozkan, Liping Zhang

Publikováno v: Catalysis Letters. 19:1-15

The effect of the nature of surface species on the activity and selectivity of MoO3/SiO2 catalysts has been investigated for the partial oxidation of methane to formaldehyde. Characterization techniques including BET surface area, ambient and in situ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::531bd999113472348c98b8c9c763a8c4
https://doi.org/10.1007/bf00765197