Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marianne O. Larsen"'
Autor:
Carsten F. Gotfredsen, Marianne O. Larsen, Zaki Salanti, Lotte Bjerre Knudsen, Anne-Marie Mølck, Inger Thorup, Niels C. Berg Nyborg
Publikováno v:
Diabetes. 63:2486-2497
Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histolo
Publikováno v:
Acta Pharmacologica Sinica. 33:173-181
Obesity and obesity-related metabolic diseases represent a growing socioeconomic problem throughout the world. Great emphasis has been put on establishing treatments for this condition, including pharmacological intervention. However, there are many
Autor:
Katarina Jelic, Marianne O. Larsen, Bo Ahrén, Richard D. Carr, Jens J. Holst, Carolyn F. Deacon, Jenny Vikman, Ola Lindgren
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:872-878
Context: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are cleaved by dipeptidyl peptidase-4 (DPP-4); plasma activity of DPP-4 may be increased in obesity. The impact of this increase on incretin hormone secre
Autor:
Carolyn F. Deacon, Maria Sörhede Winzell, Katarina Jelic, Ola Lindgren, Bo Ahrén, Richard D. Carr, Marianne O. Larsen
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E779-E784
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet function after carbohydrate ingestion. Whether incretin hormones are of importance for islet function after ingestion of noncarbohydrate macronutrie
Autor:
Katarina Jelic, Carolyn F. Deacon, Bo Ahrén, P. Thomas Gunnarsson, Maria Sörhede Winzell, Richard D. Carr, Marianne O. Larsen
Publikováno v:
Endocrinology. 147:3173-3180
Monounsaturated fatty acids, such as oleic acid (OA), and certain milk proteins, especially whey protein (WP), have insulinotropic effects and can reduce postprandial glycemia. This effect may involve the incretin hormones glucose-dependent insulinot
Autor:
Marianne O. Larsen, Bidda Rolin, Richard D. Carr, Carsten F. Gotfredsen, Michael Wilken, Niels Pørksen, Jeppe Sturis
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 290:E670-E677
At present, the best available estimators of β-cell mass in humans are those based on measurement of insulin levels or appearance rates in the circulation. In several animal models, these estimators have been validated against β-cell mass in lean a
Autor:
Claus B. Juhl, Michael Wilken, Bidda Rolin, Ulla Ribel, Niels Pørksen, Carsten F. Gotfredsen, Marianne O. Larsen, Richard D. Carr
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 288:E412-E421
Herein, we bridge beta-cell function and morphology in minipigs. We hypothesized that different aspects of beta-cell dysfunction are present in obesity and obesity with reduced beta-cell mass by using pulsatile insulin secretion as an early marker. M
Publikováno v:
Diabetologia. 47:1873-1878
A progressive loss of beta cell function and mass are important contributory factors in the development and progression of type 2 diabetes. The aim of this study was to evaluate the effects of a primary reduction in beta cell mass on beta cell functi
Autor:
Marianne O. Larsen, Bidda Rolin
Publikováno v:
ILAR Journal. 45:303-313
Animal models of type 1 diabetes remain essential tools for investigation of the etiology and pathogenesis of the disease and, importantly, for the development of effective new treatments. Although a range of well-characterized and widely used models
Autor:
Carsten F. Gotfredsen, Michael Wilken, Bidda Rolin, Ulla Ribel, Ove Svendsen, Carolyn F. Deacon, Marianne O. Larsen, Richard D. Carr
Publikováno v:
Experimental Diabesity Research
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important in blood glucose regulation.However, both incretin hormones are rapidly degraded by the enzyme dipeptidyl peptidase IV (DPPIV).