Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Marianne M Lee"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Although immune checkpoint inhibitors (ICIs) have been shown to yield promising therapeutic outcomes in a small subset of patients with triple negative breast cancer (TNBC), the majority of patients either do not respond or subsequently de
Externí odkaz:
https://doaj.org/article/5dc74c03c0024904801f2397e4b72253
Autor:
Manoj S Nair, Marianne M Lee, Astrid Bonnegarde-Bernard, Julie A Wallace, Donald H Dean, Michael C Ostrowski, Richard W Burry, Prosper N Boyaka, Michael K Chan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127669 (2015)
Protein delivery platforms are important tools in the development of novel protein therapeutics and biotechnologies. We have developed a new class of protein delivery agent based on sub-micrometer-sized Cry3Aa protein crystals that naturally form wit
Externí odkaz:
https://doaj.org/article/478bc650b8b742feb4ba93b78b2255eb
Autor:
Wenxiu Zhang, Zaofeng Yang, Jiale Zheng, Kaili Fu, Jack Ho Wong, Yunbi Ni, Tzi Bun Ng, Chi Hin Cho, Michael K. Chan, Marianne M. Lee
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Helicobacter pylori (H. pylori) causes infection in the stomach and is a major factor for gastric carcinogenesis. The application of antimicrobial peptides (AMPs) as an alternative treatment to traditional antibiotics is limited by their fac
Externí odkaz:
https://doaj.org/article/20d543b4651740d89077bc1f831a2647
Publikováno v:
Toxins, Vol 14, Iss 12, p 823 (2022)
The crystal protein Cry5B, a pore-forming protein produced by the soil bacterium Bacillus thuringiensis, has been demonstrated to have excellent anthelmintic activity. While a previous structure of the three-domain core region of Cry5B(112–698) had
Externí odkaz:
https://doaj.org/article/3297a130007e4b1fac42f837a6b409b9
Publikováno v:
Biotechnology for Biofuels, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background We have recently developed a one-step, genetically encoded immobilization approach based on fusion of a target enzyme to the self-crystallizing protein Cry3Aa, followed by direct production and isolation of the fusion crystals fro
Externí odkaz:
https://doaj.org/article/6c24578971ce48e588d19c5f1fbbc204
Autor:
Jingxuan Tai, Lin Wang, Wai Shan Chan, Jiahui Cheng, Yuk Hei Chan, Marianne M. Lee, Michael K. Chan
Publikováno v:
Journal of the American Chemical Society. 145:10249-10258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee82cdb8facce92fd6faa487390ae4f1
https://doi.org/10.1021/jacs.3c01291
https://doi.org/10.1021/jacs.3c01291
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The use of immobilized enzymes as biocatalysts has great potential to improve the efficiency and environmental sustainability of many industrial processes. Here, we report a novel approach that allows for the direct production of a highly ac
Externí odkaz:
https://doaj.org/article/c38eb2df5dcc40cdb2c520c9462177cd
Publikováno v:
Acta Biomaterialia. 135:582-592
The tumor suppressor p16 protein is an endogenous CDK4/6 inhibitor. Inactivation of its encoding gene is found in nearly half of human cancers. Restoration of p16 function via adenovirus-based gene delivery has been shown to be effective in suppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d10a563f1eff2fafb73bbdb5dc2573
https://doi.org/10.1016/j.actbio.2021.08.054
https://doi.org/10.1016/j.actbio.2021.08.054
Publikováno v:
Journal of the American Chemical Society. 142:9879-9883
Cry3Aa is a protein that forms crystals naturally in the bacterium Bacillus thuringiensis. Here we report that coexpression of Cry3Aa and a Proteus mirabilis lipase without recombinant fusion results in the efficient passive entrapment of the lipase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce96982fcd0d9ba71f01d29db903326
https://doi.org/10.1021/jacs.9b13462
https://doi.org/10.1021/jacs.9b13462
Publikováno v:
Lab on a chip. 21(11)
Red blood cells (RBCs) are attractive carriers of biomolecular payloads due to their biocompatibility and the ability to shelter their encapsulated cargo. Commonly employed strategies to encapsulate payloads into RBCs, such as hypotonic shock, membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f30028c1cb0eec1ea522ed0a063a998
https://pubmed.ncbi.nlm.nih.gov/34002198
https://pubmed.ncbi.nlm.nih.gov/34002198