Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Marianne M Lee"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Although immune checkpoint inhibitors (ICIs) have been shown to yield promising therapeutic outcomes in a small subset of patients with triple negative breast cancer (TNBC), the majority of patients either do not respond or subsequently de
Externí odkaz:
https://doaj.org/article/5dc74c03c0024904801f2397e4b72253
Autor:
Manoj S Nair, Marianne M Lee, Astrid Bonnegarde-Bernard, Julie A Wallace, Donald H Dean, Michael C Ostrowski, Richard W Burry, Prosper N Boyaka, Michael K Chan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127669 (2015)
Protein delivery platforms are important tools in the development of novel protein therapeutics and biotechnologies. We have developed a new class of protein delivery agent based on sub-micrometer-sized Cry3Aa protein crystals that naturally form wit
Externí odkaz:
https://doaj.org/article/478bc650b8b742feb4ba93b78b2255eb
Autor:
Jingxuan Tai, Lin Wang, Wai Shan Chan, Jiahui Cheng, Yuk Hei Chan, Marianne M. Lee, Michael K. Chan
Publikováno v:
Journal of the American Chemical Society. 145:10249-10258
Publikováno v:
Acta Biomaterialia. 135:582-592
The tumor suppressor p16 protein is an endogenous CDK4/6 inhibitor. Inactivation of its encoding gene is found in nearly half of human cancers. Restoration of p16 function via adenovirus-based gene delivery has been shown to be effective in suppressi
Publikováno v:
Toxins. 14(12)
The crystal protein Cry5B, a pore-forming protein produced by the soil bacterium
Publikováno v:
Journal of the American Chemical Society. 142:9879-9883
Cry3Aa is a protein that forms crystals naturally in the bacterium Bacillus thuringiensis. Here we report that coexpression of Cry3Aa and a Proteus mirabilis lipase without recombinant fusion results in the efficient passive entrapment of the lipase
Publikováno v:
Lab on a chip. 21(11)
Red blood cells (RBCs) are attractive carriers of biomolecular payloads due to their biocompatibility and the ability to shelter their encapsulated cargo. Commonly employed strategies to encapsulate payloads into RBCs, such as hypotonic shock, membra
Autor:
Michael K. Chan, Jiale Zheng, Marianne M. Lee, Zhen Liu, Tak Hang Chan, Zaofeng Yang, Iris L. K. Wong, Larry M.C. Chow, Chin Fung Chan, Xianliang Zhao
Publikováno v:
Antimicrob Agents Chemother
We have designed, synthesized, and characterized a library of 38 novel flavonoid compounds linked with amines. Some of these amine-linked flavonoids have potent in vitro activity against parasites that cause cutaneous leishmaniasis, a tropical diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1dfb6e24f4e2b298f6ae3a1abd42f6
https://europepmc.org/articles/PMC8092861/
https://europepmc.org/articles/PMC8092861/
Publikováno v:
Cell chemical biology. 28(2)
The accumulation of α-synuclein amyloid fibrils in the brain is linked to Parkinson's disease and other synucleinopathies. The intermediate species in the early aggregation phase of α-synuclein are involved in the emergence of amyloid toxicity and
Publikováno v:
Biomaterials. 271:120759
Direct delivery of proteins into cells holds significant potential for basic research and drug development. However, the poor endosomal escape of conventional delivery strategies remains a challenge, thus limiting the clinical translation of many pro