Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Marianne L. Spatz"'
Autor:
Prasanthi Geda, Mark A. McCoy, Liping Yang, Chaomin Li, Armetta D. Hill, Xavier Fradera, Marianne L. Spatz, Matthew Ernst Voss, Carolyn Michele Cammarano, Pierre Daublain, Xiao Wang, Christopher F. Thompson, B. Wesley Trotter, C. Gary Marshall, Michael H. Reutershan, Peter Goldenblatt, Latha G. Nair, Manami Shizuka, Tammie C. Yeh, John G. Cryan, Isabelle Dussault, Michelle Martinez, Mingmei Cai, Raymond A. Kemper, Binyuan Sun, Michelle R. Machacek, Dietrich Steinhuebel, Giovanna Scapin, Michael D. Altman, Stephane L. Bogen, Matthew Christopher, Dapeng Chen, Victoria Kutilek, Weidong Pan
Publikováno v:
Journal of Medicinal Chemistry. 64:16213-16241
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f003ba884dc7f950fc132b2a33cadf
https://doi.org/10.1021/acs.jmedchem.1c01524
https://doi.org/10.1021/acs.jmedchem.1c01524
Autor:
Michael H, Reutershan, Michelle R, Machacek, Michael D, Altman, Stephane, Bogen, Mingmei, Cai, Carolyn, Cammarano, Dapeng, Chen, Matthew, Christopher, John, Cryan, Pierre, Daublain, Xavier, Fradera, Prasanthi, Geda, Peter, Goldenblatt, Armetta D, Hill, Raymond A, Kemper, Victoria, Kutilek, Chaomin, Li, Michelle, Martinez, Mark, McCoy, Latha, Nair, Weidong, Pan, Christopher F, Thompson, Giovanna, Scapin, Manami, Shizuka, Marianne L, Spatz, Dietrich, Steinhuebel, Binyuan, Sun, Matthew E, Voss, Xiao, Wang, Liping, Yang, Tammie C, Yeh, Isabelle, Dussault, C Gary, Marshall, B Wesley, Trotter
Publikováno v:
Journal of medicinal chemistry. 64(21)
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c70be0458a74b9595c42b9269bd0b63
https://pubmed.ncbi.nlm.nih.gov/34714078
https://pubmed.ncbi.nlm.nih.gov/34714078
Publikováno v:
Diabetes. 55(5)
The glucoincretin hormone glucagon-like peptide-1 (GLP-1) increases pancreatic beta-cell proliferation and survival through sequential activation of the epidermal growth factor receptor (EGFR), phosphatidylinositol-3 kinase (PI 3-kinase), and Akt. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00caeb57ceb406e054bce1a6b713ac20
https://pubmed.ncbi.nlm.nih.gov/16644672
https://pubmed.ncbi.nlm.nih.gov/16644672
Autor:
Philip E. Brandish, Erica Leccese, Marianne L. Spatz, François G. Gervais, John H. Shin, Alexandra Hicks, Jie Zhang-Hoover
Publikováno v:
Journal of Pharmacological and Toxicological Methods. :61-67
Introduction Whole blood functional assays are pharmacologically relevant in the drug discovery process to evaluate potency in a relevant biological matrix, to support establishment of PK/PD relationships and to aid in human dose predictions. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3287ccf8ff1d5ae9339a10b476604f85