Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marianne Keisu"'
Publikováno v:
American Journal of Hematology. 84:428-434
The incidence of drug-induced neutropenia has not changed in the western hemisphere over the last 30 years. Yet, the drug panorama has changed considerably. This implies that host factors may play an intriguing role for this idiosyncratic reaction. T
Publikováno v:
European Journal of Clinical Pharmacology. 65:1025-1035
The aims of the present analysis were to determine prevalence of transaminase elevation in placebo-treated healthy volunteers in our historical phase I clinical trials and to assess which factors were associated with it. We performed a retrospective
Publikováno v:
European Journal of Haematology. 57:47-52
Two hypotheses were examined in the combined data from 3 case-control studies of aplastic anaemia, conducted in Thailand, Europe/Israel and the US: 1. Cases exposed to drugs associated with a significantly increased risk of aplastic anaemia are more
Autor:
Marianne Keisu, Neil Young
Publikováno v:
European Journal of Haematology. 57:125-129
Publikováno v:
Stephens' Detection and Evaluation of Adverse Drug Reactions: Principles and Practice, Sixth Edition
All clinical trials should have a safety component as a primary or secondary objective. In early Phase I and Phase II trials, safety and tolerability are often a primary objective and the main reason for conducting the study. In later Phase II and Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1f06705c72d6b8e8459ed698310089
https://doi.org/10.1002/9780470975053.ch4
https://doi.org/10.1002/9780470975053.ch4
Publikováno v:
Pharmaceutical Sciences Encyclopedia
An adverse drug reaction (ADR) is an adverse event where a causal relationship between the adverse event (AE) and the medicinal product is at least a reasonable possibility. Lack of safety remains the major cause of attrition during clinical developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ffb53cde05a4c59e9e72e6e4e690d9
https://doi.org/10.1002/9780470571224.pse203
https://doi.org/10.1002/9780470571224.pse203
Publikováno v:
Scandinavian Journal of Infectious Diseases. 23:489-493
Side-effects of proguanil reported to the Swedish Adverse Drug Reaction (ADR) register from 1981 to 1988 are described and related to sales figures of the drug in Sweden during the same period. One serious reaction, thrombocytopenia, and 7 minor reac
Autor:
Laurent Auclert, James H. Lewis, Dominique Larrey, Sunita B. Sheth, Rolf Olsson, Marianne Keisu, William M. Lee
Publikováno v:
Drug safety. 28(4)
In clinical trials, the efficacy and safety of the oral direct thrombin inhibitor ximelagatran have been evaluated in the prevention or treatment of thromboembolic conditions known to have high morbidity and mortality. In these studies, raised aminot
Autor:
Neil Young, Marianne Keisu
Publikováno v:
European Journal of Haematology. 57:5-5
Publikováno v:
Archives of dermatology. 126(7)
• During the 17-year period 1972 through 1988, a total of seven cases of agranulocytosis associated with the use of dapsone for the treatment of dermatitis herpetiformis were reported in Sweden. The median age of the patients involved was 61 years;