Hemoglobin is a co-factor of human trypanosome lytic factor.

Autor: Justin Widener, Marianne Jensby Nielsen, April Shiflett, Søren Kragh Moestrup, Stephen Hajduk

Publikováno v: PLoS Pathogens, Vol 3, Iss 9, Pp 1250-1261 (2007)

Trypanosome lytic factor (TLF) is a high-density lipoprotein (HDL) subclass providing innate protection to humans against infection by the protozoan parasite Trypanosoma brucei brucei. Two primate-specific plasma proteins, haptoglobin-related protein

Externí odkaz: https://doaj.org/article/91a17c9095d24140a2ea04a9729b6191

Soluble CD163 levels in children with sickle cell disease

Autor: Holger Jon Møller, Søren K. Moestrup, Jack Bartram, Marianne Jensby Nielsen, Sue Height, Moira C. Dick, David C. Rees

Publikováno v: British Journal of Haematology. 153:105-110

Summary Sickle cell disease (SCD) is characterized by vasculopathy, which has been causally linked to intravascular haemolysis and high levels of free plasma haemoglobin. Soluble CD163 (sCD163) is implicated in the clearance of free plasma haemoglobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb6b86806b91c74d196c59866668fc97
https://doi.org/10.1111/j.1365-2141.2011.08580.x

A Haptoglobin-Hemoglobin Receptor Conveys Innate Immunity to Trypanosoma brucei in Humans

Autor: Etienne Pays, Patricia Tebabi, Géraldine De Muylder, Martine Raes, Annette Pays, Marianne Jensby Nielsen, Søren K. Moestrup, Benoit Vanhollebeke, Marc Dieu

Publikováno v: Science. 320:677-681

The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein. We report that this process is mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfaa522bee15355283506cca07d3075
https://doi.org/10.1126/science.1156296

A Unique Loop Extension in the Serine Protease Domain of Haptoglobin Is Essential for CD163 Recognition of the Haptoglobin-Hemoglobin Complex

Autor: Jan J. Enghild, Christian Bøtcher Jacobsen, Steen V. Petersen, Marianne Jensby Nielsen, Søren K. Moestrup, Jonas Heilskov Graversen, Søren Thirup

Publikováno v: Nielsen, M J, Petersen, S V, Jacobsen, C, Thirup, S S, Enghild, J J, Graversen, J H & Moestrup, S K 2007, ' A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex ', Journal of Biological Chemistry, vol. 282, no. 2, pp. 1072-1079 .
Aarhus University

Haptoglobin and haptoglobin-related protein are homologous hemoglobin-binding proteins consisting of a complement control repeat (alpha-chain) and a serine protease domain (beta-chain). Haptoglobin-hemoglobin complex formation promotes high affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599def8325b660fa78faa2d2e820f389
https://doi.org/10.1074/jbc.m605684200

The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants

Autor: Søren K. Moestrup, Marianne Jensby Nielsen, Holger Jon Møller, Mette Madsen

Publikováno v: Nielsen, M J, Madsen, M, Møller, H J & Moestrup, S K 2006, ' The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants ', J. Leukoc. Biol., vol. 79, pp. 837-845 .

CD163 is the monocyte/macrophage-specific receptor for haptoglobin-hemoglobin (Hp-Hb) complexes. The cytoplasmic tail of human CD163 exists as a short tail variant and two long tail variants. Reverse transcriptase-polymerase chain reaction analysis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf4825d152bce8af23f649a4b03e474
https://doi.org/10.1189/jlb.1005602