Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marianne Heitzmann"'
Autor:
Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in
Externí odkaz:
https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340
Autor:
Christian Schmidt-Lauber, Saliha Harrach, Thomas Pap, Meike Fischer, Marion Victor, Marianne Heitzmann, Uwe Hansen, Manfred Fobker, Stefan-Martin Brand, Aleksandra Sindic, Hermann Pavenstädt, Bayram Edemir, Eberhard Schlatter, Jessica Bertrand, Giuliano Ciarimboli
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52247 (2012)
BACKGROUND: Tyrosine kinase inhibitors (TKIs) are effective in treating malignant disorders and were lately suggested to have an impact on non-malignant diseases. However, in some inflammatory conditions like rheumatoid arthritis (RA) the in vivo eff
Externí odkaz:
https://doaj.org/article/943d0cf915ef42f6b13bdebd7ebf451e
Autor:
Rizi Ai, Uwe Hansen, Johanna Intemann, Elsa Leitão, Toni Weinhage, Isabell Begemann, Joachim Kremerskothen, Anja Römer-Hillmann, Ho-Ryun Chung, Marianne Heitzmann, Thomas Pap, Hermann Pavenstädt, Hans P. Kiener, Na Li, Annika Krause, Wei Wang, Gilles Gasparoni, Berno Dankbar, Sylvia Müller, Corinna Wehmeyer, Denise Beckmann, Dirk Foell, Philip Rosenstiel, Bernhard Horsthemke, Thomas Kamradt, Adelheid Korb-Pap, Karl Nordström, Hans Schnittler, David J. J. de Gorter, Nico Lindemann, Jörn Walter, Gary S. Firestein, Xinyi Yang, Nina Gasparoni, Christopher Schröder, Jan Hillen, Milos Galic
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186d00758ac40be110c81701778639ee
http://europepmc.org/articles/PMC8206096
http://europepmc.org/articles/PMC8206096
Autor:
Anna-Isabelle Kälsch, Marianne Heitzmann, Lovis Kling, Lisa Leikeim, Urs Benck, Annette Breedijk, Benito A. Yard, Stefan Porubsky, Bernhard K. Krämer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c12376d2a4d929d47d28d91c8399636
http://link.springer.com/article/10.1038/s41598-017-12011-4
http://link.springer.com/article/10.1038/s41598-017-12011-4
Autor:
Annika Krause, Ina Winkler, Christiane Geyer, Jan Hillen, Denise Beckmann, Thomas Pap, Marianne Heitzmann, Adelheid Korb-Pap, Christoph Bremer, Hermann Pavenstädt
Publikováno v:
Arthritis Research & Therapy
Background Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the bloodstream from sites of cartilage destruction to new locations where they reinitiate the destructive processes at distant articular cartilage surfaces. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7460c4c5a8c475b2fe8a7ff627c2e9
https://doi.org/10.1186/s13075-017-1245-9
https://doi.org/10.1186/s13075-017-1245-9
Autor:
Svetlana Frank, Marvin A Peters, Corinna Wehmeyer, Simon Strietholt, Christina Koers-Wunrau, Jessica Bertrand, Marianne Heitzmann, Anja Hillmann, Joanna Sherwood, Christine Seyfert, Steffen Gay, Thomas Pap
Publikováno v:
Annals of the Rheumatic Diseases. 72:1874-1881
Objective Based on previous data that have linked the small ubiquitin-like modifier-1 (SUMO-1) to the pathogenesis of rheumatoid arthritis (RA), we have investigated the expression of the highly homologous SUMO family members SUMO-2/3 in human RA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b0ae401269c9c18e848136ec184e87
https://doi.org/10.1136/annrheumdis-2012-202080
https://doi.org/10.1136/annrheumdis-2012-202080
Synovial joints are composed of different morphological structures that have their distinct cellular and biochemical properties. Articular cartilage and synovial membrane are key components of synovial joints and show a number of peculiarities that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc82994a641a8f7883d8646cc7cb302
https://doi.org/10.1093/med/9780199642489.003.0056
https://doi.org/10.1093/med/9780199642489.003.0056
Autor:
Stefan Butz, Jan Hillen, Thomas Pap, Marianne Heitzmann, Catherine S. Chew, Uwe Hansen, Hans P. Kiener, Hans-Joachim Galla, Denise Beckmann, Adelheid Korb-Pap, H Pavenstädt, Dietmar Vestweber
Publikováno v:
Annals of the Rheumatic Diseases. 75:A78.2-A78
Background and objectives The LIM-and-SH3-domain-protein-1 (Lasp-1) is an actin-associated protein and is localised at focal adhesion sites where it is involved in organisation of actin polymerization and focal adhesion turnover prozesses. We investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33855323ceef979eb57b73ca794e902e
https://doi.org/10.1136/annrheumdis-2016-209124.187
https://doi.org/10.1136/annrheumdis-2016-209124.187
Autor:
Eberhard Schlatter, Jessica Bertrand, Stefan-Martin Brand, Saliha Harrach, Bayram Edemir, Marion Victor, Aleksandra Sindic, Uwe Hansen, Christian Schmidt-Lauber, Giuliano Ciarimboli, Manfred Fobker, Hermann Pavenstädt, Meike Fischer, Thomas Pap, Marianne Heitzmann
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52247 (2012)
PLoS ONE
PLoS ONE
Background: Tyrosine kinase inhibitors (TKIs) are effective in treating malignant disorders and were lately suggested to have an impact on non-malignant diseases. However, in some inflammatory conditions like rheumatoid arthritis (RA) the in vivo eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278eee77398532549920b7ebdbc428b7
http://europepmc.org/articles/PMC3527388?pdf=render
http://europepmc.org/articles/PMC3527388?pdf=render
Autor:
Dietmar Vestweber, Hans-Joachim Galla, Thomas Pap, Adelheid Korb-Pap, Uwe Hansen, Stefan Butz, Denise Beckmann, Marianne Heitzmann, Catherine S. Chew, Jan Hillen, H Pavenstädt
Publikováno v:
Annals of the Rheumatic Diseases. 74:A20.1-A20
Background and objectives Lasp-1 (LIM-and-SH3-domain-protein-1) is an actin-binding protein that modifies cytoskeleton organisation and is localised at cell-matrix interaction sites where it is involved in cell adhesion, migration and metastatic inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81503f0038c7e9c3bb71871dc151069
https://doi.org/10.1136/annrheumdis-2015-207259.46
https://doi.org/10.1136/annrheumdis-2015-207259.46