Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marianne Habdank"'
Autor:
Frank Stegelmann, Lars Bullinger, Martin Griesshammer, Karlheinz Holzmann, Marianne Habdank, Susanne Kuhn, Carmen Maile, Stefanie Schauer, Hartmut Döhner, Konstanze Döhner
Publikováno v:
Haematologica, Vol 95, Iss 4 (2010)
Single-nucleotide polymorphism arrays allow for genome-wide profiling of copy-number alterations and copy-neutral runs of homozygosity at high resolution. To identify novel genetic lesions in myeloproliferative neoplasms, a large series of 151 clinic
Externí odkaz:
https://doaj.org/article/f3bb96b70ed447dcbba18369548cf9f9
Autor:
Richard F. Schlenk, Konstanze Döhner, Michael Kneba, Katharina Götze, Frank Hartmann, Francesco del Valle, Heinz Kirchen, Elisabeth Koller, Jörg T. Fischer, Lars Bullinger, Marianne Habdank, Daniela Späth, Silja Groner, Bernhard Krebs, Sabine Kayser, Andrea Corbacioglu, Andreas Anhalt, Axel Benner, Stefan Fröhling, Hartmut Döhner
Publikováno v:
Haematologica, Vol 94, Iss 1 (2009)
Background In a previous randomized trial, AML HD98B, we showed that administration of all-trans retinoic acid in addition to intensive chemotherapy improved the outcome of older patients with acute myeloid leukemia. The objectives of this study were
Externí odkaz:
https://doaj.org/article/2185ff8a4507470b99c9f55d2382c982
Autor:
Verena I. Gaidzik, Peter Paschka, Daniela Späth, Marianne Habdank, Claus-Henning Köhne, Ulrich Germing, Marie von Lilienfeld-Toal, Gerhard Held, Heinz-August Horst, Detlef Haase, Martin Bentz, Katharina Götze, Hartmut Döhner, Richard F. Schlenk, Lars Bullinger, Konstanze Döhner
Publikováno v:
Journal of Clinical Oncology. 30:1350-1357
Purpose The tet oncogene family member 2 (TET2) gene was recently identified to be mutated in myeloid disorders including acute myeloid leukemia (AML). To date, there is increasing evidence for a functional role of TET2 mutations (TET2mut) in AML. Th
Autor:
Marie von Lilienfeld-Toal, Thomas Kindler, Verena I. Gaidzik, Daniela Späth, Arnold Ganser, Karina Eiwen, Hartmut Döhner, Peter Paschka, Florian Tschürtz, Jan Krönke, Brigitte Schlegelberger, Gudrun Göhring, Richard F. Schlenk, Gerhard Held, Michael Lübbert, Jürgen Krauter, Mohammed Wattad, Ulrich Germing, Marianne Habdank, Helmut R. Salih, David Nachbaur, Kai-Ole Jensen, Detlef Haase, Hans-Günther Mergenthaler, Andrea Corbacioglu, Konstanze Döhner, Shiva Onken
Publikováno v:
Journal of Clinical Oncology. 29:2709-2716
Purpose To evaluate the prognostic value of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) with NPM1 mutation (NPM1mut). Patients and Method RNA-based real-time quantitative polymerase chain reaction (RQ-PCR) specific fo
Autor:
Richard F. Schlenk, Sabine Kayser, Peter Paschka, Katharina Götze, Manuela Zucknick, Daniela Späth, Lars Bullinger, Ulrich Germing, Konstanze Döhner, Hartmut Döhner, Marianne Habdank, Jan Krönke, Heinz-A. Horst, Verena I. Gaidzik
Publikováno v:
Journal of Clinical Oncology. 28:3636-3643
Purpose To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations in acute myeloid leukemia (AML). Patients and Methods We studied 805 adults (age range, 16 to 60 years) with A
Autor:
Hartmut Döhner, Lars Bullinger, Stefanie Schauer, Karlheinz Holzmann, Carmen Maile, Frank Stegelmann, Marianne Habdank, Martin Griesshammer, Susanne Kuhn, Konstanze Döhner
Publikováno v:
Haematologica. 95:666-669
Single-nucleotide polymorphism arrays allow for genome-wide profiling of copy-number alterations and copy-neutral runs of homozygosity at high resolution. To identify novel genetic lesions in myeloproliferative neoplasms, a large series of 151 clinic
Autor:
Mridul Agrawal, Nikolaus Jahn, Gina Walter, Hartmut Döhner, Claudia D. Baldus, Lars Fransecky, Stefan Fröhling, Michael Lübbert, Konstanze Döhner, Patrizia Jensen, Ralph Wäsch, Richard F. Schlenk, Claudia Scholl, Marianne Habdank
Publikováno v:
Blood. 128:1608-1608
Background: Approximately 5% of adult acute myeloid leukemia (AML) cases are associated with balanced translocations of chromosome 11q23, and AML with t(9;11)(p22;q23) is recognized as a distinct entity by the WHO Classification. Similarly, the prese
Autor:
Marie von Lilienfeld-Toal, Richard F. Schlenk, Konstanze Döhner, Lars Bullinger, Thorsten Zenz, Hartmut Döhner, Frank G. Rücker, Helena Kett, Peter Lichter, Sabine Kayser, Jürgen Krauter, Brigitte Schlegelberger, Stefan Fröhling, Marianne Habdank, Arnold Ganser, Peter Paschka, Karlheinz Holzmann, Veronica Teleanu, Michael Lübbert, Carla Maria Kugler, Verena I. Gaidzik, Gerhard Held
Publikováno v:
Blood. 119(9)
Abstract 3558 Acute myeloid leukemia with complex karyotype (CK-AML, CK+) is defined as ≥3 acquired chromosome abnormalities in the absence of recurrent genetic abnormalities (WHO 2008). CK-AML account for 10–15% of all AML and are characterized
Autor:
Richard F, Schlenk, Konstanze, Döhner, Jürgen, Krauter, Stefan, Fröhling, Andrea, Corbacioglu, Lars, Bullinger, Marianne, Habdank, Daniela, Späth, Michael, Morgan, Axel, Benner, Brigitte, Schlegelberger, Gerhard, Heil, Arnold, Ganser, Hartmut, Döhner, L, Noens
Publikováno v:
The New England journal of medicine. 358(18)
Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein alpha gene (CEPBA), the myeloid-lymphoid o
Autor:
Marianne Habdank, Stefan Fröhling, Claudia Scholl, Andrea Corbacioglu, F.G. Rücker, Hartmut Döhner, Konstanze Döhner, Lars Bullinger, Richard F. Schlenk
Publikováno v:
Blood. 106(12)
To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic shuttle protein in younger adults with acute myeloid leukemia (AML) and normal cytogenetics, sequencing of NPM1 exon 12 was performed in diagnostic samples