Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marianne Goodwin"'
Autor:
Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The precise timing of neurodevelopmental splicing switches and the underlying regulatory mechanisms remain poorly understood. This study identifies two major waves of developmental switches under the control of distinct combinations of RNA-binding pr
Externí odkaz:
https://doaj.org/article/e95f34f767ed420686c114eb449248ee
Autor:
Marianne Goodwin, Apoorva Mohan, Ranjan Batra, Kuang-Yung Lee, Konstantinos Charizanis, Francisco José Fernández Gómez, Sabiha Eddarkaoui, Nicolas Sergeant, Luc Buée, Takashi Kimura, H. Brent Clark, Joline Dalton, Kenji Takamura, Sebastien M. Weyn-Vanhentenryck, Chaolin Zhang, Tammy Reid, Laura P.W. Ranum, John W. Day, Maurice S. Swanson
Publikováno v:
Cell Reports, Vol 12, Iss 7, Pp 1159-1168 (2015)
For some neurological disorders, disease is primarily RNA mediated due to expression of non-coding microsatellite expansion RNAs (RNAexp). Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their no
Externí odkaz:
https://doaj.org/article/c1f149d4c87f43cf89365b6092f6e218
Autor:
Ciaran M. Lee, Gang Bao, C. S. Bauer, M. Garcia-Lloret, Ayal Hendel, Adam Sheikali, Rosa Bacchetta, Ami J. Shah, Federica Barzaghi, Alice Bertaina, S. Shipp, Maria Grazia Roncarolo, L. Froessl, Mara Pavel-Dinu, Matt Porteus, U. Lakshmanan, Mansi Narula, Esmond Lee, Holly K. Miller, Manish J. Butte, Marianne Goodwin, Laura Passerini
Publikováno v:
Science advances, vol 6, iss 19
Science Advances
Science Advances
Gene editing of FOXP3 ensures regulated expression and restored function in T cells, supporting clinical applicability.
The prototypical genetic autoimmune disease is immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome,
The prototypical genetic autoimmune disease is immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome,
Autor:
Maria Grazia Roncarolo, Michael Snyder, Alice Bertaina, Silvia Gregori, Yohei Sato, Laura Passerini, Rosa Bacchetta, Molly Javier Uyeda, Marianne Goodwin, Brian D. Piening
Publikováno v:
Clinical & Translational Immunology
Objectives Genetic or acquired defects in FOXP3+ regulatory T cells (Tregs) play a key role in many immune‐mediated diseases including immune dysregulation polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome. Previously, we demonstrated CD4
Autor:
S. Shipp, Matthew H. Porteus, Esmond Lee, Maria Grazia Roncarolo, U. Lakshmanan, Rosa Bacchetta, Marianne Goodwin, Mara Pavel-Dinu
Publikováno v:
Cytotherapy. 22:S20
Background & Aim Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is the prototypical primary immune regulatory disorder caused by mutations in the forkhead box protein 3 (FOXP3) gene, a critical transcription factor re
Autor:
Dmytro Ustianenko, Stavros Lomvardas, Martin Jacko, Ulrich Hengst, Xuegong Zhang, Sebastien M. Weyn-Vanhentenryck, Chaolin Zhang, Maurice S. Swanson, Qinghong Yan, Huijuan Feng, Jose C. Martinez, Rachel Duffié, Marianne Goodwin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated during neurodevelopment. However, the precise timing of developmental splicing switches and the underlying regulatory mechanisms are poorly understood. He
Autor:
Naohiro Terada, Katherine E. Santostefano, S. H. Subramony, Marianne Goodwin, Jilin Liu, Guangbin Xia, Tetsuo Ashizawa, Maurice S. Swanson
Publikováno v:
Cellular Reprogramming. 15:166-177
Dystrophia myotonica type 1 (DM1) is an autosomal dominant multisystem disorder. The pathogenesis of central nervous system (CNS) involvement is poorly understood. Disease-specific induced pluripotent stem cell (iPSC) lines would provide an alternati
Autor:
Marianne Goodwin, Marcela Nouzova, Fernando G. Noriega, Wolfgang Meyerhof, Jaime G. Mayoral, Anne Brockhoff
Publikováno v:
Peptides. 34:201-208
Allatotropin is an insect neuropeptide with pleiotropic actions on a variety of different tissues. In the present work we describe the identification, cloning and functional and molecular characterization of an Aedes aegypti allatotropin receptor (Ae
Autor:
Marianne Goodwin, Moyi Li, Dustin J. Finn, Chaolin Zhang, Maurice S. Swanson, Apoorva Mohan, Konstantinos Charizanis, Charles A. Thornton, Krzysztof Sobczak, Mini Manchanda, Ranjan Batra
Publikováno v:
Molecular cell. 56(2)
Inhibition of muscleblind-like (MBNL) activity due to sequestration by microsatellite expansion RNAs is a major pathogenic event in the RNA-mediated disease myotonic dystrophy (DM). Although MBNL1 and MBNL2 bind to nascent transcripts to regulate alt
Publikováno v:
Brain research. 1584
A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the pro