Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marianne Broome-Powell"'
Autor:
Graeme Walker, Nicholas Hayward, Mariano Barbacid, Marcos Malumbres, Marianne Broome Powell, Sandra Pavey, Douglas Lincoln, Brian Gabrielli, Nicole Irwin, H. Konrad Muller, Elke Hacker
Human melanoma susceptibility is often characterized by germ-line inactivating CDKN2A (INK4A/ARF) mutations, or mutations that activate CDK4 by preventing its binding to and inhibition by INK4A. We have previously shown that a single neonatal UV radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f55593d59863bb0fa9e6010dd6fb0a
https://doi.org/10.1158/0008-5472.c.6494867
https://doi.org/10.1158/0008-5472.c.6494867
Autor:
Graeme Walker, Nicholas Hayward, Mariano Barbacid, Marcos Malumbres, Marianne Broome Powell, Sandra Pavey, Douglas Lincoln, Brian Gabrielli, Nicole Irwin, H. Konrad Muller, Elke Hacker
Supplementary Figures 1-2, Table 1 from Spontaneous and UV Radiation–Induced Multiple Metastatic Melanomas in Cdk4R24C/R24C/TPras Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9360dcc9282e06a55e6dfb723413bf
https://doi.org/10.1158/0008-5472.22365809
https://doi.org/10.1158/0008-5472.22365809
Autor:
Laura Castellini, Amato J. Giaccia, Marta Vilalta, Elizabeth C. Finger, Dadi Jiang, Erinn B. Rankin, Adam J. Krieg, Alice Banh, Wayne Zundel, Marianne Broome Powell
Publikováno v:
Proceedings of the National Academy of Sciences. 112:4441-4446
Scaffold proteins are critical hubs within cells that have the ability to modulate upstream signaling molecules and their downstream effectors to fine-tune biological responses. Although they can serve as focal points for association of signaling mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57caa28b9cd3a1c1bc4ca45fb69721c1
https://doi.org/10.1073/pnas.1418164112
https://doi.org/10.1073/pnas.1418164112
Publikováno v:
Proceedings of the National Academy of Sciences. 109:15787-15792
Rab4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. The protein TBC1D16 is up-regulated in melanoma, and TBC1D16-overexpressing melanoma cells are dependent on TBC1D16. We show here that TBC1D16 enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0fb177538a9e2e3cd86aa68bda6269
https://doi.org/10.1073/pnas.1204540109
https://doi.org/10.1073/pnas.1204540109
Autor:
Dennis R. Roop, Regan A. Stiegmann, Daisy Dai, Marianne Broome Powell, Victoria Gonzalez, Steven E. Robinson, Kazutoshi Murao, Guillermina Lozano, Neil F. Box, Tamara Terzian, Glen M. Boyle, William A. Robinson, Pamela M. Pollock, Enrique C. Torchia
Publikováno v:
Pigment Cell & Melanoma Research. 23:781-794
p53 is the central member of a critical tumor suppressor pathway in virtually all tumor types, where it is silenced mainly by missense mutations. In melanoma, p53 predominantly remains wild type, thus its role has been neglected. To study the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b66a265efaf507eb4f44e0243b765e
https://doi.org/10.1111/j.1755-148x.2010.00773.x
https://doi.org/10.1111/j.1755-148x.2010.00773.x
Publikováno v:
International Journal of Pharmaceutics. 382:104-110
Apomine is a novel compound that inhibits the mevalonate/isoprenoid pathway of cholesterol synthesis and may prove effective as a skin cancer chemoprevention therapy. This research was focused on the development of a new delivery approach for chemopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a227be563b2f7b818fabc1e3b0a801a3
https://doi.org/10.1016/j.ijpharm.2009.08.016
https://doi.org/10.1016/j.ijpharm.2009.08.016
Autor:
Melony S. O’Neill, Bryan Husbeck, Shoucheng Ning, Marianne Broome Powell, Susan J. Knox, Mark Hsu, Zhijian Chen, Amie J. Dirks, Barbara Bedogni
Publikováno v:
Radiation Research. 168:125-133
The integrins and PI3K/Akt are important mediators of the signal transduction pathways involved in tumor angiogenesis and cell survival after exposure to ionizing radiation. Selective targeting of either integrins or PI3K/Akt can radiosensitize tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918a7c0326a2b9a87edd4e717c9d67e4
https://doi.org/10.1667/rr0829.1
https://doi.org/10.1667/rr0829.1
Autor:
Scott M. Welford, Lorenz Poellinger, Amato J. Giaccia, Barbara Bedogni, Marianne Broome Powell, Katarina Gradin
Publikováno v:
Genes & Development. 20:3366-3371
Premature senescence in vitro has been attributed to oxidative stress leading to a DNA damage response. In the absence of oxidative damage that occurs at atmospheric oxygen levels, proliferation of untransformed cells continues for extended periods o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c480a51daa688b233e10d745a40c970f
https://doi.org/10.1101/gad.1471106
https://doi.org/10.1101/gad.1471106
Publikováno v:
Investigational New Drugs. 25:107-114
Apomine, a novel bisphosphonate ester, has demonstrated anticancer activity in a variety of cancer cell lines; however, its mechanism of cytotoxicity is not well understood. Previous work has demonstrated that Apomine induces cell death by activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a58d5e8d1d9f6c59fdbd78b04876d
https://doi.org/10.1007/s10637-006-9015-6
https://doi.org/10.1007/s10637-006-9015-6
Publikováno v:
Cell Cycle. 5:1258-1261
Melanomagenesis is a complex phenomenon in which environmental, genetic and host factors play a role. Sun burns in early childhood are a known risk factor in melanoma development. Alteration of prosurvival genes such as Ras and Akt and loss of functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3926b0cf0b32c2b50105d7eb69f9d036
https://doi.org/10.4161/cc.5.12.2810
https://doi.org/10.4161/cc.5.12.2810