Výsledky vyhledávání - "Marianne Bizzozzero-Hiriart"

Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice

Autor: Noelia P. Di Giorgio, Marianne Bizzozzero-Hiriart, Pablo N. Surkin, Esteban Repetto, María M. Bonaventura, Florencia N. Tabares, Nadia S. Bourguignon, Ayelén Converti, Juan M. Riaño Gomez, Bernhard Bettler, Victoria Lux-Lantos

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 324:E314-E329

We developed a unique mouse lacking GABAB receptors specifically in Kiss1 cells to evaluate the impact on reproduction and metabolism. Knockout males showed a severe impact on glucose homeostasis, which worsened with aging. These results reinforce th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef82d655ad1f85f793c1b09db6e398b7
https://doi.org/10.1152/ajpendo.00129.2022

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GABAB Receptor Antagonism from Birth to Weaning Permanently Modifies Kiss1 Expression in the Hypothalamus and Gonads in Mice

Autor: Marianne Bizzozzero-Hiriart, Noelia P. Di Giorgio, Carlos Libertun, Victoria A.R. Lux-Lantos

Publikováno v: Neuroendocrinology. 112:998-1026

Introduction: The kisspeptin gene Kiss1 is expressed in two hypothalamic areas: anteroventral periventricular nucleus/periventricular nucleus (AVPV/PeN) and arcuate nucleus (ARC), and also in gonads. Several pieces of evidence suggests that gamma-ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4afc117566b5724213689c31830e770a
https://doi.org/10.1159/000521649

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MON-222 Blocking GABAB Receptors (GABABR) from Birth to Weaning in Mice Induces Profound Changes in the Gonadotropic Axis

Autor: Carlos Libertun, Marianne Bizzozzero Hiriart, Noelia Paula Di Giorgio, Victoria Lux-Lantos

Publikováno v: Journal of the Endocrine Society

We have previously shown that the administration of a GABAB antagonist (CGP55845) to neonatal BALB/C mice from postnatal day (PND) 2-6 significantly decreased arcuate nucleus (ARC) kisspeptin (Kiss1) expression in both sexes. Furthermore, this neonat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3412472f94696ea7d5748c866a5828b
https://doi.org/10.1210/js.2019-mon-222

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Unraveling the connection between GABA and kisspeptin in the control of reproduction

Autor: Victoria Lux-Lantos, Noelia Paula Di Giorgio, Carlos Libertun, Marianne Bizzozzero-Hiriart

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Neuroendocrine control of reproduction involves the interplay of various factors that become active at some point along development. GnRH is the main neurohormone controlling reproduction and among the most important inputs modulating GnRH synthesis/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a90277e51d25e6418deb163064093b5
https://pubmed.ncbi.nlm.nih.gov/30844750

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Multiple failures in the lutenising hormone surge generating system in GABAB1KO female mice

Autor: Paula V López, Bernhard Bettler, Carlos Libertun, Pablo N Surkin, Marianne Bizzozzero Hiriart, Victoria Lux-Lantos, Verónica B Dorfman, Noelia Paula Di Giorgio, Nadia Bourguignon

Publikováno v: Journal of neuroendocrinologyREFERENCES. 31(8)

Female mice lacking GABAB receptors, GABAB1KO, show disrupted oestrous cycles, reduced pregnancies and increased hypothalamic Gnrh1 mRNA expression, whereas anteroventral periventricular/periventricular preoptic nucleus (AVPV/PeN) Kiss1 mRNA was not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f93ad53d40ddebc817d528c8d5e436e
https://pubmed.ncbi.nlm.nih.gov/31269532

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